Évaluation in vitro et in vivo d’une chambre d’inhalation fabriquée en Tunisie

Aloulou, I.; Bousoffara, R.; Khalifa, M.; Saad, Helmi Ben; Dessanges, J.F.; Tabka, Z.; Zbidi, A.

doi:10.1016/s0335-7457(01)00069-7

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2012

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“…Only less than 30% of the drug can reach the lungs (Wildhaber et al 1996;O'Callaghan 1999a, 1999b;Aloulou et al 2001). Along with the increased cost, the drug deposition can produce undesirable side effects.…”

Section: Introductionmentioning

confidence: 99%

Development of new spacer device geometry: a CFD study (Part I)

Oliveira

Teixeira

Silva

et al. 2012

Computer Methods in Biomechanics and Biomedical Engineering

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Asthma is a widespread disease, affecting more than 300 million individuals. The treatment in children is based upon an administration of a pressurised metered-dose inhaler added with a spacer. The efficiency of drug delivery to the patient is strongly affected by the transient airflow pattern inside the spacer device. This paper presents a computational fluid dynamics (CFD) analysis of airflow inside a commercially available spacer device with wide application. This study, carried out in Fluent™, was the basis of an optimisation procedure developed to improve the geometry of the spacer and develop a more efficient product. The results show that an appropriate control of the boundary layer development, by changing the spacer shape, reduces the length of the recirculation zones and improves the flow. It can be concluded that CFD is a powerful technique that can be successfully applied to optimise the geometry of such medical devices.

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Section: Introductionmentioning

confidence: 99%