Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Goertz, Ole; Ring, Andrej; Knie, Ulrich; Abels, Christoph; Daigeler, Adrien; Steinau, Hans-Ulrich; Steinstraesser, Lars; Langer, Stefan

doi:10.1159/000260040

Cited by 11 publications

(17 citation statements)

References 27 publications

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“…Its transparency allows a direct assessment of the wound. Our previous studies as well as the data obtained from other groups showed excellent results concerning toxicity and wound healing in experimental and clinical setups .…”

Section: Introductionsupporting

confidence: 59%

“…The purpose of this study was to examine the effects of polyhexanide ointment and chitosan solution on angiogenesis, epithelialisation and microcirculation in a standardised mouse model on fresh wounds . The wound model in hairless mice allows for qualitative and quantitative analysis of the wound microcirculation after topical application of different formulations and wound dressings .…”

Section: Discussionmentioning

confidence: 99%

“…Chitosan is a polysaccharide of randomly distributed β‐ ‐linked d ‐glucosamine. It is a natural material obtained from crustacean shells.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of angiogenesis, epithelialisation and microcirculation after application of polyhexanide, chitosan and sodium chloride in rodents

Goertz

Lauer

Hirsch

et al. 2015

International Wound Journal

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The purpose of this study was to investigate the effect of polyhexanide and a new developed chitin-based wound dressing on skin microcirculation, epithelialisation and angiogenesis. A full-thickness dermal layer extending to the underlying cartilage was excised on the dorsal side of hairless mice (n = 27; 2·3 ± 0·3 mm ). A polyhexanide ointment, a chitosan solution and a sodium chloride group as control were analysed using intravital fluorescence microscopy. Angiogenesis, epithelialisation and microcirculatory standard parameters were measured over a time period of 20 days. The non-perfused area is regarded as a parameter for angiogenesis and showed the following results: on days 12, 16 and 20, the sodium chloride group was significantly superior to chitosan solution (P < 0·05) and, on days 8, 12, 16 and 20, the polyhexanide group was superior to chitosan solution (P < 0·05). The epithelialisation was measured significantly faster in the polyhexanide and control group on day 8 versus chitosan solution. Whereas polyhexanide and sodium chloride were nearly completely epithelialised, treatment with chitosan solution showed still an open wound of 11% of the initial wound size. Altogether, we could demonstrate the advantageous effects of a polyhexanide ointment on microcirculation, angiogenesis and epithelialisation. Chitosan solution appears to inhibit angiogenesis and delays epithelialisation. Further studies in different models would be worthwhile to confirm these results.

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Section: Introductionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Evaluation of angiogenesis, epithelialisation and microcirculation after application of polyhexanide, chitosan and sodium chloride in rodents

Goertz

Lauer

Hirsch

et al. 2015

International Wound Journal

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“…Experimental data of the impact of wound gel on microcirculation and wound healing in mice in our research team showed no toxic effects [7] . Another study of our team found an integrity loss of the endothelium and a decrease in the functional vessel density after 1 hour of topical exposures in ears of mice [8] .…”

Section: Discussionmentioning

confidence: 94%

Clinical Safety and Efficacy of a Novel Thermoreversible Polyhexanide-Preserved Wound Covering Gel

et al. 2010

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Background: An ideal topical formulation for wound therapy does not exist. The aim of this study was to develop a novel improved therapeutic option for the treatment of acute and chronic wounds. Methods: A transparent wound gel which is in a liquid state below and in a gel state at or above room temperature was developed. Forty-four patients were included in this open randomized controlled single-center study. Flammazine™ served as control in the treatment of skin graft donor sites. Wounds were assessed for time of dressing change and overall satisfaction of patients and health care providers. The data were analyzed using the nonparametric Mann-Whitney test. Results: The wound gel proved to be superior in comparison with Flammazine with respect to wound assessment (p = 0.002), staining (p = 0.007), leaking (p = 0.032) and smell (p = 0.034). Flammazine showed favorable results regarding the parameters dehydration of the dressings (p = 0.012) and wound adherence (p = 0.005). The evaluation of the overall dressing change process showed no significant differences. Conclusion: The thermoreversible wound gel containing polyhexanide allows for good handling and wound assessment. This study demonstrated a high satisfaction level of patient and health care providers, and the wound gel proved an effective alternative to commonly used treatments.

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“…Flushing of deep wounds (e.g. bite injuries) with topically active strong protein-binding antiseptics is permissible only if drainage of the rinsing fluid is provided [11,33,[41][42][43][44][45] .…”

Section: The Role Of Polihexanide In Risk Woundsmentioning

confidence: 99%

Classification of Wounds at Risk and Their Antimicrobial Treatment with Polihexanide: A Practice-Oriented Expert Recommendation

Dissemond

Assadian

Gerber

et al. 2011

Skin Pharmacol Physiol

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Currently, there are no generally accepted definitions for wounds at risk of infection. In clinical practice, too many chronic wounds are regarded as being at risk of infection, and therefore many topical antimicrobials – in terms of frequency and duration of use – are applied to wounds. Based on expert discussion and current knowledge, a clinical assessment score was developed. The objective of this wounds at risk (W.A.R.) score is to allow decision-making on the indication for the use of antiseptics on the basis of polihexanide. The proposed clinical classification of W.A.R. shall facilitate the decision for wound antisepsis and allow an appropriate general treatment regimen with the focus on the prevention of wound infection. The W.A.R. score is based on a clinically oriented risk assessment using concrete patient circumstances. The indication for the use of antiseptics results from the addition of differently weighted risk causes, for which points are assigned. Antimicrobial treatment is justified in the case of 3 or more points.

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Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Cited by 11 publications

References 27 publications

Evaluation of angiogenesis, epithelialisation and microcirculation after application of polyhexanide, chitosan and sodium chloride in rodents

Evaluation of angiogenesis, epithelialisation and microcirculation after application of polyhexanide, chitosan and sodium chloride in rodents

Clinical Safety and Efficacy of a Novel Thermoreversible Polyhexanide-Preserved Wound Covering Gel

Classification of Wounds at Risk and Their Antimicrobial Treatment with Polihexanide: A Practice-Oriented Expert Recommendation

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