Evaluation of bone response to various anorganic bovine bone xenografts: an experimental calvaria defect study

Tovar, Nick; Jimbo, Ryo; Gangolli, Riddhi; Pérez‐Álvarez, Leyre; Manne, Lakshmipradha; Yoo, Doo-Yeol; Lorenzoni, Fábio César; Witek, Lukasz; Coelho, Paulo G.

doi:10.1016/j.ijom.2013.07.005

Cited by 52 publications

(50 citation statements)

References 35 publications

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“…On the other hand, the absence of a framework in GIII limited the aforementioned events and resulted in the formation of connective tissue with reduced thickness in relation to the bone edges, mainly in the central region of the defect, at 45 days. Consequently, in this group, the new bone formation was restricted to the borders, throughout the study Miguel et al, 2006Miguel et al, , 2013Tovar et al, 2014;Costa et al, 2016).…”

Section: Discussionmentioning

confidence: 92%

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

et al. 2021

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The aim of this study was to analyze the biological behavior and osteogenic potential of magnesium (Mg) substituted hydroxyapatite (HA) microspheres, implanted in a critical bone defect, considering that this ion is of great clinical interest, since it is closely associated with homeostasis and bone mineralization. For the purpose of this study, 30 rats were used to compose three experimental groups: GI -bone defect filled with HA microspheres; GII -bone defect filled with HA microspheres replaced with Mg; GIII -empty bone defect; evaluated at biological points of 15 and 45 days. The histological results, at 15 days, showed, in all the groups, a discrete chronic inflammatory infiltrate; biomaterials intact and surrounded by connective tissue; and bone neoformation restricted to the borders. At 45 days, in the GI and GII groups, an inflammatory response of discrete granulomatous chronic type was observed, and in the GIII there was a scarce presence of mononuclear inflammatory cells; in GI and GII, the microspheres were seen to be either intact or fragmented, surrounded by fibrous connective tissue rich in blood vessels; and discrete bone neoformation near the edges and surrounding some microspheres. In GIII, the mineralization was limited to the borders and the remaining area was filled by fibrous connective tissue. It was concluded that the biomaterials were biocompatible and osteoconductive, and the percentage of Mg used as replacement ion in the HA did not favor a greater bone neoformation in relation to the HA without the metal. Comportamento biológico de hidroxiapatita substituída com magnésio durante o reparo ósseoResumo O objetivo deste estudo foi analisar o comportamento biológico de microesferas de hidroxiapatita (HA) substituída com magnésio (Mg) durante o reparo de defeito ósseo crítico, tendo em vista que este íon é de grande interesse clínico, pois está intimamente associado à homeostasia e à mineralização óssea. Para tanto, utilizou-se 30 ratos para compor três grupos experimentais: GI -defeito ósseo preenchido com microesferas de HA; GII -defeito ósseo preenchido com microesferas de HA substituída com Mg; GIII (controle) -defeito ósseo vazio; avaliados nos pontos biológicos de 15 e 45 dias. Os resultados histológicos evidenciaram, aos 15 dias, discreto infiltrado inflamatório crônico e neoformação óssea restrita às bordas, em todos os grupos. Nos grupos GI e GII, os biomateriais mantiveram-se íntegros e circundados por tecido conjuntivo frouxo. Aos 45 dias, notou-se resposta inflamatória do tipo crônica granulomatosa discreta nos grupos GI e GII, e no GIII presença escassa de células inflamatórias mononucleares. As microesferas implantadas no GI e GII mantiveram-se, em sua maioria, íntegras e envolvidas por tecido conjuntivo fibroso. Notou-se discreta neoformação óssea próxima às bordas e circunjacente a algumas microesferas. No GIII, a mineralização limitou-se às bordas e a área remanescente foi preenchida por tecido conjuntivo fibroso. Conclui-se que os biomateriais foram biocompatíveis, bioativos...

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Section: Discussionmentioning

confidence: 92%

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

et al. 2021

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“…However, the donor‐site morbidities and insufficient quantities limit the application of autograft for bone repair. Although other alternatives such as allograft and xenograft also provide mechanical stability, they do have relative limitations . The artificial bone graft substitutes are gaining popularity for their unlimited supply and safety from transmissible infections …”

Section: Introductionmentioning

confidence: 99%

“…Although other alternatives such as allograft and xenograft also provide mechanical stability, they do have relative limitations. 5 The artificial bone graft substitutes are gaining popularity for their unlimited supply and safety from transmissible infections. 6 An injectable bone graft substitute can be delivered through minimally invasive surgery, fill the defect site completely, and harden in situ that can benefit repairs of bony defects.…”

Section: Introductionmentioning

confidence: 99%

Limitation of the antibiotic‐eluting bone graft substitute: An example of gentamycin‐impregnated calcium sulfate

Huang

Chang

et al. 2016

J Biomed Mater Res

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Patients with inadequate volume of alveolar processes or bone defects commonly require graft substitutes in oral, maxillofacial or orthopedic surgery. Ridge augmentation and reconstruction of facial bony defects with bone graft materials achieve better outcomes in functional and aesthetic rehabilitation. The injectable calcium sulfate filler is used widely in intra-operative applications. Calcium sulfate bone filler has been shown to upregulate bone formation-related mRNA genes in vitro and improve osseointegration in vivo. In addition, the bone graft substitute can be used as a drug delivery system for antibiotics to treat or prevent infections based on the clinical experiences. However, the influences of antibiotics addition on the calcium sulfate are not fully understood. In this study, calcium sulfate impregnated with gentamycin in different weight ratios was characterized. The results showed that gentamycin prolonged the hydration process and extended initial/final setting times of calcium sulfate. The addition of gentamycin slowed the conversion from calcium sulfate hemihydrate to dihydrate and changed the crystalline phase and microstructure. Higher amounts of gentamycin added resulted in faster degradation and lower mechanical strength of calcium sulfate. This study reveals that the extended setting time, decreased compressive strength, and the accelerated degradation of the gentamycin-impregnated calcium sulfate bone graft substitutes should be considered during intra-operative applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 80-87, 2018.

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“…The removal of all organic material is important to reduce the transmission of diseases, in particular bovine spongiform encephalopathy. 5 There are a number of bovine-derived xenograft products used for oral bone replacement grafting procedures, with published evidence supporting their use in animal preclinical models [6][7][8][9] and human clinical trials. 10 Bio-Oss ® is a xenograft that is widely used in clinical practice, for which there is a considerable body of published data.…”

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confidence: 99%

Attributes of Bio‐Oss^® and Moa‐Bone^® graft materials in a pilot study using the sheep maxillary sinus model

Smith

Duncan

Coates

2017

J of Periodontal Research

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Evaluation of bone response to various anorganic bovine bone xenografts: an experimental calvaria defect study

Cited by 52 publications

References 35 publications

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

Limitation of the antibiotic‐eluting bone graft substitute: An example of gentamycin‐impregnated calcium sulfate

Attributes of Bio‐Oss^® and Moa‐Bone^® graft materials in a pilot study using the sheep maxillary sinus model

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Evaluation of bone response to various anorganic bovine bone xenografts: an experimental calvaria defect study

Cited by 52 publications

References 35 publications

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

Biological behavior of magnesium-substituted hydroxyapatite during bone repair

Limitation of the antibiotic‐eluting bone graft substitute: An example of gentamycin‐impregnated calcium sulfate

Attributes of Bio‐Oss® and Moa‐Bone® graft materials in a pilot study using the sheep maxillary sinus model

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Attributes of Bio‐Oss^® and Moa‐Bone^® graft materials in a pilot study using the sheep maxillary sinus model