Evaluation of Acute and Subchronic Toxicity of Silver Nanoparticles in Normal and Irradiated Animals

Amin, Yara M.; Hawas, Asrar M.; El-Batal, Ahmed I.; Hassan, S; El-Sayed, Mohamed

doi:10.19026/bjpt.6.5188

Cited by 24 publications

(11 citation statements)

References 24 publications

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“…Infiltrations of the seminiferous tubule observed in mice after exposure to varying concentrations of AgNPs may possibly suggest that genotoxic effects of AgNPs. This result is consistent with a study carried out by Amin, et al, (2015) which reported that accumulation of silver in different organs occurred in the order; lung>liver>-kidney>testes. The enlarged and irregular sinusoidal spaces observed in liver of exposed mice could be due to degeneration of the hepatocytes caused by the genotoxic action of the AgNPs.…”

Section: Discussionsupporting

confidence: 93%

Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

Iyiola

Olafimihan

2018

URJ

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Silver nanoparticles (AgNPs) are widely used in industrial and medical applications. However, there is a growing concern about the potentialities of AgNPs to induce genotoxicity and DNA damage in humans. In this study, genotoxic and histopathological effects of AgNPs were investigated in mice using two well-characterized genetic assays: mouse bone marrow micronuclei (MN) and mouse sperm morphology assays. Swiss albino mice (total N=18) were exposed to varying concentrations (3,000mg/Kg, 4,000mg/Kg, 5,000mg/Kg and 6,000mg/Kg) of AgNPs for 5 consecutive days and observed for 30 days afterwards. Distilled water and colchicine were used as negative and positive controls, respectively. The MN assay showed that the frequency of micronuclei induction increased with AgNP concentration. Statistically significant differences (p<0,05) were observed for the micronucleus frequency in the blood erythrocytes in all the test concentrations. Sperm head morphology assay also revealed various types of abnormal sperm head morphology and there was statistically significant increase in frequency of sperm abnormalities. Histopathological profiles of the liver also showed enlarge sinusoids, irregular portal tract, and dose-dependent vacuolation. These results suggest that AgNPs is genotoxic and represent a serious health risk to human heatlh.

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Section: Discussionsupporting

confidence: 93%

Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

Iyiola

Olafimihan

2018

URJ

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“…To study the particles size and morphology, the aqueous dispersion of the nanoparticles was drop-cast onto a carbon-coated copper grid [30,31] .…”

Section: Nanoparticle Characterizationmentioning

confidence: 99%

CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study

Gawish

Shaban

Aal

et al. 2019

Journal of Medical Histology

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Background: Silver nanoparticles (Ag-Nps) and Titanium dioxide nanoparticles (TiO2-Nps) are well-known nanoproducts. Both of them have many industrial applications. Lung is one of the major target organs for prolonged nanoparticles exposure. Objective: This study was designed to investigate and compare the possible histopathological toxic effect of Ag-Nps & TiO2-Nps on lung and which of them is safer for future using. Materials & methods: 54 adult male albino rats were divided into 3 equal groups; GroupI (control group), Group II that subdivided into two subgroups; Subgroup IIa: Ag-Nps group with (100 mg/kg/day) daily for 4 successive weeks and Subgroup IIb recovery group left for 4 weeks without injection, Group III that subdivided into two subgroups; Subgroup IIIa: TiO2-Nps group with (150 mg/kg/day) for 4 successive weeks and Subgroup IIIb recovery group left for 4 weeks without injection. Lung specimens were processed for light and electron microscope and immunohistochemical expression of caspase-3 and CD-68. Morphometric and statistical analysis were performed. Results: Group IIa showed collapsed alveoli, others showed ballooned distension and marked thickening of inter-alveolar septa. Extensive cellular infiltration was detected. Group IIIa showed focal areas of collapsed alveoli and thick inter-alveolar septa. Mild cellular infiltrations were observed. Areas of extravasation were detected in the interstitium. Group IIIb showed signs of improvement which is more than group IIb. Conclusion: exposure to Ag-Nps showed marked alterations on histological structure of lung, which is more than the alteration caused by TiO2-Nps; in addition, recovery period was proved to ameliorate these changes better in TiO2-Nps.

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“…Despite the evolution of research in nanotechnology, there remain considerable challenges to overcome, including safety, scale-up production, decreasing costs, and understanding the biological activity. 18 Nowadays, the safety concerns of using metal oxide NPs are considered one of the main future challenges for biomedical applications. 18 Here, we tried to decrease the toxicity of the prepared metal oxide NPs by incorporation with a resistantnystatin drug to increase the synergistic effect and decrease the necessary applied-dose in order to reduce the nanotoxicity, which means reducing the negative inuence of the metal oxide NPs on the biological organisms.…”

Section: Introductionmentioning

confidence: 99%

“…18 Nowadays, the safety concerns of using metal oxide NPs are considered one of the main future challenges for biomedical applications. 18 Here, we tried to decrease the toxicity of the prepared metal oxide NPs by incorporation with a resistantnystatin drug to increase the synergistic effect and decrease the necessary applied-dose in order to reduce the nanotoxicity, which means reducing the negative inuence of the metal oxide NPs on the biological organisms. 18,19 Bi 2 O 3 NPs have a large surface area with various electrochemical balances and they have delivered important attention due to their potential applications for zinc sensing.…”

Section: Introductionmentioning

confidence: 99%

“…18 Here, we tried to decrease the toxicity of the prepared metal oxide NPs by incorporation with a resistantnystatin drug to increase the synergistic effect and decrease the necessary applied-dose in order to reduce the nanotoxicity, which means reducing the negative inuence of the metal oxide NPs on the biological organisms. 18,19 Bi 2 O 3 NPs have a large surface area with various electrochemical balances and they have delivered important attention due to their potential applications for zinc sensing. 20 Owing to their unique properties (non-toxic behavior, biocompatibility, and high chemical stability), they have been used as antibacterial and antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

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Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

et al. 2020

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Evaluation of Acute and Subchronic Toxicity of Silver Nanoparticles in Normal and Irradiated Animals

Cited by 24 publications

References 24 publications

Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

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