Evaluation of Antimicrobial Activities and Bioactive Compounds of Different Extracts Related to Syrian Traditional Products of Damask Rose (Rosa damascena)

Thallaj, Nasser; Agha, Mohamed Isam Hasan; Nattouf, Abdul Hakim; Khatib, Chadi; Karaali, Ahmad; Moustapha, Aoula; Labban, Louay

doi:10.4236/oalib.1106302

Cited by 17 publications

(14 citation statements)

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“…damascena Mill L. is one of the most important plants of the Rosaceae family and the subfamily is Rosoideae. It is a cross between Rosa phoenicia and Rosa gallica [1][2][3][4]. ere are approximately more than 1800 different cultivars of the plant, including more than 200 species of roses [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Geraniol, one of the main components of R. damascena, exerts its effects in a variety of ways [4]. Rose essential oil has also been linked to antidepressant, epileptic, and reproductive benefits, as well as antiallergic, anticephalic, and antimigraine effects [2,4,10].…”

Section: Introductionmentioning

confidence: 99%

“…Several phenolic compounds are also present in the Damask rose and include flavonoids [2,10,13,14]. One study found that fresh flower extracts contained quercetin, whereas spent flower extracts also contained epicatechin.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical, Physiochemical, Macroscopic, and Microscopic Analysis of Rosa damascena Flower Petals and Buds

Abudayeh

Karpiuk

Armoon

et al. 2022

Journal of Food Quality

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Macroscopic and microscopic analysis of R. damascena buds and flower petals was used to find the main morphological and anatomical features of these types of medicinal plant material (MPM). The presence of polysaccharides, free and bound monosaccharides, tannins, flavonoids, saponins, and essential oils was confirmed by chemical and histochemical reactions. The quality indicator of R. damascena buds and flower petals was evaluated in this study; weight loss on drying gave the next result: 6.69 ± 0.20% for flower petals and 6.65 ± 0.13% for buds. The swelling index showed a high result for R. damascena flower petals and buds. R. damascena buds swelling index—5 ± 0.2 and R. damascenaflower petals swelling index—15 ± 0.6. The determination of volatile substances by GC/MS shows the presence of 18 volatile compounds in flower petals and buds, this number varies up to 17. Nonadecane, heneicosane, and octadecane are the main components in both medicinal plant materials. Both buds and flower petals contain approximately the same amount of citronellol. Phenylethyl alcohol is present in large amounts in buds but in small amounts in flower petals. R. damascena flower petals and buds are the sources of volatile compounds, phenols, and polysaccharides. The results of our investigation showed great differences and similarities between buds and flower petals of R. damascena. We have confirmed that not only buds but also flower petals could be a source of biologically active substances (BASs) such as essential oils, polysaccharides, and phenolic compounds. Flower petals could be an alternative MPM. We would also like to underline the importance of standard documentation for MPM: its macro and microscopic description, harvest time, control techniques of the qualitative composition, and the quantitative content of the main BAS. Because it will help in the production of various high-quality products that can be used in medicine, pharmacy, food, and the perfume industries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical, Physiochemical, Macroscopic, and Microscopic Analysis of Rosa damascena Flower Petals and Buds

Abudayeh

Karpiuk

Armoon

et al. 2022

Journal of Food Quality

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“…Ginger consists of a biologically active combination of constituents such as gingerols, shogoals and paradols which have for the majority of its anti-inflammatory properties. [10] With regard to the medicinal properties, ginger exhibits antispasmodic and anti-inflammatory activity, helps reduce cholesterol, lower blood pressure and shrink liver tumor in test animals. In humans, rhizome powder is effective against nausea, for example, post-operative nausea, motion sickness and morning sickness.…”

Section: Introductionmentioning

confidence: 99%

“…Preclinical research has shown that ginger inhibits cyclooxygenase, lipooxygenase, resulting in suppression in the synthesis of the inflammatory leukotrienes. [10] Furthermore, Ginger extracts found to inhibit the expression of tumor necrosis factor (TNF)-α in synoviocytes activated by either TNF-α or interleukin (IL)-1β, [11,12] and in one study a ginger extracts showed an antiinflammatory effect of betamethasone. [13] On the other hand, Echinacea is a plant which is native to North America where they grow in prairies and open, wooded areas.…”

