Evaluation of aging vs dementia by means of neurosonology

Demarin, Vida; Kes, Vanja Bašić; Morović, Sandra; Zavoreo, Iris

doi:10.1016/j.jns.2009.02.006

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…Confirming previous study results [14][15][16] we found increased RI and PI in the MCA indicating reduced distal vascular compliance in patients with WMD which has been thought to be consistent with the development of small vessel cerebral disease. These findings remained significant after adjusting for all vascular risk factors.…”

Section: Discussionsupporting

confidence: 91%

Retinal vasoreactivity as a marker for chronic ischemic white matter disease?

Bettermann

Slocomb

Shivkumar

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 91%

Retinal vasoreactivity as a marker for chronic ischemic white matter disease?

Bettermann

Slocomb

Shivkumar

et al. 2012

Journal of the Neurological Sciences

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“…Our results are in good correlation with the results of the previous epidemiological studies and once again confirm a strong impact of the modifiable risk factors on cerebrovascular disease and cognitive decline [5,7,9]. In our study there was no subjects with arterial hypertension, diabetes mellitus or atrial fibrillation and hyperlipidemia was present in 1 case and was medically regulated in the group of young healthy volunteers, while in other groups these risk factors were present in greater amount, and especially not treated medically adequate in the group of MCI subjects [10][11][12][13].…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies as well as our results suggest that mechanical arterial properties (changes in BHI) are affected first with aging while hemodynamic remains mostly preserved (mean velocities were unchanged or slightly changed due to cerebral autoregulation mechanisms) in healthy individuals [7,8,[23][24][25].…”

Section: Discussionsupporting

confidence: 73%

“…We have recorded a decreasing trend in the BHI values of older group without MCI, but it was not statistically significant (p N 0.05), probably due to the normal physiologic changes that are present as a part of a cardiovascular aging [7,8].…”

Section: Discussionmentioning

confidence: 76%

“…We have found that there is decrease in BHI values according to age while mean blood flow velocities remain unchanged. These results suggest that there is a decrease in the cerebral autoregulation due to aging, in this case atherosclerotic changes and decrease of elasticity of intracranial small vessels walls [7][8][9]. In this study we try to evaluate correlation of BHI as a marker of early changes in intracranial hemodynamic and changes in cognitive tests (MMSE and MoCA) suggesting MCI as a transitional state between normal aging and vascular dementia (subclinical form of dementia).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breath holding index in detection of early cognitive decline

Zavoreo

Kes

Morović

et al. 2010

Journal of the Neurological Sciences

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Cognitive decline and cerebral vasoreactivity in asymptomatic patients with severe internal carotid artery stenosis

et al. 2013

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The aim of the study was to correlate cognitive decline and cerebral vasoreactivity in 150 asymptomatic right-handed patients with severe ≥70% unilateral internal carotid artery (ICA) stenosis and to evaluate the role of intracranial collateral circulation during cognitive testing. Cognitive assessment was performed by means of Montreal Cognitive Assessment (MoCA) and Mini Mental State Exam (MMSE) scales. Cerebrovascular reactivity (CVR) and intracranial collateral circulation were evaluated by means of breath holding index (BHI) and transcranial color Doppler (TCD) sonography. The results were compared with 150 right-handed controls matched for demographic variables and vascular risk factors. Patients with severe unilateral ICA stenosis had MMSE scores within a normal range, but MoCA scores were lower than normal. By examining the side of the observed stenosis, it has been noted that patients with left-sided ICA stenosis had lower MoCA scores in categories of language and episodic memory performance, while patients with right-sided ICA stenosis had lower MoCA scores in a category of visual-spatial skills. All patients had BHI values lower than normal. Subjects with a single intracranial collateral artery recruited had slightly better cognitive results than the patients with two or more collateral arteries activated. Results of the study showed that altered cerebrovascular reactivity and cerebral hypoperfusion might be responsible for the reduction of specific cognitive functions ipsilateral to the ICA stenosis, therefore BHI and MoCA might be useful tools when screening for cognitive decline in asymptomatic patients with severe ICA stenosis.

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Evaluation of aging vs dementia by means of neurosonology

Cited by 15 publications

References 40 publications

Retinal vasoreactivity as a marker for chronic ischemic white matter disease?

Retinal vasoreactivity as a marker for chronic ischemic white matter disease?

Breath holding index in detection of early cognitive decline

Cognitive decline and cerebral vasoreactivity in asymptomatic patients with severe internal carotid artery stenosis

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