Evaluation by digital subtraction radiography of induced changes in the bone density of the female rat mandible

Mahl, Célia Regina Winck; Fontanella, Vania Regina Camargo

doi:10.1259/dmfr/58263510

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…They can be used not only as a tool for assessing cases of fractures, but also to evaluate procedures that involve bone repair and regeneration 14 , meeting the objective proposed in the present study. The acquisition of digital radiographs with animals secured on a radiographic platform, as described in the methods, enabled us to obtain standardized, good quality radiographs 15 .…”

Section: Analysis Of Optical Density Within Groupsmentioning

confidence: 99%

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

et al. 2011

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Purpose: To evaluate new bone formation, by the analysis of optical density, in rat femoral defects filled with calcium phosphate cement (CPC) and bioactive glass (BG). Methods: Twenty-one rats were divided into three groups, Group I (CPC), Group II (BG), and Group III (control), and assessed after 7, 15, and 30 days. Three bone cavities were made in the left femur and filled with CPC, BG, and no material (control). Digital images were obtained and the results were subjected to statistical analysis of variance (ANOVA), complemented by the Friedman and Kruskal-Wallis nonparametric tests, with a significance level of 5%. Results: Regarding optical density, Group I showed statistical values significantly higher than Group III and also higher, although not statistically significant, than Group II, in all observation periods. When Groups II and III were compared, Group II showed higher optical density values, without statistically significant differences, in all periods. Conclusion: The biomaterials analyzed showed higher optical density in relation to the control group in all observation periods, calcium phosphate cement being the best option in the repair of bone defects, but without statistically significant differences in relation to bioactive glass.

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Section: Analysis Of Optical Density Within Groupsmentioning

confidence: 99%

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

et al. 2011

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“…No presente estudo a região da crista óssea foi mais atingida devido ao maior teor de tecido ósseo esponjoso, o qual, geralmente, apresenta taxa metabólica maior, respondendo mais rapidamente às mudanças mecânicas do que o osso cortical (Downey & Siegel, 2006). Na análise histomorfométrica notou-se diminuição significativa do POA da mandíbula e do POT do fêmur nos animais tratados com glicocorticóide, evidenciando a redução óssea alveolar mandibular e femural encontrada por outros autores (Fujita et al, 2008;Mahl & Fontanella, 2008;Pinto et al, 2006;Natsui et al, 2006).…”

Section: Resultsunclassified

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Lucinda¹,

Vieira²,

Salvador³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Este trabalho investigou os efeitos do tratamento por vinte dias com extrato de Ginkgo biloba (EGb) na osteoporose induzida por glicocorticóides. Foram utilizadas 36 ratas divididas em seis grupos (n=6): Controle, osteoporose, controle positivo, EGb1 (14 mg EGb/mg/kg/dia), EGb2 (28 mg EGb/kg/dia) e EGb3 (56 mg EGb/kg/dia). Os tratamentos foram realizados por vinte dias, após a indução da osteoporose. Após a eutanásia foram removidos o fêmur e a mandíbula de todos os animais. A mandíbula esquerda foi radiografada digitalmente para avaliação da cortical e do suporte ósseo periodontal (SOP). A análise histomorfométrica foi realizada no fêmur e mandíbula direitos. O grupo controle foi comparado ao grupo osteoporose (Teste t de Student) e os demais grupos foram submetidos a ANOVA, seguido do teste post-hoc de Dunnett. Houve redução significava do SOP mesial, percentual ósseo alveolar (POA) mandibular, percentual ósseo trabecular (POT) do fêmur no grupo osteoporose. Houve aumento do SOP mesial no grupo controle positivo, EGb2 e EGb3. O POA da mandíbula e o POT do fêmur aumentaram nos grupos EGb2 e EGb3. O EGb nas doses de 28 mg/kg e 56 mg/kg recuperou de forma significativa o SOP mesial, o POA da mandíbula e o POT do fêmur. Unitermos:Ginkgo biloba, osteoporose, radiografia, histomorfometria, alendronato de sódio, ratos.ABSTRACT: "Effect of the aqueous extract of Ginkgo biloba L., Ginkgoaceae, in induced osteoporosis in Wistar rats." The objective of this study was to investigate the effect of a 20 day treatment with extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. 36 rats were divided into six groups (n=6): control, osteoporosis, positive control, EGb1 (14 mg EGb/kg/day), EGb2 (28 mg EGb/kg/day) and EGb3 (56 mg EGb/kg/day). Treatments were conducted for twenty days, after osteoporosis was induced. Following euthanasia the femur and mandible of all animals were removed. The left mandible was radiographed to evaluate the cortical and the periodontal bone support (PBS). The histomorphometric analysis was performed on the right mandible and the right femur. The control group was compared with the osteoporosis group (Student's t-test). The other groups were analyzed through ANOVA test followed by Dunnett post-hoc test. There was a significantly reduction in the mesial PBS, in the percentage of the alveolar bone (PAB) of the mandible and percentage of the trabecular bone (PTB) of the femur in the osteoporosis group. There was an increase in the mesial PBS in the positive control group, EGb2 and EGb3. The PAB of the mandible and the PTB of the femur increased in the EGb2 and EGb3 groups. The EGb in the 28 mg/kg and 56 mg/kg doses were effective to increase the mesial PBS, the PAB of the mandible and the PTB of the femur.Keywords: Ginkgo biloba, osteoporosis, radiography, histomorphometric, sodium alendronate, rats. INTRODUÇÃOA osteoporose é caracterizada por uma redução na quantidade de tecido ósseo por unidade de volume (Hallworth, 1998) e por uma deteriorização da microarquitetura deste tecido...

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“…Furthermore, this is the first study describing both 2D and 3D parameters in parallel at the tibia and at the mandible. Rat is the most frequently animal model used to study the effects of GCs at the mandible and different measurement tools have been described, (microCT, pQCT, histomorphometry 2D) [19][20][21][22][23][24][25]. Reduction in mandibular cortical thickness has been reported [19] and an altered volume of alveolar bone has also been shown [21].…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoids reduce alveolar and trabecular bone in mice

Bouvard¹,

Gallois²,

Legrand³

et al. 2013

Joint Bone Spine

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Evaluation by digital subtraction radiography of induced changes in the bone density of the female rat mandible

Cited by 7 publications

References 41 publications

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Glucocorticoids reduce alveolar and trabecular bone in mice

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