Evaluation of a high resolution silicon PET insert module

Grkovski, Milan; Brzezinski, Karol; Cindro, V.; Clinthorne, N.H.; Kagan, H.; Lacasta, C.; Mikuž, M.; Solaz, C.; Studen, Andrej; Weilhammer, P.; Žontar, D.

doi:10.1016/j.nima.2015.03.078

Cited by 12 publications

(18 citation statements)

References 28 publications

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“…The image grid of 0.2 × 0.2 × 0.2 mm 3 voxels was used in order to resolve the finest phantom features, which were within the expected resolution capabilities of the highest resolution data (Si-Si events) [6]. The resulting increase in image pixel density, by a factor of 125 from the 1 × 1 × 1 mm 3 image grid used in previous simulation studies [9], would indicate that an increase in the number of Siddon lines per detector pair is required.…”

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the data acquisition system and coincidence logic may be found in Grkovski et al [6]. …”

Section: Methodsmentioning

confidence: 99%

“…Several groups have explored such an approach using both ring-insert geometries [4–6], where the high-resolution detectors form a ring (or partial ring) within the conventional PET ring, and probe geometries [7, 8], where a single detector module is placed at a specific location. In such geometries, the fine segmentation of the insert detector does not reduce the statistical quality of the data; rather, counts are added as sensitivity is increased by the presence of the extra detector.…”

Section: Introductionmentioning

confidence: 99%

“…The setup has been used in previous works for examining several Si PET-insert geometries, focusing on the ring-insert and partial-ring configurations [4, 6]. While Grkovski et al [6] presented images obtained using the Si detector module at several angular positions (partial ring geometry), the current study examines an arrangement where the module is fixed at one position, thus mimicking the PET probe system presented in our previous simulation studies [9]. Furthermore, choosing a shorter acquisition time than Grkovski et al [6], in order to obtain data of similar statistical quality as that used in simulation [9], allows for a closer validation of the original simulated system.…”

Section: Introductionmentioning

confidence: 99%

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Experimental evaluation of the resolution improvement provided by a silicon PET probe

et al. 2016

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A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously shown that the additional probe information improves the spatial resolution of the reconstructed image and increases lesion detectability, with no cost to other image quality measures. The current study expands on the previous work by using a laboratory prototype of the silicon PET-probe system to examine the resolution improvement in an experimental setting. Two different versions of the probe prototype were assessed, both consisting of a back-to-back pair of 1-mm thick silicon pad detectors, one arranged in 32 × 16 arrays of 1.4 mm × 1.4 mm pixels and the other in 40 × 26 arrays of 1.0 mm × 1.0 mm pixels. Each detector was read out by a set of VATAGP7 ASICs and a custom-designed data acquisition board which allowed trigger and data interfacing with the PET scanner, itself consisting of BGO block detectors segmented into 8 × 6 arrays of 6 mm × 12 mm × 30 mm crystals. Limited-angle probe data was acquired from a group of Na-22 point-like sources in order to observe the maximum resolution achievable using the probe system. Data from a Derenzo-like resolution phantom was acquired, then scaled to obtain similar statistical quality as that of previous simulation studies. In this case, images were reconstructed using measurements of the PET ring alone and with the inclusion of the probe data. Images of the Na-22 source demonstrated a resolution of 1.5 mm FWHM in the probe data, the PET ring resolution being approximately 6 mm. Profiles taken through the image of the Derenzo-like phantom showed a clear increase in spatial resolution. Improvements in peak-to-valley ratios of 50% and 38%, in the 4.8 mm and 4.0 mm phantom features respectively, were observed, while previously unresolvable 3.2 mm features were brought 1

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Section: Discussionmentioning

confidence: 99%

“…A detailed description of the data acquisition system and coincidence logic may be found in Grkovski et al [6]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Experimental evaluation of the resolution improvement provided by a silicon PET probe

et al. 2016

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“…For example, scanner designs with a fixed number of detectors that allow a certain degree of mobility such as [365,371] are useful for certain medical applications [372]. Similarly, insert [373] or camera modules [372] cannot be added to a given scanner setup using a fixed frame and cabling is required instead. The same is often the case for the connection between subsystems in a dual modality scanner [374].…”

Section: Proposed Architecturementioning

confidence: 99%

Development of a data acquisition architecture with distributed synchronization for a Positron Emission Tomography system with integrated front-end.

