Evaluation of a novel ECG lead placement method in telemetered freely moving cynomolgus monkeys: Assessment of an intravascular biopotential lead

Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys

“…These implants however, quite often require a more invasive kind of surgery including ECG electrode placement on the diaphragm and in the jugular vein (Authier et al, 2011) and is therefore not considered appropriate for repeated dose toxicology studies requiring full histopathology evaluation. Although it has to be noted that subcutaneous lead placement is also still feasible and would avoid complicated surgical procedure (Yao et al, 2009) the implants used for this study are easy to implant and only require a minimal invasive approach.…”