Evaluation of a Lectin-Based Imaging System for the Chairside Detection of Oral Dysplasia and Malignancy

Johnson, Alexander D.; Baeten, John; Patel, Ketan; Killian, Molly; Sunny, Sumsum; Suresh, Amritha; Uma, K.; Birur, Praveen; Kuriakose, Moni Abraham; Kademani, Deepak

doi:10.1016/j.joms.2019.03.012

Cited by 7 publications

(9 citation statements)

References 37 publications

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“…Among these, 193 were evaluated based on their titles and abstracts, which lead to an independent full-text review of 85 publications by two investigators. Following further screening based on predefined criteria, 56 publications were excluded, leaving 29 studies for qualitative synthesis ( Ma et al, 2014 , Ganga et al, 2017 , Sharma et al, 2022 , Neumann et al, 2022 , Nazir and Monalisa, 2020 , Morikawa et al, 2020 , Jayasinghe et al, 2020 , Bayad et al, 2019 , Johnson et al, 2019 , Chiang et al, 2019 , Deuerling et al, 2019 , Shi et al, 2019 , Bagga et al, 2017 , Popa et al, 2017 , Baeten et al, 2017 ; Yamamoto et al, 2017 , Lalla et al, 2016 , Kaur and Handa, 2016 , Nanayakkara et al, 2016 , Sawan and Mashlah, 2015 , Trakroo et al, 2015 , Awan et al, 2015 , Singh and Shukla, 2015 , Petruzzi et al, 2014 , Gupta et al, 2014 , Casparis et al, 2014 , Vashisht et al, 2014 , Suyambukesan et al, 2014 ). Inter-examiner reliability assessments for title/abstract screening and full-text evaluation resulted in kappa scores of 0.84 and 0.90, respectively, and any discrepancies were resolved with the involvement of a third reviewer.…”

Section: Resultsmentioning

confidence: 99%

“…Ganga et al demonstrated that the high negative predictive value of VELscope is useful for ruling out the existence of malignant transformations and can help reduce the anxiety of the patient and concerns of practitioners over clinically suspicious oral lesions ( Ganga et al, 2017 ). Two studies investigated the utility of the imaging technique by employing WGA-FITC ( Johnson et al, 2019 , Baeten et al, 2017 ). All investigations used biopsy and histopathological evaluation as reference tests ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review

Zabin Alotaibi,

Hameed Kolarkodi

2024

The Saudi Dental Journal

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review

Zabin Alotaibi,

Hameed Kolarkodi

2024

The Saudi Dental Journal

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“…Included studies (Table 1) were published between 2006 and 2020, and they were focused on the Autofluorescence technique (n:14) [28][29][30][31][32][33][34][35][36][37][38][39][40][41], HRME (n:5) [42][43][44][45][46], Optical spectroscopy (n:7) [10, [47][48][49][50][51][52], NBI (n:2) [53,54], and Vital Stain Colorants (n:6) [55][56][57][58][59][60]. In total, 34 studies were performed in adults (18 years of age or older).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…According to the Newcastle-Ottawa scale (NOS) on cross-sectional (n:24) [28,29,31,35,37,39,40,[42][43][44][45][46][48][49][50][54][55][56]59,60,[73][74][75][76]; case-control (n:10) [10,32,47,[51][52][53][77][78][79][80] and cohort studies (n:7) [30,34,36,38,41,57,58] the authors evaluated the qualities of all included studies based on object selection, comparability, and exposure. A star was described as an appropriate entry, with each star representing one point.…”

Section: Total Score=mentioning

confidence: 99%

In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

Mazur

Ndokaj

Venugopal

et al. 2021

IJERPH

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Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

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“…There is compelling evidence that topically applied fluorescently labelled lectins can identify areas of dysplasia. WGA binding decreases with increasing dysplasia in Barrett’s oesophagus (a premalignant state of oesophageal adenocarcinoma) [ 9 , 21 ], colorectal dysplasia [ 22 ] and oral dysplasia and malignancy [ 23 , 24 , 25 , 26 ]. In cervical cancer, markedly reduced sialylation was found in the glycoproteins of malignant tissue [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Lectins in Cervical Screening

Lim

Neves

Leen

et al. 2020

Cancers

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Cervical screening in low-resource settings remains an unmet need. Lectins are naturally occurring sugar-binding glycoproteins whose binding patterns change as cancer develops. Lectins discriminate between dysplasia and normal tissue in several precancerous conditions. We explored whether lectins could be developed for cervical screening via visual inspection. Discovery work comprised lectin histochemistry using a panel of candidate lectins on fixed-human cervix tissue (high-grade cervical intraepithelial neoplasia (CIN3, n = 20) or normal (n = 20)), followed by validation in a separate cohort (30 normal, 25 CIN1, 25 CIN3). Lectin binding was assessed visually according to staining intensity. To validate findings macroscopically, near-infra red fluorescence imaging was conducted on freshly-resected cervix (1 normal, 7 CIN3), incubated with topically applied fluorescently-labelled lectin. Fluorescence signal was compared for biopsies and whole specimens according to regions of interest, identified by the overlay of histopathology grids. Lectin histochemistry identified two lectins—wheat germ agglutinin (WGA) and Helix pomatia agglutinin (HPA)—with significantly decreased binding to CIN3 versus normal in both discovery and validation cohorts. Findings at the macroscopic level confirmed weaker WGA binding (lower signal intensity) in CIN3 vs. normal for biopsies (p = 0.0308) and within whole specimens (p = 0.0312). Our findings confirm proof-of-principle and indicate that WGA could potentially be developed further as a probe for high-grade cervical disease.

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Evaluation of a Lectin-Based Imaging System for the Chairside Detection of Oral Dysplasia and Malignancy

Cited by 7 publications

References 37 publications

Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review

Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review

In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

Lectins in Cervical Screening

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