Evaluation of a bladder tumor antigen test as a screening test for transitional cell carcinoma of the lower urinary tract in dogs

Abstract

Our results indicate that the V-BTA test is useful in screening for urinary tract TCC in dogs.

Ultrassonografia abdominal pré-operatória em cães e gatos com suspeita de tumores abdominais

“…Provavelmente, esses animais ainda estavam em fase inicial da doença, o que não permitiu a visibilidade dos achados ultrassonográficos já descritos na literatura. Dentre as neoplasias da bexiga, o carcinoma de células transicionais é o tipo histológico tumoral mais comum em cães (HENRY et al, 2003). As características das lesões tumorais já foram bem descritas na literatura (LEVEILLE, 1998) e o aspecto de massa vegetante é de fácil identificação, assim como foi visibilizado no cão 2 deste estudo.…”

Urinary Tract

“…This test is suitable to screen for TCC in dogs in the absence of moderate to marked hematuria, pyuria, glucosuria, or proteinuria (Borjesson et al, 1999). However, the specificity of the test declines rapidly if dogs have non-TCC urinary tract disease (Borjesson et al, 1999;Henry et al, 2003). Finally, cyclooxygenase-2 (COX-2), uroplakin III, and cytokeratin 7 show promise as useful immunohistochemical stains to verify tumors of urothelial origin in histology sections if needed (Khan et al, 2000;Knottenbelt et al, 2006;Ramos-Vara et al, 2003).…”

RADIATION THERAPY OF A PRESUMPTIVE URETHRAL TRANSITIONAL CELL CARCINOMA IN AN EASTERN GRAY SQUIRREL (SCIURUS CAROLINENSIS)

“…Additional suspicion was based on the V-BTA test, a rapid latex agglutination test developed to detect bladder tumor analytes in canine urine and intended for use as a noninvasive screening test in dogs with suspected TCC. 3,9 The sensitivity is high in dogs; however, the specificity is greatly reduced in the presence of nonneoplastic signs of lower urinary tract disease (e.g. pyuria, hematuria, glucosuria, proteinuria), which therefore does not make this test useful in the differentiation of bladder cancer from other types of urinary tract disease.…”