Varea¹,

Ramón²

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Positron Emission Tomography (PET) is a non-invasive nuclear medical imaging modality that makes it possible to observe the distribution of metabolic substances within a patient's body after marking them with radioactive isotopes and arranging an annular scanner around him in order to detect their decays. The main applications of this technique are the detection and tracing of tumors in cancer patients and metabolic studies with small animals.The Electronic Design for Nuclear Applications (EDNA) research group within the Instituto de Instrumentación para Imagen Molecular (I3M) has been involved in the study of high performance PET systems and maintains a small experimental setup with two detector modules. This thesis is framed within the necessity of developing a new data acquisition system (DAQ) for the aforementioned setup that corrects the drawbacks of the existing one. The main objective is to define a DAQ architecture that is completely scalable, modular, and guarantees the mobility and the possibility of reusing its components, so that it admits any extension of modification of the setup and it is possible to export it directly to the configurations used by other groups or experiments. At the same time, this architecture should be compatible with the best possible resolutions attainable at the present instead of imposing artificial limits on system performance. In particular, the new DAQ system should outperform the previous one.As a first step, a general study of DAQ architectures is carried out in the context of experimental setups for PET and other high energy physics applications. On one hand, the conclusion is reached that the desired specifications require early digitization of detector signals, exclusively digital communication between modules, and the absence of a centralized trigger. On the other hand, the necessity of a very precise distributed synchronization scheme between modules becomes apparent, with errors in the order of 100 ps, and operating directly over the data links. A study of the existing methods reveals their severe limitations in terms of achievable precision. A theoretical analysis of the situation is carried out with the goal of overcoming them, and a new synchronization algorithm is proposed that is able to reach the desired resolution while getting rid of the restrictions on clock iii alignment that are imposed by virtually all usual schemes. Since the measurement of clock phase difference plays a crucial role in the proposed algorithm, extensions to the existing methods are defined and analyzed that improve them significantly. The proposed scheme for synchronism is validated using commercial evaluation boards.Taking the proposed synchronization method as a starting point, a DAQ architecture for PET is defined that is composed of two types of module (acquisition and concentration) whose replication makes it possible to arrange a hierarchic system of arbitrary size, and circuit boards are designed and commissioned that implement a realization of the architecture for the...

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New probe for the improvement of the Spatial Resolution in total-body PET (PROScRiPT)

et al. 2021

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In recent decades, PET scanners have been widely used for diagnosis and treatment monitoring in nuclear medicine. The continuous effort of the scientific community has led to improvements in scanner performance. Total-body PET is one of the latest upgrades in PET scanners. These kinds of scanners are able to scan the whole body of the patient with a single bed position, since the scanner tube is long enough for the patient to fit inside. While these scanners show unprecedented efficiency and extended field-of-view, a drawback is their low spatial resolution compared to dedicated scanners. In order to improve the spatial resolution of specific areas when measuring with a total-body PET scanner, the IRIS group at IFIC-Valencia is developing a probe. The proposed setup of the probe contains a monolithic scintillation crystal and a SiPM. The signal of the probe is read out by a TOFPET2 ASIC from PETsys, which has shown good performance for PET in terms of spatial and time resolutions. Furthermore, the PETsys technology generates a trigger signal that will be used to time synchronise the probe and the scanner. The proof-of-concept of the probe will be tested in a Preclinical Super Argus PET/CT scanner for small animals located at IFIC. Preliminary simulations of the scanner and the probe under ideal conditions show a slight improvement in the position reconstruction compared to the data obtained with the scanner, therefore we expect a considerable improvement when using the probe in a total-body PET scanner. Characterisation tests of the probe have been performed with a 22Na point-like source, obtaining an energy resolution of 9.09% for the 511 keV energy peak and a temporal resolution of 619 ps after time walk correction. The next step of the project is to test the probe measuring in temporal coincidence with the scanner.

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Evaluation of a high resolution silicon PET insert module

Cited by 12 publications

References 28 publications

Experimental evaluation of the resolution improvement provided by a silicon PET probe

Experimental evaluation of the resolution improvement provided by a silicon PET probe

Development of a data acquisition architecture with distributed synchronization for a Positron Emission Tomography system with integrated front-end.

New probe for the improvement of the Spatial Resolution in total-body PET (PROScRiPT)

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