Évaluation de la prévalence de l’hémosidérose post-transfusionnelle, étude SFVTT-01 : résultats préliminaires du groupe de travail de la SFVTT

Leo-Kodeli, S.; Renaudier, P.; Lassale, B.

doi:10.1016/j.tracli.2014.08.002

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Leisch et al 23 "Despite the unclear prognostic role of RBC alloantibodies in (…) MDS (…) patients, alloantibody formation remains a clinical problem in the management of these patients" Leo-Kodeli et al 24 "[The prevalence of hemosiderosis, especially its severe forms, is therefore high.]" Lin et al 25 "Such a [prophylactic Rh and Kell antigen-matched RBC transfusion] policy should be considered in transfusion-dependent patients with MDS, although further studies on cost-effectiveness and careful consideration of resource availability in the local context are required."…”

Section: Survivalmentioning

confidence: 99%

“…Nine studies reported outcomes relating to iron overload and its complications. 10,12,19,24,27,30,32,37,43 Three studies found an increased risk of iron overload complications among transfused MDS patients, including presentations of cardiomyopathy/heart failure, conduction disorders, diabetes and liver disease. 10,27,30 Two studies examined magnetic resonance imaging evidence of iron deposition with conflicting results about the correlation between liver iron and transfusion burden.…”

Section: Clinical Complicationsmentioning

confidence: 99%

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Red blood cell transfusion in myelodysplastic syndromes: A systematic review

Kaka

Jahangirnia

Beauregard

et al. 2021

Transfusion Medicine

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Patients with myelodysplastic syndrome (MDS) frequently receive red blood cell (RBC) transfusions for anaemia resulting from ineffective erythropoiesis. While RBC transfusions may rapidly increase haemoglobin values, their impact on clinical and health services outcomes in MDS patients has not previously been summarized. We conducted a systematic review of the literature to evaluate risks and benefits of RBC transfusions in MDS patients. We searched electronic databases (MEDLINE, Embase, CENTRAL, CINAHL) from inception through June 4, 2021 to identify studies reporting data on RBC transfusions in MDS patients. Full text publications that assessed RBC transfusions as an intervention and reported at least one clinical, laboratory, or healthcare outcome associated with transfusion were included. Study characteristics, transfusion information and transfusion-related outcomes were extracted and reported. We identified 1243 original studies, of which 38 met eligibility requirements and were included.Fourteen reported on survival following diagnosis of MDS, with the majority reporting poorer survival among patients receiving or requiring more frequent transfusions. Nine reported on transfusion-related iron overload and its complications. Other outcomes included rates of allo/autoimmunization and adverse transfusion reactions, and healthcare costs incurred by patients with a greater transfusion burden. Only two studies reported on symptom relief following transfusion. This review underscores transfusion dependence as a negative prognostic factor for MDS patients and highlights the paucity of evidence surrounding quality of life and symptom-related outcomes following RBC transfusions in this population. Further study of patient-important outcomes associated with transfusion in MDS patients is warranted to improve therapeutic recommendations and inform resource allocation.

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Section: Survivalmentioning

confidence: 99%