Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

Lopes, Ana Cristina Távora de Albuquerque; Téo, Mirela Anne Quartaroli; Corrêa, Mônica Grazieli; Ishikiriama, Bella Luna Colombini; Campos, Mirella Lindoso Gomes

doi:10.1590/1807-2577.27815

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Our results allow us to state that occlusal trauma causes alterations in the periodontal tissues. Our hypothesis was confirmed by showing that occlusal trauma stimulates disorganization of the periodontal ligament tissue, increasing the space and consequently stimulating a process of bone resorption, corroborating to previous studies (Kaku et al, 2005;Yoshinaga et al, 2007;Walker et al, 2008;Fujii et al, 2014;Nakatsu et al, 2014;Takaya et al, 2015;Lopes et al, 2016;Tsutsumi et al, 2017).…”

Section: Discussionsupporting

confidence: 92%

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Avaliação da mecanobiologia do ligamento periodontal em ratos com trauma oclusal

Carvalho¹

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Piracicaba DEDICATÓRIADedico este trabalho aos meus pais Basílio Leite de Carvalho e Mirna Paiva de Carvalho, meu pai por ter empenhado todo o esforço em estudar e consequentemente por permitir meu estudo e minha mãe pela forma de me passar carinho e conhecimento, maneiras as quais procuro aplicar na vida profissional e pessoal.À minha Yasmin Comoti Vita Bantim pelo cuidado, afeto, compromisso e pelo amor. Aos meus filhosMiguel Carvalho e Fernanda Carvalho pela compreensão, amor, carinho e aprendizado na tarefa de educá-los. Aos meus irmãos Gustavo Paiva de Carvalho e Guilherme Paiva de Carvalho, pelos momentos de aprendizado de vida que colhi desde nossa infância e que ainda se fazem marcantes em nossas trocas de experiências. À minha avó Zebina Paiva dos Santos (materna) in memorian, minhas tias Maria Francisca Paiva dos Santos in memorian, e Mary Paiva dos Santos por ensinar a ouvir, observar e buscar fazer o correto, respeitando o próximo.

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Section: Discussionsupporting

confidence: 92%

“…Osteoclasts disappeared and there were few dilated blood vessels at day 10 (Yoshinaga et al, 2007). In this sense, intragroup analyses demonstrated bone loss at 14, 21 and 28 days (Lopes et al, 2016).…”

Section: Discussionmentioning

confidence: 79%

Avaliação da mecanobiologia do ligamento periodontal em ratos com trauma oclusal

Carvalho¹

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“…To prevent and manage AB destruction in patients with diabetes, dentists may need to better understand the process by which AB destruction is aggravated in diabetic HG. In this regard, the fact that occlusal overload causes AB resorption and that AB resorption is augmented in DM with occlusal trauma or orthodontic force under clinical conditions is noteworthy. This indicates that exertion of excessive MF on teeth may be a crucial causative factor in triggering or augmenting AB resorption in DM.…”

Section: Introductionmentioning

confidence: 99%

Synergistic alveolar bone resorption by diabetic advanced glycation end products and mechanical forces

Moon

Lee

Kim

et al. 2019

Journal of Periodontology

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Background The association between diabetes mellitus (DM) and bone diseases is acknowledged. However, the mechanistic pathways leading to the alveolar bone (AB) destruction remain unclear. This study aims to elucidate the mechanical forces (MF)‐induced AB destruction in DM and its underlying mechanism. Methods In vivo periodontal tissue responses to MF were evaluated in rats with diabetes. In vitro human periodontal ligament (PDL) cells were either treated with advanced glycation end products (AGEs) alone or with AGEs and MF. Results In vivo, the transcription of VEGF‐A, colony stimulating factor‐1 (CSF‐1), and Ager was upregulated in diabetes, whereas changes in DDOST and Glo1 mRNAs were negligible. DM induced VEGF‐A protein in the vascular cells of the PDL and subsequent angiogenesis, but DM itself did not induce osteoclastogenesis. MF‐induced AB resorption was augmented in DM, and such augmentation was morphologically substantiated by the occasional undermining resorption as well as the frontal resorption of the AB by osteoclasts. The mRNA levels of CSF‐1 and vascular endothelial growth factor (VEGF) during MF application were highly elevated in diabetes, compared with those of the normal counterparts. In vitro, AGEs treatment elevated Glut‐1 and CSF‐1 mRNA levels via the p38 and JNK pathways, whereas OGT and VEGF levels remained unchanged. Compressive MF especially caused upregulation of VEGF, CSF‐1, and Glut‐1 levels, and such upregulation was further enhanced by AGEs treatment. Conclusions Overloaded MF and AGEs metabolites may synergistically aggravate AB destruction by upregulating CSF‐1 and VEGF. Therefore, regulating the compressive overloading of teeth, as well as the levels of diabetic AGEs, may prove to be an effective therapeutic modality for managing DM‐induced AB destruction.

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Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

Cited by 2 publications

References 24 publications

Avaliação da mecanobiologia do ligamento periodontal em ratos com trauma oclusal

Avaliação da mecanobiologia do ligamento periodontal em ratos com trauma oclusal

Synergistic alveolar bone resorption by diabetic advanced glycation end products and mechanical forces

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