Évaluation de la teneur en gédunine dans différents organes d'Azadirachta indica A. Juss

Koumaglo, K.; Akogo, Yezoumi; Dotse, Kokouvi; Gbéassor, Messanvi; Arnason, John T.

doi:10.1016/j.crci.2003.12.032

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Gedunin is abundant in the fruit epicarp of Azadirachta indica A. Juss. and has higher concentrations in young green fruits than in ripe fruits [8]. A. indica leaves presented gedunin concentrations lower than 0.1% and a residual presence elsewhere in the plant.…”

Section: Introductionmentioning

confidence: 87%

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

et al. 2020

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Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.

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Section: Introductionmentioning

confidence: 87%

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

et al. 2020

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“…Gedunin is abundant in Azadirachta indica A. Juss. fruit epicarps, with a higher proportion in young green fruits than ripe fruits 6,31 . Gedunin concentration in A. indica leaves is less than 0.1 percent, with a residual presence in the rest of the plant 6,31 .…”

mentioning

confidence: 99%

“…fruit epicarps, with a higher proportion in young green fruits than ripe fruits 6,31 . Gedunin concentration in A. indica leaves is less than 0.1 percent, with a residual presence in the rest of the plant 6,31 . Antibacterial, antifungal, antiallergic, anti-inflammatory, antimalarial, anticancer, insecticidal, and neuroprotective properties have all been attributed to gedunin 6,32 .…”

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confidence: 99%

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2022

IJPSR

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Middle-East Respiratory Syndrome coronavirus (MERS-CoV) can trigger severe acute pneumonia, renal, digestive failure and even death. Coronaviruses express papain-like proteases (PLpro), multipurpose enzymes which had protease activity and can lacerate nonstructural proteins to manipulate the viral polyprotein responsible for replication. They also have deubiquitinating function, which can modify the innate immune response. The reduction of the infection of MERS-CoV is by Inhibition of PLpro with a ligand will wedge the cleavage progression of nonstructural protein. As a result, papain-like protease may be considered as a candidate for antiviral drug production. This current study focuses on screening of extracts from Neem and Eucalyptus for MERS-CoV that could be potentially used as an inhibitor against the disease. Blind molecular docking study was conducted by using Auto Dock followed by visualization using PyMol, which is examined in this existing study. Deacetylgedunin (Neem) and eucalyptol (Eucalyptus) showed successful binding to MERS-CoV papainlike protease based on measured parameters such as root Mean Square Deviation (RMSD), binding capacity and inhibiting constant. The compound Deacetylgedunin found in neem exhibited the lowest RMSD value of 16.388 Å and the highest binding energy of -8.28 kcal/mol. It also had the highest inhibition constant value of 851.36 nM and the lowest inhibition constant value of 851.36 nM. Since Deacetylgedunin gave a better result compared to Indinavir, hence it can be considered as a potential and safe alternative for the current medicine given for MERS-CoV disease. INTRODUCTION:Coronaviruses are massively (2632 kb in size) wrapped single-stranded ribonucleic acid (RNA) viruses that can infect many mammals 5 . They belong to the Coronaviridae family, and sub-categorised as Coronavirinae. "

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The Applied Validated Ultraviolet-Visible Spectrophotometric Method and the Kinetic Model of the Release of Gedunin from a Chitosan-Coated Liposome

Sahu

Jain

2016

J Appl Spectrosc

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Évaluation de la teneur en gédunine dans différents organes d'Azadirachta indica A. Juss

Cited by 5 publications

References 5 publications

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

Untitled

The Applied Validated Ultraviolet-Visible Spectrophotometric Method and the Kinetic Model of the Release of Gedunin from a Chitosan-Coated Liposome

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