Evaluating the effect of upper-body morbidity on quality of life following primary breast cancer treatment: a systematic review and meta-analysis

Macdonald, Eliza; Amorim, Nadia; Hagstrom, Amanda D.; Markovic, Katarina; Simar, David; Ward, Rachel; Clifford, Briana

doi:10.1007/s11764-023-01395-0

Cited by 5 publications

(1 citation statement)

References 119 publications

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“…Shoulder pain and dysfunction can greatly impact quality of life for cancer survivors, affecting their physical, psychological, and social well-being [2,114,115]. It is critical to consider multiple etiologies of shoulder impairment, many of which are secondary to cancer treatments, such as postbreast surgery pain syndrome, radiation fibrosis syndrome and inflammatory arthralgia from hormonal and immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Lee,

Stubblefield

2024

Curr Phys Med Rehabil Rep

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Purpose of Review Shoulder dysfunction widely affects function and quality of life of cancer survivors. This paper discusses the etiology, identification, evaluation, and management of the common shoulder impairments seen in cancer survivors, particularly those with breast cancer, head and neck cancer, and Hodgkin lymphoma. Recent Findings Shoulder dysfunction can be caused by a wide range of sources, often as a sequelae of cancer treatments including surgery, systemic therapy, and radiation therapy. These can change the shoulder biomechanics leading to musculoskeletal disorders such as rotator cuff disease and adhesive capsulitis. Other etiologies include neuromuscular complications, such as post-breast surgery pain syndrome and radiation fibrosis syndrome, and lymphovascular disorders such as lymphedema and axillary web syndrome. Metastatic bone disease and primary bone cancer should be considered for those with intense shoulder pain. Detailed history and physical exam, and in some cases, imaging can assist with evaluation of shoulder issues. Exercise, physical and occupation therapy are essential in managing shoulder dysfunction. Summary Shoulder dysfunction can limit function and quality of life for cancer survivors. It is important to consider the possible etiologies as accurate diagnosis is critical for optimal treatment.

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Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Lee,

Stubblefield

2024

Curr Phys Med Rehabil Rep

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Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2)

Aydin,

Gürsoy

2024

Support Care Cancer

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Exercise interventions for self-perceived body image, self-esteem and self-efficacy in women diagnosed with breast cancer: a systematic review with meta-analysis and meta-regressions

Casuso-Holgado,

Martinez-Calderon,

Martínez-Miranda

et al. 2024

Support Care Cancer

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Purpose To synthesise the effectiveness of exercise interventions on self-perceived body image, self-esteem and self-efficacy in women diagnosed with breast cancer who are undergoing or have completed primary adjuvant treatments. Methods A systematic review was conducted with meta-analysis and meta-regressions. Five electronic databases were searched from inception to June 2023, and hand searches were performed to explore the reference lists of similar systematic reviews. The established selection criteria were randomised clinical trials that evaluated any type of physical exercise intervention with self-perceived body image, self-esteem and self-efficacy as outcomes. No restrictions were imposed with respect to the control group. Main characteristics were extracted for each study. Meta-analyses, meta-regressions and sensitivity analyses were performed. The certainty of evidence for each outcome was graded using the GRADE approach. The risk of bias was evaluated using the RoB2 Cochrane tool. Results Twenty studies, comprising 19 different samples (n = 2030), were included. In general, meta-analysis indicated that physical exercise interventions were not superior to controls for improving self-esteem and body image in women diagnosed with breast cancer. However, subgroup meta-analysis showed a significant difference in self-esteem improvement for resistance exercise (SMD = 0.31; 95% CI = 0.07, 0.55; p = 0.01; I2 = 0%) and supervised exercise (SMD = 0.25; 95% CI = 0.08, 0.42; p = 0.0004; I2 = 0%) compared with controls. Self-efficacy results were scarce and controversial. In addition, serious concerns were mainly detected in terms of the risk of bias and indirectness of the evidence, which caused the certainty of evidence to be very low for all outcomes. Conclusion Supervised exercise and resistance training appear to be effective exercise modalities for improving self-esteem in women diagnosed with breast cancer. In contrast, exercise interventions are not significantly associated with improvements in body image, while results on self-efficacy are controversial. However, due to the study’s limitations, further research is needed.

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Evaluating the effect of upper-body morbidity on quality of life following primary breast cancer treatment: a systematic review and meta-analysis

Cited by 5 publications

References 119 publications

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2)

Exercise interventions for self-perceived body image, self-esteem and self-efficacy in women diagnosed with breast cancer: a systematic review with meta-analysis and meta-regressions

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