Evaluation of a Semi-Automated Multidimensional Gas Chromatography-Infrared-Mass Spectrometry System for Irritant Analysis

Multidimensional gas chromatography in food analysis

“…Combined with GC retention indices, a more informative conclusion as well as more confidence in the ultimate identification can be obtained. A typical hyphenation can be achieved by performing conventional GC or MDGC followed by post-column splitting at a suitable ratio (e.g., 10% v/v of the effluent to MS and the rest to FTIR [70]), prior to the synchronised detection with both MS and FTIR. One obvious advantage of the hyphenation of MS and FTIR is to avoid the ambiguity regarding which mass spectrum corresponds to which infrared spectrum, provided the respective compound is located in the MS or FTIR at the appropriate time; MDGC should assist to assuring this.…”

Molecular spectroscopy – Information rich detection for gas chromatography

“…Isomer identification [58] GC-FTIR Designer drugs Complimentary structural elucidation to GC-MS analysis [48] MDGC-FTIR-MS Fragrances Irritant identification using spectral library identification [234] GC-…”

“…This can also be achieved by using two identical columns, switching between two detectors with an open cross splitter, or running the effluent stream through serially linked detectors [234]. Employing cryogenic IR methods are useful to minimise sensitivity differences between the two detectors, but is not amenable to on-line methods.…”

Structure Elucidation Using Gas Chromatography−Infrared Spectroscopy/Mass Spectrometry Supported by Quantum Chemical IR Spectrum Simulations

“…MS is a favored technique to be operated in parallel with FTIR to provide complementary information of both molecular/fragment ion m / z data and spectroscopic vibrations/functional groups of the studied compounds. , Combined with GC retention index ( I ) data, , improved certainty and confidence in the identification of components have been proposed. Typical parallel detection can be achieved by performing conventional GC followed by postcolumn splitting in a suitable ratio (e.g., 90% v/v of the effluent to FTIR and the rest to MS), reported for a multidimensional GC experiment that improves isolation of individual compounds, with synchronized detection of both MS and FTIR channels.…”