Evaluation of anti-ulcer activity of the leaf extract of &lt;em&gt;Osyris quadripartita&lt;/em&gt; Decne. (Santalaceae) in rats

Abebaw, Mastewal; Mishra, Bharat; Gelayee, Dessalegn Asmelashe

doi:10.2147/jep.s125383

Cited by 71 publications

(78 citation statements)

References 20 publications

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“…The total acidity value was higher in the group A (negative control) and group B (positive control) when compared to group C (standard drug control) and group D (extract treated) (P value < 0.05) as shown in Figure 3 and Table III. Our fi ndings were in accordance with all of the previous studies which have been performed to measure the diff erence between pH and total acidity of animals of disease and extract treated groups (Abebaw et al 2017, Chatterjee et al 2012, Pradhan et al 2013.…”

Section: Resultssupporting

confidence: 91%

Evaluation of Gastro-protective Activity of Myristica fragrans on Ethanol-induced Ulcer in Albino Rats

Sattar

Abdo

Mushtaq

et al. 2019

An. Acad. Bras. Ciênc.

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Myristica fragrans seeds are traditionally used to treat dyspepsia, vomiting and abdominal pain. The purpose of this study was to investigate the protective effect of Myristica fragrans in ethanol induced gastric ulcer. Study was carried out on rats, divided into four groups; negative control, positive control, standard drug control, and Myristica fragrans extract treated rats. The pH, ulcer index, acidity values and histopathological examination of stomach were evaluated. Myristica fragrans significantly (P<0.05) reduced gastric lesions by 41.68% in ethanol induced ulcer model at 200 mg/kg when compared to sucralfate (60.41%). However, histopathological findings appeared similar in Myristica fragrans extract treated and standard drug control groups, where stomachs were found with mild erosion of superficial epithelium and few infiltrated inflammatory cells. pH of gastric contents of rats from extract treated was increased (4.25 ± 0.25) as compared to positive control group (2.25 ± 0.25). Ulcer index of extract treated rats was improved (41.74%). Moreover, total acidity of extract treated group (60.0 ± 0.47) was decreased as compared to control group (74.50 ± 1.04). It is concluded that Myristica fragrans showed significant protecting activity in ethanol induced ulcer. Isolation and purification of phytochemicals responsible for gastroprotective activity becomes necessary.

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Section: Resultssupporting

confidence: 91%

Evaluation of Gastro-protective Activity of Myristica fragrans on Ethanol-induced Ulcer in Albino Rats

Sattar

Abdo

Mushtaq

et al. 2019

An. Acad. Bras. Ciênc.

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“…It was also reported that intragastric administration of absolute ethanol in rats increases the levels of VEGF, [22,23] TNF α, and MDA in gastric tissue homogenates. [24,25] Pretreatment of rats with graded doses of the ethanol stem bark extract of B. dalzielii H provided cytoprotection, signifi- cantly decreased (p<0.0001) gastric ulcer index, and ameliorated gastric mucosal injury by ethanol in a dose-dependent manner when compared to ethanol control. The treatment also significantly increased (p<0.001) the SOD, CAT, and TAC levels when compared with control.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Vascular Endothelial Growth Factor (VEGF) and Tissue Necrosis Factor Alpha (TNFα) by the Ethanol Stem Bark Extract of Boswellia dalzielli H Attenuates Ethanol Induced Gastric Ulcer in Albino Rats.

Yusuf

Salami

Babakura

et al. 2018

EJMO

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Objectives:The modulation of vascular endothelial growth factor, antioxidants, and tissue necrosis factor alpha (TNF-α) using ethanol stem bark extract of Boswellia dalzielii H. was evaluated in an ethanol-induced gastric ulcer albino rat model. Methods: Thirty albino rats of either sex (200-250 g) were starved for 48 h but were allowed drinking water with 8% sucrose to avoid dehydration. The rats were placed on wire gauze above the base of the cage to prevent coprophagy. At the end of the fasting period, the rats were equally divided and assigned to six treatment groups. Group A served as control and 5 ml/kg distilled water was orally administered to the rats without further treatment. Rats in group B were given 5 ml/kg distilled water and served as negative control. Rats in groups C, D, and E were pretreated with 100, 200, and 400 mg/kg of the ethanol stem bark extract of B. dalzielii H, respectively. Group F received 50 mg/kg ranitidine. After 1 h, all the rats in groups B-F were each given absolute ethanol 1 ml/200 g body weight of rat. All treatments were by intragastric lavage. One hour after the treatment with ethanol, all the rats in the experiment (groups A-F) were euthanized with an overdose of anesthetic ether and their stomachs were excised. The stomachs were cut along the greater curvature and washed in warm normal saline. Each stomach was stretched out and pinned on board. Results:The results of the study revealed that pretreatment with ethanol stem bark extract of B. dalzielii H. decreased gross and histological gastric mucosal damage caused by intragastric administration of absolute ethanol in a dosedependent manner when compared with controls. The gastric ulcer index and gastric tissue level of malondialdehyde (MDA) and TNF-α were significantly reduced (p<0.001), whereas the gastric tissue level of superoxide dismutase, catalase, total antioxidant capacity, and vascular endothelial growth factor (VEGF) was significantly increased (p<0.001) when compared with the controls. Conclusion: The plant extract attenuated gastric mucosal damage induced by ethanol via upregulation in the expression of gastric tissue VEGF, reinforcement of the antioxidant system, and reduction in the gastric tissue level of MDA and the pro-inflammatory cytokine TNF-α.

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“…ex Decne is a plant native of Africa, southwestern Europe and Asia, commonly known as wild tea and widely used in Ethiopian folk medicine. A study evaluated the antiulcer activity of 80% methanol leaf extract from O. quadripartita in Wistar albino rats, using pylorus ligation-induced and ethanol-induced models, both applying a single (100, 200, 400 mg/kg) and repeated dosing (200 mg/kg for 10 and 20 days) approaches [ 101 ]. The extract reduced gastric ulcer index in both models at 400 mg/kg dose, which is comparable to the standard drugs, ranitidine (50 mg/kg) and sucralfate (100 mg/kg).…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

“…Moreover, the study showed that the extract exerted both dose- and time-dependent antiulcer effects in both models. Additionally, the oral median lethal dose (LD 50 ) was estimated to be higher than 2000 mg/kg and where secondary metabolites, including flavonoids, tannins and saponins were detected in the extract [ 101 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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Evaluation of anti-ulcer activity of the leaf extract of <em>Osyris quadripartita</em> Decne. (Santalaceae) in rats

Cited by 71 publications

References 20 publications

Evaluation of Gastro-protective Activity of Myristica fragrans on Ethanol-induced Ulcer in Albino Rats

Evaluation of Gastro-protective Activity of Myristica fragrans on Ethanol-induced Ulcer in Albino Rats

Modulation of Vascular Endothelial Growth Factor (VEGF) and Tissue Necrosis Factor Alpha (TNFα) by the Ethanol Stem Bark Extract of Boswellia dalzielli H Attenuates Ethanol Induced Gastric Ulcer in Albino Rats.

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

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