2024
DOI: 10.36283/pjmd13-3/018
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Evaluating Vitamin E's Antioxidative Effect on Carbamazepine-Induced Spleen Damage in Rat Models

Asma Basharat Ali,
Nadia Younus,
Sahrish Mukhtar
et al.

Abstract: Background: The spleen is essential for the body’s homeostasis and immune system. Carbamazepine (CBZ) is known to cause toxicity to several organs, including the spleen, through oxidative stress, however, vitamin E (Vit E) is a proven antioxidant against toxins. Thus, this study evaluated the antioxidative effect of Vit E on hematological and splenic toxic changes, caused by carbamazepine in rats. Methods: This in-vivo preclinical experimental study was conducted from March-June 2020, at Jinnah Medical and Den… Show more

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