Evaluation of algorithms to identify incident cancer cases by using French health administrative databases

Ajrouche, A.; Estellat, Candice; Rycke, Yann De; Tubach, Florence

doi:10.1002/pds.4225

Cited by 19 publications

(20 citation statements)

References 36 publications

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“…Information on both aspirin use and cancer were prospectively collected for an administrative purpose and thus independently of any prespecified hypothesis. Moreover, the validated algorithm we used to identify incident cancer cases in the SNDS databases allowed us to avoid any outcome misclassification . In addition, we restricted our study to only LDA in terms of clinical relevance in prevention (established antiplatelet effect in preventing cardiovascular disease and low rate of bleeding below 325 mg) .…”

Section: Discussionsupporting

confidence: 89%

“…Moreover, the validated algorithm we used to identify incident cancer cases in the SNDS databases allowed us to avoid any outcome misclassification. 36 In addition, we restricted our study to only LDA in terms of clinical relevance in prevention (established antiplatelet effect in preventing cardiovascular disease and low rate of bleeding below 325 mg). 47 Finally, the cumulative protective effect of aspirin observed for each additional year of exposure was an additional argument favoring the causality of the observed protective effect of LDA on overall cancer incidence.…”

Section: Discussionmentioning

confidence: 99%

“…We also considered the first occurrence of prostate and breast cancer incidence, using the same validated algorithm mentioned above, but restricted to only prostate and breast cancer codes, respectively …”

Section: Methods (More Details Are Presented In Appendix A)mentioning

confidence: 99%

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Reduced risk of cancer among low‐dose aspirin users: Data from French health care databases

Ajrouche

Rycke

Dalichampt

et al. 2019

Pharmacoepidemiology and Drug

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Purpose The effect of chronic use of low‐dose aspirin (LDA) on overall cancer is still unclear owing to many controversial results and methodological limitations of studies. This study aimed to assess the effect of LDA use on overall cancer incidence among the French population. Methods We conducted a 10‐year historical cohort study using the permanent sample of the French national health care databases: the Système National des Données de Santé (SNDS). We used data for 111 025 individuals aged 50 to 80 years at study entry (January 1, 2006) without prevalent cancer or LDA use. Individuals were followed until the earliest of cancer incidence, death from any cause, exit from the database, or end of the study on December 31, 2015. We estimated the effect of LDA on cancer incidence by using a dynamic model to account for the competing risk of death in the presence of time‐dependent exposure and risk factors. Results LDA use was associated with reduced 10‐year risk of cancer (subdistribution hazard ratio [SHR] 0.81 [95% CI 0.77‐0.86]). The SHRs were 0.88 [0.82‐0.94] for men and 0.93 [0.85‐1.02] for women. Moreover, each additional year of LDA use was associated with reduced 10‐year risk of cancer (SHR 0.93 [0.92‐0.95]). LDA use was also associated with reduced 10‐year risk of death (SHR 0.86 [0.82‐0.91]). Conclusions This is the first population‐based study to demonstrate a protective effect of LDA on overall cancer incidence and to account for the main methodological issues of previous observational studies.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Reduced risk of cancer among low‐dose aspirin users: Data from French health care databases

Ajrouche

Rycke

Dalichampt

et al. 2019

Pharmacoepidemiology and Drug

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“…Previously developed algorithms were used to define each indication or comorbidity and combined information from drug reimbursements, medical procedures (CCAM), hospital and LTD diagnosis 39,40 . Supplemental codes of identification for comorbidities are presented in the supplemental material.…”

Section: Low Socioeconomic Status Defined By the Complementary Univementioning

confidence: 99%

“…On multinomial logistic regression, the absence of a secondary indication for LDA use at baseline was the main predictor of being in the not-adherent, delayed notadherent or delayed adherent versus persistent adherent group (OR 0. 40 (table 3). Moreover, the probability of being not-adherent was increased with female sex, low socioeconomic status and polymedication the year before the index event and was decreased with diabetes, hypertension, dementia, ≥ 4 physician consultations in the previous year, and at least one hospitalization or one cardiologist consultation in the previous 3 months (Table 3).…”

Section: Predictors Of Adherencementioning

confidence: 99%

Trajectories of Adherence to Low-Dose Aspirin Treatment Among the French Population

Ajrouche

Estellat

Rycke

et al. 2019

J Cardiovasc Pharmacol Ther

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Background: Previous studies have shown that adherence to low-dose aspirin (LDA) is suboptimal. However, these studies were based on an average measure of adherence during follow-up, ignoring its dynamic process over time. We described the trajectories of adherence to LDA treatment among the French population over 3 years of follow-up. Methods: We identified a cohort of 11 793 new LDA users, aged ≥50 years in 2010, by using the French national health-care database. Patients included had at least 3 years of history in the database before study entry to exclude prevalent aspirin users and to assess baseline comorbidities. They were followed from the first date of LDA supply (the index date) until the first date among death, exit from the database, or 3 years after the index date. Adherence to LDA was assessed every 3 months by using the proportion of days covered (PDC) and dichotomized with a cutoff of PDC of 0.8. We used group-based trajectory modeling to identify trajectories of LDA adherence. Predictors of LDA adherence trajectory membership were identified by multinomial logistics regression. Results: We identified 4 trajectories of adherence among new LDA users: the not-adherents (4737 [40.2%]), the delayed not-adherents (gradual decrease in adherence probability, 1601 [13.6%]), the delayed adherents (gradual increase in adherence probability, 1137 [9.6%]), and the persistent adherents (4318 [36.6%]). The probability of belonging to the not-adherent group was increased with female sex, low socioeconomic status, and polymedication and was reduced with a secondary indication for LDA use, such as diabetes, hypertension, and dementia, at least 4 consultations in the previous year, or 1 hospitalization or a cardiologist consultation in the 3 months before the index date. Conclusion: This study provides a dynamic picture of adherence behaviors among new LDA users and underlines the presence of critical trajectories that intervention could target to improve adherence.

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Implementing Indicators and Trajectories of Return to Work After Breast Cancer Diagnosis: A Mixed-Methods Study Using the French National Healthcare Insurance Database and Stakeholder Consultation

Varnier,

Moskal,

Bodelet

et al. 2024

Clinical Breast Cancer

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Evaluation of algorithms to identify incident cancer cases by using French health administrative databases

Abstract: The algorithms proposed could be used for cancer incidence monitoring and for future etiological cancer studies involving French healthcare databases. Copyright © 2017 John Wiley & Sons, Ltd.

Cited by 19 publications

References 36 publications

Reduced risk of cancer among low‐dose aspirin users: Data from French health care databases

Reduced risk of cancer among low‐dose aspirin users: Data from French health care databases

Trajectories of Adherence to Low-Dose Aspirin Treatment Among the French Population

Implementing Indicators and Trajectories of Return to Work After Breast Cancer Diagnosis: A Mixed-Methods Study Using the French National Healthcare Insurance Database and Stakeholder Consultation

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