Evaluation of antioxidant activity and heavy metals content in licorice (Glycyrrhiza glabra L.) growing wild in Armenia

Petrosyan, H.R.; Nigaryan, A.A.; Hovhannisyan, H.A.; Soloyan, A.M.; Vardapetyan, V.V.; Martiryan, A.I.

doi:10.1016/j.heliyon.2023.e22442

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Various studies suggest that the synthesis of secondary metabolites, essential for the therapeutic properties of these plants, is negatively impacted under such conditions ( Figure 3 ). Alkaloids, flavonoids, and phenolics, which fall under the category of secondary metabolites, may experience reduced synthesis [ 4 , 67 , 116 ]. Furthermore, heavy metal stress is linked to decreased concentrations of specific bioactive compounds.…”

Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

“…Common manifestations of heavy metal toxicity include the production of reactive oxygen species (ROS) and reactive nitrogen species (NO), as well as the disruption of enzyme cofactors and transcription factors [ 120 ]. This can also result in the inhibition of antioxidative enzymes, imbalances in cellular redox levels, disruptions in ionic transport, DNA damage, and protein oxidation [ 86 , 116 ]. The stress from heavy metals causes a decrease in molecular oxygen and the production of harmful intermediate products such as superoxide radicals (O 2 •− ), hydroxyl radicals (OH •− ), and hydrogen peroxide (H 2 O 2 ).…”

Section: Mechanisms Of Heavy Metal-induced Changes In Antioxidant Act...mentioning

confidence: 99%

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Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing on its impact on antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between heavy metals and the physiological and biochemical responses of medicinal plants, highlighting how metal stress disrupts biosynthetic pathways, altering concentrations of secondary metabolites. This disruption may compromise the overall quality and efficacy of medicinal plants, requiring a holistic understanding of its cumulative impacts. Furthermore, the study discusses the potential of targeted genetic editing to enhance plant resilience against heavy metal stress by manipulating genes associated with antioxidant defenses. This approach represents a promising frontier in safeguarding medicinal plants in metal-contaminated environments. Additionally, the research investigates the role of phytohormone signaling in plant adaptive mechanisms to heavy metal stress, revealing its influence on biochemical and physiological responses, thereby adding complexity to plant adaptation. The study underscores the importance of innovative technologies and global cooperation in protecting medicinal plants’ therapeutic potential and highlights the need for mitigation strategies to address heavy metal contamination effectively.

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Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

Section: Mechanisms Of Heavy Metal-induced Changes In Antioxidant Act...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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Metal oxides on the frontlines: Antimicrobial activity in plant-derived biometallic nanoparticles

Krishnan,

Sathishkumar,

Devi

et al. 2024

Nanotechnology Reviews

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Phytochemical, Antioxidant, Antimicrobial and Safety Profile of Glycyrrhiza glabra L. Extract Obtained from Romania

Semenescu,

Avram,

Similie

et al. 2024

Plants

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Glycyrrhiza glabra L., also known as licorice, belongs to the Fabaceae family and is one of the most commercially valuable plants worldwide, being used in the pharmaceutical, cosmetic, and food industries, both for its therapeutic benefits as well as for the sweetening properties of the extract. This study evaluates the phytochemical composition, the biological activities, and the safety profile of a methanolic extract of licorice root (LRE) obtained from Romania. Ten phytocompounds were quantified by the HPLC-DAD-ESI+, the most abundant being the triterpene glycyrrhizin (13.927 mg/g dry extract.), followed by these flavonoids: liquiritin, liquiritigenin-apiosyl-glucoside, and apigenin-rutinoside liquiritigenin. The total phenolic content of the LRE was found to be 169.83 mg gallic acid/g dry extract. (GAE/g d.e.), and the extract showed a maximum of 79.29% antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Good antimicrobial activity of the LRE was observed for Gram-negative bacteria, especially for S. pneumoniae and S. pyogenes. The mineral content of the LRE was indicative of the lack of toxicity; heavy metals such as lead, cadmium, arsenic, nickel, and cobalt were below the detection limit. The safety profile of the licorice extract was assessed using the in vivo hen egg test-chorioallantoic membrane (HET-CAM protocol), indicating no irritability, good tolerability, and biocompatibility. The phytochemical and biological characterization of the Romanian licorice root extract reveals a good source of glycyrrhizin and polyphenols with antioxidant and antimicrobial potential, along with a safety profile that may be useful for future therapeutic applications.

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Evaluation of antioxidant activity and heavy metals content in licorice (Glycyrrhiza glabra L.) growing wild in Armenia

Cited by 3 publications

References 33 publications

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Metal oxides on the frontlines: Antimicrobial activity in plant-derived biometallic nanoparticles

Phytochemical, Antioxidant, Antimicrobial and Safety Profile of Glycyrrhiza glabra L. Extract Obtained from Romania

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