Evaluation der Versorgungssituation von Sehbehinderten

Oeverhaus, Michael; Hirche, H.; Esser, Joachim; Eckstein, A.; Schaperdoth-Gerlings, B.

doi:10.1007/s00347-017-0643-3

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Further rehabilitative surgical interventions (e.g. squint and eyelid surgery) should follow after decompression surgery, since globe position, rotation, alignment and relative relationship to periocular soft tissue structures might be altered [18, 23, 24]. Depending on the desired effect, the lateral, medial and inferior wall can be resected, which enables expansion of the soft tissue and thereby reduction of orbital compression [18].…”

Section: Introductionmentioning

confidence: 99%

Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves’ orbitopathy

et al. 2019

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Purpose Orbital decompression surgery is performed in patients with Graves’ orbitopathy to treat dysthyroid optical neuropathy (DON) and reduce disfiguring proptosis. The intended proptosis reduction can deviate from the postoperative result and changes of motility with consecutive diplopia can occur. We performed a retrospective study to identify anatomical factors in computed tomography (CT), which influence the surgical effect and postoperative ocular motility and diplopia. Methods Pre- and postoperative CT-scans of 125 eyes of 68 patients, who mainly underwent a balanced orbital decompression for disfiguring proptosis (≥18mm Hertel Index), have been analyzed. Proptosis, ductions, misalignment and diplopia were assessed before and after surgery. Medial and lateral orbital wall length, conus angle, depth of ethmoidal sinus, orbital surface, length of medial and orbital defect, depth of tissue prolapse and horizontal muscle diameters were analyzed in CT scans before and after surgery. With linear regression and multivariate analyses these parameters have been correlated with postoperative proptosis, abduction deficit, deviation and binocular single vision (BSV). Results Proptosis could be reduced by 5.3±2mm. Patients with <5mm proptosis reduction had significantly less often new onset of diplopia compared to patients with >5mm reduction (13% vs. 56%, p = 0.02). Multiple linear regression showed a significant correlation between tissue prolapse and depth of the ethmoidal sinus as well as age (p<0.001, r = 0.71). Proptosis reduction could not be predicted by tissue prolapse, defect length or depth of ethmoidal sinus. The abduction deficit correlated significantly with tissue prolapse and orbital surface area (p<0.001, r = 0.37) but not with the horizontal muscle diameter. Conclusion We were able to show that orbital morphology influences the outcome of balanced orbital decompression surgery in terms of proptosis reduction and motility. However, the rather low coefficients of correlation show that the surgical outcome cannot be predicted with simple CT measurements, although risk factors for postoperative abduction deficit could be found. Therefore, preoperative planning should consider especially the orbital surface area and depth of ethmoidal sinus. Patients should be informed about the higher risk of diplopia with higher proptosis reduction.

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Section: Introductionmentioning

confidence: 99%

Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves’ orbitopathy

et al. 2019

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“…Depending on aging, the severity and the occurrence of AMD might increase, and although there are several treatment methods, such as device-based therapy, anti-inflammatory drug therapy, and anti-VEGF treatment, because AMD is an incurable disease, the best treatment is to prevent its occurrence. The current incidence rate of AMD in young and juvenile people has been rapidly increasing as the usage time of smart devices increases [101]; in order to reduce morbidity, smart devices' usage time should be reduced [102].…”

Section: Discussionmentioning

confidence: 99%

The Age-Related Macular Degeneration (AMD)-Preventing Mechanism of Natural Products

et al. 2022

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Age-related macular degeneration (AMD) is related to central visual loss in elderly people and, based on the increment in the percentage of the aging population, the number of people suffering from AMD could increase. AMD is initiated by retinal pigment epithelium (RPE) cell death, finally leading to neovascularization in the macula lutea. AMD is an uncurable disease, but the symptom can be suppressed. The current therapy of AMD can be classified into four types: device-based treatment, anti-inflammatory drug treatment, anti-vascular endothelial growth factor treatment, and natural product treatment. All these therapies have adverse effects, however early AMD therapy used with products has several advantages, as it can prevent RPE cell apoptosis in safe doses. Cell death (apoptosis) is caused by various factors, such as oxidative stress, inflammation, carbonyl stress, and a deficiency in essential components for cells, and RPE cell death is related to oxidative stress, inflammation, and carbonyl stress. Some natural products have anti-oxidative effects, anti-inflammation effects, and/or anti-carbonylation effects. The AMD preventive mechanism of natural products varies, with some natural products activating one or more anti-apoptotic pathways, such as the Nrf2/HO-1 anti-oxidative pathway, the anti-inflammasome pathway, and the anti-carbonyl pathway. As AMD drug candidates from natural products effectively inhibit RPE cell death, they have the potential to be developed as drugs for preventing early (dry) AMD.

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“…Факторами риска развития депрессивных симптомов были: одиночество, бедность, макулодистрофия, проблемы с адаптацией к потере зрения, снижение качества жизни, связанное со здоровьем, и переживание симптомов тревоги, а для более молодых -сложности на работе, связанные с ухудшением зрения. Показано, что частота депрессии и тревоги у пожилых людей с нарушениями зрения в 2 раза выше, чем у пожилых людей в целом [20,21]. Поэтому важно наблюдать за пожилыми людьми с нарушениями зрения и предлагать ранние вмешательства для профилактики и восстановления их психического здоровья.…”

Section: Modern Multicenter Studies Of Psychological Features Proper unclassified

The psychology of a glaucoma patient

Габдрахманов¹,

Газизова

Селезнев³

et al. 2020

Rossijskij oftalʹmologičeskij žurnal

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Современные многоцентровые исследования психологических особенностей пациентов с глаукомой свидетельствуют о наличии физиологических и психологических проблем, связанных с этим заболеванием. Высокий уровень тревоги обуславливает клинически значимое повышение внутриглазного давления. Частота депрессии и тревоги у пожилых людей с нарушениями зрения в два раза выше, чем у пожилых людей в целом. Дефицит поля зрения оказывает более неблагоприятное влияние на качество жизни пациентов с глаукомой, чем даже ухудшение остроты зрения, особенно при локализации дефекта поля зрения в нижней полусфере. Несоблюдение назначенного гипотензивного режима может быть вызвано неверием пациентов в благополучный исход заболевания, низким уровнем доверия к врачу, низким уровнем образования и низким ежемесячным доходом пациента, наличием побочных эффектов местной гипотензивной терапии, типом применяемых препаратов и их количеством. Ключевые слова: первичная открытоугольная глаукома; депрессия; тревога; качество жизни Конфликт интересов: отсутствует. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах.

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Evaluation der Versorgungssituation von Sehbehinderten

Cited by 7 publications

References 26 publications

Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves’ orbitopathy

Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves’ orbitopathy

The Age-Related Macular Degeneration (AMD)-Preventing Mechanism of Natural Products

The psychology of a glaucoma patient

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