Evaluation and Comparative Study of Hypoglycaemic Activity of Morus Alba With Oral Hypoglycaemic Drug (Glibenclamide) in Alloxan Induced Diabetic Rats

Abstract

Diabetes mellitus is a metabolic disorder due to relative or absolute lack of insulin, resulting in elevated blood glucose levels in association with long-term vascular and neurological complications. Despite the availability of many antidiabetic medicines in the market, diabetes and its related complications continue to be major medical problems. The currently used hypoglycaemic drugs in the treatment of diabetes are not completely effective and are associated with adverse effects both in the short and long run. Some studies have reported many different medicinal properties of mulberry leaves (Morus alba) like neuroprotective property, cardioprotective property, anti-depressant property. It is used as an anti-inflammatory, diuretic, expectorant and antidiabetic in traditional Chinese medicine. So this study is undertaken to evaluate the hypoglycaemic effect of aqueous extract of leaves of Morus alba in Alloxan induced diabetic albino rats. OBJECTIVES To study the hypoglycaemic activity of Morus alba in Alloxan induced model of diabetes in albino rats. To compare the hypoglycaemic activity of Morus alba with that of standard drug Glibenclamide. METHODSTotal 24 albino rats of either sex weighing 150-200 gms were selected and randomly divided into 4 equal groups containing 6 rats in each group. First group (Non-diabetic control) was given normal saline (0.5 mL). Other 3 groups were induced diabetes by giving Alloxan (150 mg/kg ip). They were subdivided into diabetic control group receiving normal saline (0.5 mL), standard control group receiving Glibenclamide (0.5 mg/kg body weight) and test group receiving Morus alba extract (600 mg/kg). Fasting blood sugar level was estimated on day 0, 1, 3, 7, 14, 21 and 28 by using glucometer. Data were statistically analysed by Tukey's Post Hoc test and ANOVA. RESULTSMorus alba at the above doses significantly reduced blood glucose levels as compared to control group (p<0.01), but as compared to standard drugs (Glibenclamide) it is statistically insignificant (p>0.05). CONCLUSIONThe result suggests that Morus alba leaves have hypoglycaemic activity.

Morus Plant Genus: Superb Antidiabetic Activity and Outstanding Source of Nutrients

“…L Ext Aqueous: was orally supplemented (600 mg/kg BW, daily, 28 days) to rats resulted lowering of blood glucose [44] L Ext Ethanolic: extracts were prepared from female and male trees, from leaves and stems, and in different seasons. All extracts were tested for their α-amylase and α-glucosidase inhibition activity.…”