The Internet of Things is moving fast to be the Internet of Everything. This brings several challenges in several areas of Computing Systems, as in Embedded Systems, Computer Architectures, Fault Tolerance and Integrated Circuits and Systems. One common point is the power optimisation, as the demanding energy is increasing year by year. Optimisation must be done in all levels of design abstraction, system, computer architecture till the physical design. Another issue is reliability and fault tolerance as systems at ground level can be affected by radiations reaching the ground. Also, as several devices in IoT are related to sensitive applications, security is also an important issue in different design levels, including the physical one. The talk will present an overview of all these issues, proposing also some solutions.