Evaluation of a Veterinary Glucometer for Use in Horses

Hackett, Eileen S.; McCue, Patrick M.

doi:10.1111/j.1939-1676.2010.0481.x

Cited by 67 publications

(62 citation statements)

References 23 publications

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“…Lactate concentrations <0.8 mmol/L read as “low” and were assigned a value of 0.7 mmol/L for statistical analysis. Blood glucose concentration was measured on whole blood within 5 minutes of blood collection using a handheld blood glucose monitoring system that has been validated in horses . All lactate and glucose concentrations were determined in duplicate and averaged for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Mizen¹,

Woodman²,

Boysen

et al. 2016

Veterinary Internal Medicne

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BackgroundBlood lactate concentration is a marker of tissue perfusion and helps guide therapeutic interventions in critically ill horses. In both humans and dogs, administration of corticosteroids can increase blood lactate concentration, leading to type B hyperlactatemia. This effect could be a consequence of the impact of corticosteroids on glucose metabolism.ObjectivesTo investigate the effects of daily IM dexamethasone administration on blood lactate and glucose concentrations in horses.AnimalsNine healthy adult horses.MethodsA randomized, blinded, controlled, cross‐over study design was used. Horses were randomly assigned to 1 of 2 groups, either receiving 0.05 mg/kg of dexamethasone IM or an equivalent volume of saline, daily for 7 days. Blood was collected to determine lactate and glucose concentrations at baseline, 2 hours after the daily injections and 24 hours after the last injection.ResultsDexamethasone treatment had a statistically significant effect on lactate (P = .006) and glucose (P = .033) concentrations. The least squares mean lactate concentration was 0.93 mmol/L (95% CI: 0.87–0.99) in the dexamethasone group compared to 0.71 mmol/L (95% CI: 0.70–0.73) for the saline group. A positive relationship between blood lactate and glucose concentrations was identified, with a 0.07 mmol/L (95% CI: 0.05–0.09) increase in lactate concentration per unit increase in glucose (P < .0001) concentration.Conclusions and Clinical ImportanceDexamethasone induces statistically significant increases in blood lactate and glucose concentrations in healthy horses. Awareness of the potential for corticosteroids to induce type B hyperlactatemia might be important in the management of critically ill horses receiving dexamethasone.

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Section: Methodsmentioning

confidence: 99%

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Mizen¹,

Woodman²,

Boysen

et al. 2016

Veterinary Internal Medicne

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“…24,25 Urine creatinine concentration and GGT activity were measured (-24 and 24 hours) by use of an automated chemistry analyzer j with commercially available reagents and standards. Urine GGT (U/L)-to-creatinine (mmol/L) ratio was calculated.…”

Section: Administration Of Lps and Polymyxin B-mentioning

confidence: 99%

Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia

Wong¹,

Sponseller²,

Alcott³

et al. 2013

javma

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Objective—To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. Design—Prospective experimental study. Animals—14 healthy neonatal foals. Procedures—Foals were randomly assigned to a treatment or control group and were administered a single dose of lipopolysaccharide (0.5 μg/kg [0.23 μg/lb]) IV over 30 minutes. The treatment group received polymyxin B (6,000 U/kg [2,727 U/lb], IV) immediately after completion of lipopolysaccharide infusion; the control group was administered an equal volume of saline (0.9% NaCl) solution. Subsequent doses of polymyxin B or saline solution were administered IV at 8 and 16 hours. Blood was collected at various time points, and outcome variables, including heart rate, respiratory rate, rectal temperature, attitude score, WBC count, neutrophil count, lymphocyte count, monocyte count, platelet count, Hct, blood lactate concentration, blood glucose concentration, serum tumor necrosis factor-α concentration, and plasma thromboxane B2 concentration, were measured. Urine was collected prior to and after experimentation to determine whether nephrotoxicosis was associated with treatment. Results—The treatment group had significantly lower blood lactate concentration and serum tumor necrosis factor-α and plasma thromboxane B2 concentrations and had higher blood glucose concentrations and better attitude scores, compared with the control group, at various time points during the study. No other significant differences and no evidence of overt nephrotoxicosis were detected. Conclusions and Clinical Relevance—Administration of polymyxin B IV in healthy neonatal foals challenged with lipopolysaccharide attenuated some clinical and serum biochemical derangements associated with endotoxemia.

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“…Existen diversos valores reportados como normales en potros sanos, Koterba, Drummond, & Kosch (1990) 24 reportan como normal una glicemia de 101 y 227 mg/dL, Hackett & McCue (2010) 13 consideran normales rangos entre 143 -166 mg/ dL para potros de menos de un mes de edad, mientras que Muñoz, Riber, Trigo, & Castejòn (2012) 28 en un estudio realizado en potros españoles a distintas edades encontraron que potros sanos presentaban valores de 113,0-133,0 a una edad de 1 a 2 meses, 105,0-133,0 cuando tenían de 3 a 6 meses y 83,50-126,0 para potros de 6 a 9 meses.…”

Section: Discussionunclassified

“…El glucómetro fue calibrado justo antes de realizar cada prueba de acuerdo a las instrucciones del fabricante y todas las pruebas fueron realizadas con tirillas del mismo lote y número, según protocolo utilizado por Hug, Riond & Schwarzwald (2013) 13,19 . La medición de glucosa se realizó dentro de las dos primeras horas pos nacimiento antes de la primera lactancia (T0), posteriormente se realizaron tres mediciones a intervalos de tres horas.…”

Section: Materiales Y Métodosunclassified