Evaluation of a laparoscopic technique for collection of serial full-thickness small intestinal biopsy specimens in standing sedated horses

Bracamonte, José L.; Bouré, Ludovic; Geor, Raymond J.; Runciman, John; Nykamp, Stephanie; Cruz, Antonio; Teeter, Matthew G.; Waterfall, Heather L.

doi:10.2460/ajvr.69.3.431

Cited by 35 publications

(54 citation statements)

References 29 publications

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“…Furthermore, six mature (5-to 12-year-old) standardbred geldings with mean bodyweight (±SD) 453±28 kg were fed a controlled all-hay diet (2% of body weight (bwt) as timothy hay supplemented with vitamins and minerals) for 3 months (diet period 1) before harvest (biopsy 1 [B1]) of duodenal and ileal (at the junction of jejunum and ileum) mucosal biopsies via a laparoscopic technique [4] (Fig. 1 and Table 1).…”

Section: Animals and Collection Of Tissuementioning

confidence: 99%

Adaptive response of equine intestinal Na+/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate

Dyer

Al-Rammahi

Waterfall

et al. 2008

Pflugers Arch - Eur J Physiol

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Experimental and epidemiological evidence suggests that consumption of hydrolyzable carbohydrate, hCHO (grain), by horses is an important risk factor for colic, a common cause of equine mortality. It is unknown whether the small intestinal capacity to digest hCHO and/or to absorb monosaccharides is limiting, or even if horses can adapt to increased carbohydrate load. We investigated changes in the brush-border membrane carbohydrate digestive enzymes and glucose absorptive capacity of horse small intestine in response to increased hCHO. Expression of the Na(+)/glucose co-transporter, SGLT1, was assessed by Western blotting, immunohistochemistry, Northern blotting, QPCR, and Na(+)-dependent D-glucose transport. Glucose transport rates, SGLT1 protein, and mRNA expression were all 2-fold higher in the jejunum and 3- to 5-fold higher in the ileum of horses maintained on a hCHO-enriched diet compared to pasture forage. Activity of the disaccharidases was unaltered by diet. In a well-controlled study, we determined SGLT1 expression in the duodenal and ileal biopsies of horses switched, gradually over a 2-month period, from low (<1.0 g/kg bwt/day) to high hCHO (6.0 g/kg bwt/day) diets of known composition. We show that SGLT1 expression is enhanced, with time, 2-fold in the duodenum and 3.3-fold in the ileum. The study has important implications for dietary management of the horse.

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Section: Animals and Collection Of Tissuementioning

confidence: 99%

Adaptive response of equine intestinal Na+/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate

Dyer

Al-Rammahi

Waterfall

et al. 2008

Pflugers Arch - Eur J Physiol

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“…Although elegant laparoscopic intra‐abdominal intestinal biopsy techniques have been described (Schambourg and Marcoux ; Bracamonte et al . ), these procedures require the use of advanced laparoscopic intracorporeal suturing skills or expensive endoscopic linear staplers. Extra‐abdominal full thickness biopsy via flank laparotomy has been alluded to in several reviews (Mair ; Graham and Freeman ), yet there are no published reports citing the use of these techniques clinically.…”

Section: Discussionmentioning

confidence: 99%

Small intestinal biopsy and resection in standing sedated horses

Coomer¹,

McKANE²,

Roberts

et al. 2016

Equine Veterinary Education

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“…2008). In an experimental study by Bracamonte et al . (2008), an endoscopic linear stapling device was used for full thickness small intestinal biopsy in horses.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic assisted surgical removal of a congenital rectal hamartoma in a foal

Salazar

Caldwell

Joiner

et al. 2010

Equine Veterinary Education

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Summary In this report we describe a 3‐week‐old Paint horse filly that presented with rectal bleeding associated with a protruding mass. Rectal bleeding in neonates can be caused by infectious agents, trauma, congenital defects, rectal tears or tumours. Histopathology was performed on an avulsed piece of tissue. A second mass was identified endoscopically and was removed using a stapling instrument per rectum under endoscopic guidance and laparoscopic assistance. The mass was diagnosed as a rectal hamartoma. Recovery was uneventful.

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Evaluation of a laparoscopic technique for collection of serial full-thickness small intestinal biopsy specimens in standing sedated horses

Abstract: Laparoscopic collection of serial full-thickness small intestinal biopsy specimens with a 45-mm ELS may be an effective and safe technique for use in healthy adult experimental horses.

Cited by 35 publications

References 29 publications

Adaptive response of equine intestinal Na+/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate

Adaptive response of equine intestinal Na+/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate

Small intestinal biopsy and resection in standing sedated horses

Laparoscopic assisted surgical removal of a congenital rectal hamartoma in a foal

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