Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid

Spindola, Rolff Ferreira; Macena, Cleidivan Silva; Contin, Andre; Luz, Rita de Cássia Silva; Damos, Flávio Santos

doi:10.1007/s10008-016-3451-9

Cited by 17 publications

(6 citation statements)

References 54 publications

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“…The lowest detectable concentration based on an S/N=3 was 0.5 μmol L −1 . The detection limit and the linear working range were compared with other analytical methods developed for the determination of INH (Table 1: [2, 4–6, 11, 53–61]). According to results in Table 1 it is observed that the proposed PEC sensor presented good results in comparison to the different methods developed for the determination of INH.…”

Section: Resultsmentioning

confidence: 99%

Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis

et al. 2021

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The present work describes the development of a photoelectrochemical sensor based on titanium dioxide, cadmium telluride quantum dots and the tris (2,2′‐bipyridyl) ruthenium(II) chloride complex for detection of Isoniazid (INH). The Ru(bpy)32+/CdTe‐QDs/TiO2/FTO photoelectrochemical platform was characterized by scanning electrochemical microscopy, electrochemical impedance spectroscopy and amperometry. The photoelectrochemical sensor presented two linear ranges for INH concentrations ranging from 0.5 to 150 μmol L−1 and 150 to 1270 μmol L−1, with a theoretical detection limit of 0.02 μmol L−1. The sensor was successfully applied for the determination of INH in drugs samples used in the treatment of tuberculosis.

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Section: Resultsmentioning

confidence: 99%

Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis

et al. 2021

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“…The electrochemical activity was tested by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Ferreira et al, (2016) developed an FePc/f-MWCNT/GC-modified electrode by polishing the surface of GCE using alumina slurry before the electrode was modified [ 29 ]. Then, the electrode was modified by a suspension that consisted of 2.0 mg f-MWCNT, 1.0 mg FePc, and 500 μL of dimethyl sulfoxide (DMSO).…”

Section: Sensor Applicationsmentioning

confidence: 99%

Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

et al. 2022

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Carbon nanomaterials have attracted researchers in pharmaceutical applications due to their outstanding properties and flexible dimensional structures. Carbon nanomaterials (CNMs) have electrical properties, high thermal surface area, and high cellular internalization, making them suitable for drug and gene delivery, antioxidants, bioimaging, biosensing, and tissue engineering applications. There are various types of carbon nanomaterials including graphene, carbon nanotubes, fullerenes, nanodiamond, quantum dots and many more that have interesting applications in the future. The functionalization of the carbon nanomaterial surface could modify its chemical and physical properties, as well as improve drug loading capacity, biocompatibility, suppress immune response and have the ability to direct drug delivery to the targeted site. Carbon nanomaterials could also be fabricated into composites with proteins and drugs to reduce toxicity and increase effectiveness in the pharmaceutical field. Thus, carbon nanomaterials are very effective for applications in pharmaceutical or biomedical systems. This review will demonstrate the extraordinary properties of nanocarbon materials that can be used in pharmaceutical applications.

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“…1−4 Isoniazid (INZ) is found to be an important antitubercular drug for anticipation and diagnosis of pulmonary tuberculosis (TB) along with pyrazinamide, rifampicin, and either ethambutol or streptomycin. 5 So far, many new patients each year are using INZ to treat TB as the safest, most effective method. In TB, the product quality should be retained for a longer period, for the patients may take the prescribed drug for longer time intervals.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the sensitive and selective identification of drugs used in medical applications for the treatment of tuberculosis is of great importance in biomedical and pharmaceutical research. − Isoniazid (INZ) is found to be an important antitubercular drug for anticipation and diagnosis of pulmonary tuberculosis (TB) along with pyrazinamide, rifampicin, and either ethambutol or streptomycin . So far, many new patients each year are using INZ to treat TB as the safest, most effective method.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these drawbacks, the electrochemical technique is an alternative. Such electrochemical methods have been widely employed for accurate real-time applications and good controllability for the detection of several electroactive drug components in biological fluids. , For these reasons, several modified electrodes, such as FePc/f-MWCNT, PdNPs/CILE, Ag–P(MMA-co-AMPS), carbon paste electrode (CPE), MWCNT-thionine, P Mel –Au nano , Co-FeHCF/MWCNT, multiwalled carbon nanotube (MWCNT)–chitosan (MWCNT–chit) composite, have been used for the determination of INZ. To date, MWCNTs were frequently used to deal with the electrical performance of INZ determination.…”

Section: Introductionmentioning

confidence: 99%

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Zinc and Sulfur Codoped Iron Oxide Nanocubes Anchored on Carbon Nanotubes for the Detection of Antitubercular Drug Isoniazid

Veerakumar

Sangili

Chen

et al. 2021

ACS Appl. Nano Mater.

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Zinc and sulfur codoped iron oxide nanocubes on functionalized multiwalled carbon nanotubes (Zn@S-FeNC/f-CNTs) were synthesized by a conventional hydrothermal (HT) route followed by ultrasonication, and the synthesized nanocomposites were used for the sensitive and selective detection of isoniazid (INZ). The morphological, structural, and electrochemical properties of the composite were well characterized. The application of the screen-printed carbon electrode modified with Zn@S-FeNC/f-CNT for the detection of antibiotic drug INZ (for the treatment of tuberculosis, TB) by employing voltammetric and amperometric techniques. The composite served as an outstanding electron (e − )-transfer mediator for INZ oxidation. Under optimum conditions, the modified electrode showed a distinct response for voltammetric and amperometric analyses toward INZ detection, yielding low detection limits of 5.01 and 8.54 nM, respectively. The calculated charge-transfer rate constant (k s ) was 1.6 × 10 −6 cm s −1 , while the electrochemical active surface area was estimated to be 0.157 cm 2 . The fabricated sensor exhibited good selectivity, long-term stability, and high reproducibility. The sensor has been further used to examine human serum and urine samples with good recovery.

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Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid

Cited by 17 publications

References 54 publications

Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis

Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis

Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

Zinc and Sulfur Codoped Iron Oxide Nanocubes Anchored on Carbon Nanotubes for the Detection of Antitubercular Drug Isoniazid

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