Evaluation Of Atherosclerosis Severity Based On Carotid Artery Intima-Media Thickness Changes: A New Diagnostic Criterion

Rafati, Mehravar; Rahimzadeh, Mehrdad Rafati; Moladoust, Hassan

doi:10.1016/j.ultrasmedbio.2019.07.412

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…The atherosclerotic process has a long asymptomatic phase and in this subclinical phase, atherosclerosis can be detected using non-invasive methods like cIMT and EATT measurements with echocardiography 18,19 . Increased cIMT is indicative of early hemodynamic changes or early arterial damage with no clinical signs.…”

Section: Discussionmentioning

confidence: 99%

“…Increased cIMT is indicative of early hemodynamic changes or early arterial damage with no clinical signs. It is associated with coronary risk factors and increased risk of cardiovascular events 18 . It has been determined that epicardial adipose tissue contains a higher rate of inflammatory mediators in patients with coronary heart disease compared to healthy individuals 19 .…”

Section: Discussionmentioning

confidence: 99%

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Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Karpuz

Tezol

Türkegün

et al. 2022

Cukurova Medical Journal

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Purpose: We aimed to evaluate carotid intima-media thickness (cIMT) and epicardial adipose tissue thickness (EATT) concurrently as early atherosclerotic markers in pediatric patients with Celiac disease. Materials and Methods: Patients with Celiac disease (n=54) and healthy peers (n=54) aged 5-18 years were enrolled in this cross-sectional study. Patients who followed gluten free diet at least the past 12 months were included. Anthropometric and biochemical measurements were performed. cIMT and EATT were measured by echocardiography and compared between the patient and control groups. Results: Body mass index (17.4±3.0 vs. 18.4±3.1 kg/m2), blood pressure (systolic: 100 (85-120) vs. 100 (80-100) mmHg; diastolic: 60 (40-90) vs. 70 (40-90) mmHg), and lipid profile (total cholesterol: 144.6±30.2 vs. 150.8±22.6 mg/dL; triglycerides: 71.5 (27-178) vs. 92.5 (34-203) mg/dL) were not different between the patient and control groups, while there were significant differences in cIMT and EATT. The patient group had higher cIMT (0.50±0.07 vs. 0.45±0.04 mm) and EATT (5.68±0.90 vs. 4.22±0.76 mm) than the control group. The risk of vitamin D insufficiency was 2.68 times higher in the patient group (95% CI=1.19-6.03). Conclusions: Children with Celiac disease had higher cIMT and EATT than healthy peers. cIMT and/or EATT measurements by echocardiography may present as a reliable and easy method to investigate subclinical atherosclerosis in children with Celiac disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Karpuz

Tezol

Türkegün

et al. 2022

Cukurova Medical Journal

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“…4 It has been considered in studies 5 that diabetes mellitus is an independent risk factor for cardiovascular and cerebrovascular diseases, and dyslipidemia is the direct cause of atherosclerosis. 6 Carotid intima-media thickness (IMT) is associated with local lipid accumulation and is a strong predictor of subclinical atherosclerosis. 7 IMT values are associated with hypercholesterolemia regardless of genetic etiology.…”

Section: Introductionmentioning

confidence: 99%

Correlation study on the relationship between dyslipidemia and carotid intima-media thickness in patients with diabetes mellitus

