Evaluation and efficacy of carbon dioxide therapy (carboxytherapy) versus mesolipolysis in the treatment of cellulite

Eldsouky, Fatma; Ebrahim, Howyda Mohamed

doi:10.1080/14764172.2017.1400175

Cited by 16 publications

(28 citation statements)

References 17 publications

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“…The DCAGB course influenced patients' peripheral blood in all age groups like an antioxidant, significantly increasing erythrocyte peroxide resistance, which is largely associated with hypolypidemic carbon dioxide effect [15,14]. Subsequent to the DCAGB course exposure, most parameters reflecting the level of the LP processes showed significant oppression of the process, additionally elimination of the metabolic acidosis developed during the aging of the organism was observed, as well as increased alkaline reserve and improved peripheral blood oxygenation, which together contributed to the reduction of biological and cardiopulmonal age of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Literature contains information on the role of CO2 in organism metabolism and functions regulation of its systems, on the presence of antioxidant properties of CO2; several mechanisms of its influence on the lipid peroxidation processes in animals and humans are presented etc. [12,13,14,15]. At the same time, the role of CO2 in the regulation of aging and biological age change is not sufficiently covered in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Use of dry carbonic acid gas baths to correct human biological age

et al. 2020

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Relevance. The physiotherapy method of dry carbonic acid gas baths (DCAGB) mediated through the effects of carbon dioxide (CO2) is a minimally invasive treatment and prevention method of many human diseases. However, the CO2 effect on the rate of human aging has not been sufficiently studied. Therefore, it is relevant to study the effect of dry carbonic acid gas baths (DCAGB) physiotherapy method on peripheral blood indicators and biological age. Purpose. To assess the effect of carbon dioxide in dry carbonic acid gas baths condition on peripheral blood indicators and biological age in patients of different age groups. Patients and methods. An interventional single center controlled clinical trial was conducted on 140 male patients. Within 1 day before the DCAGB sessions course start (10 sessions 40 minutes each) and 1 day after course completion, patients’ peripheral blood samples were studied, as well as biological and cardiopulmonal age on the patented method was determined. Results. DCAGB course reduced biological age in young and middle-aged patients by 5.5 years (p<0.001), elderly and old patients – by 4.7 years (p<0.001), elderly and old patients had a decrease in cardiopulmonal bio age by 8.6 years (p<0.01). Conclusion. The course of DCAGB sessions slowed the aging rate of the human body from young to old age, which was probably associated with antihypoxic, antitoxic, antioxidant effects of carbon dioxide, as well as possibly with erythropoiesis activation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of dry carbonic acid gas baths to correct human biological age

et al. 2020

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“…14 Regarding wound healing resulting specifically from chronic venous insufficiency, it is known that the repair process occur slowly, and it is insufficient because the migration of cells is inefficient, which causes the chronicity of this condition as the region cannot be reepithelialised, 15 resulting in dysfunctional tissue in the affected area. 3 The literature on the improvement of this condition does not present concise and recent findings, so we consider the choice of the carboxytherapy in this study because the carbon dioxide used in this process is non-toxic, cost-effective, and safe 16,17 and I II III I II III I II III I II I II III I II III I II III I II respects the principle primum non nocerae (first of all not to prejudice), aiming to stimulate, or at least not inhibit, cell replication. 18 The present study confirmed the decrease of the inflammatory process after treatment with carboxytherapy, which promotes an increase of cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Brochado¹,

Schweich

Simões³

et al. 2018

International Wound Journal

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To examine the influence of carboxytherapy on wound healing under venous insufficiency, full‐thickness excisional wounds were created on Wistar rats. We used three groups with 32 rats each: Group (I): daily cleaning with 0.9% saline solution; Group Sulfadiazine (II): 1% silver sulfadiazine; and Carboxytherapy (III): subcutaneous application of 0.3 mL of carbon dioxide. The predetermined periods of analysis were the 3rd, 7th, 14th, and 30th day. The slides were stained with haematoxylin and eosin and Picrosirius red and submitted for immunohistochemistry. Groups II and III presented a statistically significant decrease in relation to the presence of neutrophilic and lymphocytic infiltrates. The presence of collagen significant increased in groups II and III. However, group III presented better organisation. Only group I maintained the neovascularisation until the 30th day. The new epithelium statistically significantly increased in groups II and III. On immunohistochemistry, regarding fibronectin expression, only group III demonstrated a statistically significant increase since the beginning of the healing process. Thus, the use of carboxytherapy promotes the formation of a tissue better structured and that may be an important resource for the treatment of wounds under venous insufficiency, especially those of recurrent re‐openings.

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“…A similar effect is achieved as a local treatment by a subcutaneous micro-injections administration of CO2 to multiple sites in the affected area (Brandi, 2010). This latter is also a subject to topical application in cosmetology for treatment of cellulite, stretch marks and in the rejuvenation of certain skin areas (Eldsouky et al, 2018). Specific and characteristic effects being observed during partial or full immersion of the human body in CO2-rich water or in dry-CO2 bath applications, which is similar to natural "mofetta gas-mix" effect that being used in some regions of Central Europe.…”

Section: Introductionmentioning

confidence: 95%

Methodological aspects of dose calculations in transdermal carbon dioxide therapy: estimation of absorbed dose and confirmation of systemic distribution

2021

DRCSF

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Carbon dioxide (CO2) gas is well characterized for medical applications. It is a chemically stable, biocompatible agent that has a long history of traditional use (in natural “mofettes”) particularly in Hungary, as a natural infallible remedy. Medical CO2 gas has been widely used in various area of medicine, mostly in surgical laparoscopy and endoscopic procedures in gastroenterology as an insufflation gas, since it is considered as an inert gas without side effects and the residuals easily absorbed in vascular tissues. On the other hand, the scope of intended use in case of transdermal or intradermal application is substantially different. Based on its primary mechanism of action carbon dioxide along with some other metabolites can cause prompt vasodilation of precapillary sphincters of blood vessels, and consequently a reduction of peripheral resistance and an increase the flow of microcirculation in tissues. Additionally, an increase in perivascular partial oxygen pressure in tissues (tcPO2) has been detected, because of a shift on the oxyhemoglobin dissociation curve, which resulted in an overall enhancement of oxygenation for cells. Scientific literature revealed some other aspects of physiology during transdermal CO2 gas administration, mainly in the field of microcirculation and tissue oxygenation. In this report we confirm the rate of absorption and the systemic elimination and highlight the principles of calculation for distribution and dosing utilizing the methodology of stable isotope ratio analysis. All these data may provide at least one further step supporting the use of carbon dioxide as an effective, non-invasive, convenient therapy. For the future this low-cost treatment option can be considered either (i) as a therapy with a reasonable cost-effectiveness ratio; or (ii) as an adjuvant therapy in rehabilitation with significant increase in quality of life for patients, alternatively (iii) as a prevention transdermal CO2 may provide a safe method for public access with a potential health benefit and reducing the symptoms of arterial and venous disease development.

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Evaluation and efficacy of carbon dioxide therapy (carboxytherapy) versus mesolipolysis in the treatment of cellulite

Abstract: Carboxytherapy and mesolipolysis are safe and effective in cellulite treatment. Carboxytherapy is a promising alternative therapeutic modality for cellulite treatment.

Cited by 16 publications

References 17 publications

Use of dry carbonic acid gas baths to correct human biological age

Use of dry carbonic acid gas baths to correct human biological age

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Methodological aspects of dose calculations in transdermal carbon dioxide therapy: estimation of absorbed dose and confirmation of systemic distribution

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