Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

King, Shelby M.; Burdette, Joanna E.

doi:10.5483/bmbrep.2011.44.7.435

Cited by 25 publications

(25 citation statements)

References 90 publications

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“…In the hen, the expression of proteins that are specifically expressed in the oviduct during the later stages of the disease, such as ovoalbumin, ovostatin 2, PAX2 protein or EGFR1, indicate involvement of the oviduct in disease development (10,72). This finding supports the involvement of the Fallopian tube epithelium in spontaneous EOC, as in humans.…”

Section: Incessant Ovulation Hypothesissupporting

confidence: 75%

“…There is currently no consensus regarding the origin of EOC and it is considered to either derive from malignant alterations of the ovarian surface epithelium (17), or from the abnormal development of the Fallopian tube epithelium (18). The complexity of EOC appears to indicate that the ovarian surface epithelium as well as the Fallopian tube epithelium are involved in the development of this disease (10). The ovarian surface epithelium as the origin for EOC is the oldest hypothesis and has been associated with the high frequency of ovulation in women (19)(20)(21).…”

Section: Pathology and Origin Of Eoc In Humansmentioning

confidence: 99%

“…Different EOC types display remarkable diversity at the cellular and molecular levels (10,78). There is currently a scarcity of evidence regarding the role of specific genes in the development of EOC in humans, which appears to have heterogenic causes (78).…”

Section: Incessant Ovulation Hypothesismentioning

confidence: 99%

“…On the other hand, EOC was recently associated with abnormalities of the Fallopian tube epithelium. The Fallopian tube epithelium has been proposed as an origin of EOC, since several proteins normally expressed by the oviduct, such as paired box 8 (PAX8) and cancer antigen (CA)-125, have been found to be expressed in EOC biopsies (10,29). Moreover, it has been suggested that a genetic predisposition in Fallopian tube epithelial cells gives rise to EOC; this includes mutations in DNA damage repair genes, such as BRCA1 and BRCA2 and cell cycle regulators, such as P53 (30).…”

Section: Pathology and Origin Of Eoc In Humansmentioning

confidence: 99%

“…One of the greatest challenges in EOC research is to understand its cellular and molecular origin(s) (10). Different in vivo and in vitro systems have been used to model EOC.…”

Section: Introductionmentioning

confidence: 99%

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Advantages of the avian model for human ovarian cancer

Bernardo

Þorsteinsdóttir

Mummery

2015

Molecular and Clinical Oncology

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Abstract. Ovarian cancer (OC) is the most lethal gynecological cancer. Early detection of OC is crucial for providing efficient treatment, whereas high mortality rates correlate with late detection of OC, when the tumor has already metastasized to other organs. The most prevalent type of OC is epithelial OC (EOC). Models that have been used to study EOC include the fruit fly, mouse and laying hen, in addition to human EOC cells in 3D culture in vitro. These models have helped in the elucidation of the genetic component of this disease and the development of drug therapies. However, the histological origin of EOC and early markers of the disease remain largely unknown. In this study, we aimed to review the relative value of each of the different models in EOC and their contributions to understanding this disease. It was concluded that the spontaneous occurrence of EOC in the adult hen, the prolific ovulation, the similarity of metastatic progression with that in humans and the advantages of using the chicken embryo for modelling the development of the reproductive system, renders the hen particularly suitable for studying the early development of EOC. Further investigation of this avian model may contribute to a better understanding of EOC, improve clinical insight and ultimately contribute to decreasing its mortality rates among humans.

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Section: Incessant Ovulation Hypothesissupporting

confidence: 75%

Section: Pathology and Origin Of Eoc In Humansmentioning

confidence: 99%

Section: Incessant Ovulation Hypothesismentioning

confidence: 99%

Section: Pathology and Origin Of Eoc In Humansmentioning

confidence: 99%

“…One of the greatest challenges in EOC research is to understand its cellular and molecular origin(s) (10). Different in vivo and in vitro systems have been used to model EOC.…”

Section: Introductionmentioning

confidence: 99%

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Advantages of the avian model for human ovarian cancer

Bernardo

Þorsteinsdóttir

Mummery

2015

Molecular and Clinical Oncology

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Tumour Biomarkers in Gynaecologic Oncology

Kakoti¹,

Barmon²,

Kataki³

et al. 2022

Fundamentals in Gynaecologic Malignancy

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Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats

et al. 2013

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Cladribine has been used in the treatment of hairy cell leukemia for about 30 years. In addition, the number of indications for the application of 2-CdA is constantly increasing. The treatment with cladribine, of younger persons and even children, appears to be a major factor stimulating the more exact recognition of its activities. However, till now, little has been known about the impact of cladribine on the reproductive system. The aim of the study was to evaluate the immunohistochemical expression of cell proliferation and apoptosis markers in ovarian surface epithelial (OSE) cells. In our study, ten rats were placed into two equal groups. The study group received daily subcutaneous injections of cladribine in a dose of 0.10 mg/kg of weight/day for one cycle lasting 7 days. The control group received only saline injections. The rats were sacrificed 24 h after the last injection, and their ovaries were extracted. The sections were immunohistochemically stained with cell proliferation marker Ki-67 and the apoptosis marker caspase 3. The expressions of the markers were evaluated using a light microscope. An analysis was made using an image analysis system and the CellAD software. The results were then statistically explored by way of the Mann–Whitney U test. The proliferative index (Ki-67) of ovarian surface epithelial cells was significantly lower in the study group than in the control group (p < 0.05). These results suggest that cladribine treatment has a potential to inhibit the OSE cell proliferation in rats. The apoptosis marker demonstrated a significant increase after the cladribine treatment. These suggest that cladribine induces apoptosis in OSE cells.

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Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

Cited by 25 publications

References 90 publications

Advantages of the avian model for human ovarian cancer

Advantages of the avian model for human ovarian cancer

Tumour Biomarkers in Gynaecologic Oncology

Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats

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