Section: Introductionmentioning

confidence: 99%

Pain Relieving Properties of Ginger (Z. officinale) and Echinacea (E. angustifolia) Extracts Supplementation among Female Patients with Osteoarthritis. A Randomized Study

Labban¹,

Kudsi²,

Malek³

et al. 2020

AMDHS

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Objectives: To evaluate the efficacy and safety of the Echinacea and ginger species extracts supplementation among patients with knee osteoarthritis (OA). Methods: Three hundred female patients with knee OA participated in this randomized study. They had OA of the knee and moderate-to-severe pain and they were divided into two groups. Study group (n=150) and control group (n=150). The study which lasted for 6-week. The study group received Ginger and Echinacea extract supplementations twice daily, with/ without acetaminophen. The study examined the reduction in "knee pain on standing for the study group (Ginger and Echinacea group)" defined by a reduction in pain of > or = 15 mm on a visual analog scale. The study measured other biological values such as BP, ESR, Creatinine and liver enzymes. Results: The supplementation of ginger and Echinacea extracts resulted in improvements in many values. Systolic blood pressure dropped from 120.5 ± 10.4 to 119.7 ± 8.9 mmHg, pain intensity VAS decreased from 6.9 ± 2.1 to 6.6 ± 1.5, ESR17.3 ± 11.9 and 21.0 ± 9.8mm/h, creatinine 0.87 ± 0.19mg/dl and 0.85 ± 0.16 mg/ dl and liver enzymes 21.6 ± 8.5 IU/L and 20.9 ± 4.5 IU/L for ALT and 20.9 ± 4.5 IU/L and 20.3 ± 7.4 IU/L for AST. Conclusion: The use of ginger extract in knee osteoarthritis patients had a moderately statistically significant effect on reducing pain with safe profile and mild GI adverse events.

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Pharmaceutical Potential Evaluation of Damask Rose By-Products from Volatile Oil Extraction

Charoimek,

Sunanta,

Tangpao

et al. 2024

Plants

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Despite its well-known fragrance in cosmetics and medicine, a complete understanding of the phytochemical properties within by-products generated during commercial extraction of Damask rose remains elusive. Cultivated in Thailand for their essential oil, Damask rose varieties, including Mon Dang Prasert, Mon Klai Kangwon, and Bishop’s Castle, share phenylethyl alcohol (57.62–61.11%) as the dominant component, which is responsible for their characteristic floral, sweet, rosy, and bready aroma. Through a circular hydro-distillation process, three different by-product fractions, including distilled water (D), hydrosol (H), and rose dreg (R), were recovered. Subsequently, we assessed their pharmaceutical potential, including the antioxidant, antimicrobial, anti-inflammatory, and anti-melanogenesis properties of these residual substances. The H fraction displayed the highest total phenolics (10.56 mgGAE/g) and flavonoids (6.93 mgCE/g) and significant antioxidant activity (IC50, 0.67–0.97 µg/mL). While the H fraction inhibited melanin formation at 50 μg/mL, the R fraction of MK (100 μg/mL) surprisingly promoted melanin production in B16-F10 cells. Nevertheless, the antimicrobial assay against Staphylococcus aureus, Cutibacterium acnes, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans revealed no antimicrobial activity in any fraction. Murine macrophage stimulation (J774A.1) with lipopolysaccharide revealed no anti-inflammatory effects from the by-products, as measured by IL-1β production. In summary, the H fraction exhibited the highest level of phenolic and flavonoid contents, as well as antioxidant and anti-melanogenesis activities. Therefore, this by-product is a desirable choice for the development of value-added products such as functional food, cosmetics, and pharmaceutical products.

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Evaluation of Antimicrobial Activities and Bioactive Compounds of Different Extracts Related to Syrian Traditional Products of Damask Rose (Rosa damascena)

Cited by 17 publications

References 0 publications

Phytochemical, Physiochemical, Macroscopic, and Microscopic Analysis of Rosa damascena Flower Petals and Buds

Phytochemical, Physiochemical, Macroscopic, and Microscopic Analysis of Rosa damascena Flower Petals and Buds

Pain Relieving Properties of Ginger (Z. officinale) and Echinacea (E. angustifolia) Extracts Supplementation among Female Patients with Osteoarthritis. A Randomized Study

Pharmaceutical Potential Evaluation of Damask Rose By-Products from Volatile Oil Extraction

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