Evaluating the effectiveness of the new mouthguard design in athletes involved in power sports

Асташина, Н. Б.; Sergeeva, E. S.; I, G.; Lukanin, A. N.; Kazakov, S. V.

doi:10.17116/stomat201695640-43

Cited by 1 publication

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“…However, this view is gradually changing as we gain more insights about the role of B cells in host innate and adaptive immunity. An asynchronous relationship identified between the clinical periodontitis index and the antibody concentration in the diseased sites suggests that B cell functions may be pleiotropic in regulating periodontal inflammation [120]. Accumulated reports now suggest that in addition to T helper cells, certain subsets of B cells may be another source of immune regulators of the host immune response [121].…”

Section: Protective Effects Of Immune Regulatory B Cells In the Inflammation And Periodontal Bone Resorptionmentioning

confidence: 99%

Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease

Gu¹,

Han

2020

IJMS

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Periodontitis is known to be initiated by periodontal microbiota derived from biofilm formation. The microbial dysbiotic changes in the biofilm trigger the host immune and inflammatory responses that can be both beneficial for the protection of the host from infection, and detrimental to the host, causing tissue destruction. During this process, recognition of Pathogen-Associated Molecular Patterns (PAMPs) by the host Pattern Recognition Receptors (PRRs) such as Toll-like receptors (TLRs) play an essential role in the host–microbe interaction and the subsequent innate as well as adaptive responses. If persistent, the adverse interaction triggered by the host immune response to the microorganisms associated with periodontal biofilms is a direct cause of periodontal inflammation and bone loss. A large number of T and B lymphocytes are infiltrated in the diseased gingival tissues, which can secrete inflammatory mediators and activate the osteolytic pathways, promoting periodontal inflammation and bone resorption. On the other hand, there is evidence showing that immune regulatory T and B cells are present in the diseased tissue and can be induced for the enhancement of their anti-inflammatory effects. Changes and distribution of the T/B lymphocytes phenotype seem to be a key determinant of the periodontal disease outcome, as the functional activities of these cells not only shape up the overall immune response pattern, but may directly regulate the osteoimmunological balance. Therefore, interventional strategies targeting TLR signaling and immune regulatory T/B cells may be a promising approach to rebalance the immune response and alleviate bone loss in periodontal disease. In this review, we will examine the etiological role of TLR signaling and immune cell osteoclastogenic activity in the pathogenesis of periodontitis. More importantly, the protective effects of immune regulatory lymphocytes, particularly the activation and functional role of IL-10 expressing regulatory B cells, will be discussed.

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Section: Protective Effects Of Immune Regulatory B Cells In the Inflammation And Periodontal Bone Resorptionmentioning

confidence: 99%

Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease

Gu¹,

Han

2020

IJMS

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Evaluating the effectiveness of the new mouthguard design in athletes involved in power sports

Cited by 1 publication

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Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease

Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease

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