Guo

Li²,

Bian³

et al. 2023

Pak J Med Sci

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Objective: To investigate the correlation between dyslipidemia and carotid intima-media thickness (IMT) in patients with diabetes mellitus. Methods: A descriptive research design was adopted in this study. One hundred and twenty patients with Type-2 diabetes mellitus who were admitted to the physical examination center of The Fourth Hospital of Hebei Medical University from June 2020 to June 2021 for physical examination were recruited to the experimental group. The 120 patients were divided into three groups according to carotid IMT: normal group, thickened group, and plaque group. Forty healthy people who underwent a physical examination during the same period were recruited as the control group. The differences in IMT in various parts of the experimental group and the control group and the differences in blood lipid indexes were compared and analyzed. In addition, the correlation between mean IMT of bilateral common carotid arteries and blood lipid levels in normal, thickened and plaque groups was compared and analyzed. Results: The intima-media thicknesses of the internal carotid artery and bilateral common carotid arteries of the patients in the experimental group were significantly thicker than those in the healthy control group, the levels of TC, TG and LDL were higher than those in the control group, while the level of HDL was lower than that in the control group, with a statistically significant difference (p=0.00). The levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), TG, TC and LDL were positively correlated with the mean IMT of bilateral common carotid arteries (p<0.05), while the level of HDL was negatively correlated with the mean IMT of bilateral common carotid arteries (p<0.05). Conclusion: Dyslipidemia and glucose metabolism in patients with Type-2 diabetes mellitus have a close bearing on carotid IMT. Clinically, patients with Type-2 diabetes mellitus can be judged by monitoring carotid IMT for dyslipidemia, atherosclerosis and other related complications. doi: https://doi.org/10.12669/pjms.39.3.6866 How to cite this: Guo HJ, Li CC, Bian XY, Hao Q. Correlation study on the relationship between dyslipidemia and arotid intima-media thickness in patients with diabetes mellitus. Pak J Med Sci. 2023;39(3):875-879. doi: https://doi.org/10.12669/pjms.39.3.6866 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Atherosclerosis is the earliest occurrence of CVD and is characterized by plaque and increased intima-media thickness (IMT) in the innermost layer of carotid arteries ( Handa et al, 1990 ; Palve et al, 2014 ; Libby et al, 2019 ; Lubrano and Balzan, 2021 ). Carotid plaque and high IMT increase the risk of myocardial infarction ( Lorenz et al, 2007 ; Naqvi and Lee, 2014 ; Rafati et al, 2019 ). Myocardial infarction decreases the blood flow through the coronary artery, severely restricting the metabolism of cardiomyocytes and compromising myocardial function ( Zhou et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Associations between electrocardiogram and carotid ultrasound parameters: a healthy chinese group study

Shi

Bi²,

Luo³

et al. 2022

Front. Physiol.

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Background: Electrocardiogram (ECG) and carotid ultrasound (CUS) are important tools for the diagnosis and prediction of cardiovascular disease (CVD). This study aimed to investigate the associations between ECG and CUS parameters and explore the feasibility of assessing carotid health with ECG.Methods: This cross-sectional cohort study enrolled 319 healthy Chinese subjects. Standard 12-lead ECG parameters (including the ST-segment amplitude [STA]), CUS parameters (intima-media thickness [IMT] and blood flow resistance index [RI]), and CVD risk factors (including sex, age, and systolic blood pressure [SBP]) were collected for analysis. Participants were divided into the high-level RI group (average RI ≥ 0.76, n = 171) and the normal RI group (average RI < 0.76, n = 148). Linear and stepwise multivariable regression models were performed to explore the associations between ECG and CUS parameters.Results: Statistically significant differences in sex, age, SBP, STA and other ECG parameters were observed in the normal and the high-level RI group. The STA in lead V3 yielded stronger significant correlations (r = 0.27–0.42, p < 0.001) with RI than STA in other leads, while ECG parameters yielded weak correlations with IMT (|r| ≤ 0.20, p < 0.05). STA in lead V2 or V3, sex, age, and SBP had independent contributions (p < 0.01) to predicting RI in the stepwise multivariable models, although the models for IMT had only CVD risk factors (age, body mass index, and triglyceride) as independent variables. The prediction model for RI in the left proximal common carotid artery (CCA) had higher adjusted R2 (adjusted R2 = 0.31) than the model for RI in the left middle CCA (adjusted R2 = 0.29) and the model for RI in the right proximal CCA (adjusted R2 = 0.20).Conclusion: In a cohort of healthy Chinese individuals, the STA was associated with the RI of CCA, which indicated that ECG could be utilized to assess carotid health. The utilization of ECG might contribute to a rapid screening of carotid health with convenient operations.

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Evaluation Of Atherosclerosis Severity Based On Carotid Artery Intima-Media Thickness Changes: A New Diagnostic Criterion

Cited by 6 publications

References 43 publications

Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Correlation study on the relationship between dyslipidemia and carotid intima-media thickness in patients with diabetes mellitus

Associations between electrocardiogram and carotid ultrasound parameters: a healthy chinese group study

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