Evaluation of behavioral and pharmacological effects of Hedyosmum brasiliense and isolated sesquiterpene lactones in rodents

Abstract

The results suggest that EEHb presents psychopharmacological activities, including anxiolytic, antidepressant, and hypnotic effects.

Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease

“…When rodents are forced to swim in a confined space, after an initial period of struggling, they would become immobile, resembling a state of despair and mental depression. This inescapable stressful situation can be evaluated by assessing different behavioral strategies (Tolardo et al, 2010). In the present study, after being treated with the methanolic extract of Hibiscus asper leaves at 50 and 100 mg/kg for 7 days, the swimming time was significantly and dose-dependently prolonged compared to the control group.…”

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

“…The number of ambulation (with at least three paws) and rearing (standing upright on hind paws), and the frequencies of grooming (including face cleaning, paw licking, fur licking, head scraping, and rubbing) were counted manually for 5 min as described in recent studies (Galdino et al, 2009;Tolardo et al, 2010). The apparatus was cleaned with 10% ethanol and dried thoroughly between tests.…”

Phytochemical analysis of the hot tea infusion of Hedyosmum brasiliense

“…Likewise compounds 5 and 6 were found to be the sesquiterpene lactones podoandin and onoseriolide respectively based on their MS and NMR data comparing to those reported in the literature (Kubo et al, 1992) (Trentin et al, 1999). Recently, a series of pharmacological assays have shown that the sesquiterpene lactone podoandin has antidepressant activities in mice (Goncalves et al, 2012;Tolardo et al, 2010).…”

“…It is employed in folk medicine irrespective of its androecious or gynoecious parts, in the form of tea or brewed in white wine as a sedative, anti-inflammatory, diuretic, aphrodisiac and also for the treatment of migraines and diseases of the ovary as well as a substitute for green tea (Di Stasi et al, 1988;Reitz, 1965). Reported pharmacological or biological information indicate that the ethanol extract, the essential oil and sesquiterpene lactones from H. brasiliense possess antinociceptive (Trentin et al, 1999), antimicrobial (Kirchner et al, 2010) and neurochemical properties (Goncalves et al, 2012;Tolardo et al, 2010). Recently, some sesquiterpene lactones and phenolic compounds from fractions of the ethanol extract have been isolated (Amoah et al, 2013).…”