Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer

Salem, Heba F.; Kharshoum, Rasha M; El-Ela, Fatma I. Abo; Gamal, Amr; Abdellatif, Khaled R.A.

doi:10.1007/s13346-018-0499-3

Cited by 55 publications

(28 citation statements)

References 25 publications

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“…Additionally, it provides 3D graphs for assessing the impact of independent variables on Y 1 -Y 4 . After analysis of all quantative outcomes of Y 1 -Y 4 , the point prediction method was used to select the optimum formulation [21].…”

Section: Optimization Of Rldl Formulationsmentioning

confidence: 99%

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

et al. 2021

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Breast cancer is the most frequent malignancy in women. This work focuses on developing deformable liposomes as a potential carrier for breast cancer treatment and studying the impact of improving dermal permeation on the efficacy and targeting of liposomes. Raloxifene (RXF), an oestrogen antagonist, was used as a model drug. Using Box–Behnken design, different formulations of RXF-loaded deformable liposome (RLDL) were prepared using different propylene glycol, phospholipid and cholesterol concentrations. The percentage of entrapment efficiency (Y1), particle size (Y2), zeta potential (Y3) and steady-state flux (Y4) of the prepared formulations were all evaluated. Y1 and Y4 were significantly increased and Y2 and Y3 were significantly decreased when the propylene glycol concentration was increased. The optimization was obtained and the optimum formulation was that including phospholipid (1.40% w/w), cholesterol (0.15% w/w) and propylene glycol (10% v/v). The selected optimum formulation displayed a % EE of 78.34 ± 1.04% with a steady-state flux of 4.21 ± 0.02 µg/cm2/h. In order to investigate bioavailability, antitumor effectiveness and permeation, the optimum formulation was selected and included in a carbopol gel. The optimum gel formulation had 2.77 times higher bioavailability and, as a result, considerable antitumor action as compared to oral RXF. In conclusion, optimum RLDL gel may be an effective breast cancer treatment.

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Section: Optimization Of Rldl Formulationsmentioning

confidence: 99%

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

et al. 2021

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“…All experiments were carried out in triplicate and sample size was calculated by taking average of the three runs. 15 , 16 The samples were analyzed using one-way ANOVA statistical test. The data were normally distributed, and the distribution was tested with Kolmogorov–Smirnov test.…”

Section: Methodsmentioning

confidence: 99%

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Abou-Taleb¹,

Khallaf²,

Abdel-Aleem³

2018

DDDT

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ObjectiveOne of the greatest challenges drug formulation is facing is poor bioavailability via oral route. In this regard, nasal drug delivery has been commonly used as an alternative route to improve drug bioavailability. Nefopam hydrochloride (NF) is an analgesic drug that suffers from poor bioavailability due to extensive metabolism in liver. Accordingly, the goal of the present study was to improve NF bioavailability via niosomal-based formulation designed for intranasal delivery.Materials and methodsVesicles were developed by mixing surfactants (Span 20, Span 40, Span 80, and Span 85) at four molar ratios of 1:1, 1:2, 1:3, and 1:4 of cholesterol to surfactant. Entrapment efficiency, particle size, zeta potential, release percentage, ex-vivo permeation parameters, and niosomes’ stability were determined. Also, the pharmacokinetic parameters of the optimized formula in in-situ gel base were measured in rats.ResultsNiosomes showed entrapment efficiency .80%, particle size ,550 nm, and zeta potential ranging from -16.8±0.13 to -29.7±0.15. The produced vesicles showed significantly higher amounts of drug permeated across nasal mucosa (2.5 folds) and prolonged NF release compared with NF solution. Stability studies of optimum formula showed nonsignificant changes in niosomes parameters over a storage period of 6 months. The in-vivo studies showed a 4.77-fold increase in bioavailability of optimized nasal niosomes compared with oral solution of drug.ConclusionThe obtained results revealed the great ability of the produced NF-loaded nio-somes to enhance drug penetration through nasal mucosa and improve its relative bioavailability compared with NF oral solution.

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“…On the other hand, niosomes have become one of the most interesting LBNPs in BreC treatment, which has led to the development of various systems to facilitate the vehiculization of gingerol [106], tamoxifen citrate (TXC) [107,108], carboplatin [109], silibinin [110,111], lawsone [112], mitoxantrone [113] or TQ [114]. Accordingly, Shaker et al [108] synthesized a TXC-niosome capable of increasing drug uptake in MCF-7 cells and reducing tumor volume in Ehrlich carcinoma model in vivo.…”

Section: Application Of Lipid-based Nanoparticles In Cancer Therapymentioning

confidence: 99%

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

et al. 2019

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Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue. LBNPs have been extensively assayed in in vitro cancer therapy but also in vivo, with promising results in some clinical trials. This review summarizes the types of LBNPs that have been developed in recent years and the main results when applied in cancer treatment, including essential assays in patients.

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Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer

Cited by 55 publications

References 25 publications

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

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