Evaluation of Cardiac Reserve Function in Gestational Hypertension

Abstract

Materials and Methods Hypertensive disorders complicating pregnancy(HDCP)is a pregnancy-specific disease. It often occurs after 20 weeks and the incidence was 9.4% in our country while 7%-12% [1] in the foreign reports. Hypertensive disorders in pregnancy is a great harm for maternals which can seriously damage the heart, brain, kidney and other organs of pregnant woman [2,3] and the incidence of premature children, fetal growth restriction, fetal distress are significantly higher. So it is the main cause of maternal and perinatal morbidity and mortality, ranking in the first 5 reasons of maternal death [4,5]. From the study of cardiac reserve function, we can reduce maternal mortality and improve the quality of perinatal care. General information This is a prospective study. Under the inclusion criteria, 112 pregnant women with gestational hypertension who do perinatal care in Department of Women's Health Care Division of Third Affiliated Hospital of Zhengzhou University from January 2009 to December 2012 were selected at random. They aged from 22 to 42 years whose mean age is 28.7 ± 3.8 years old and the gestational age ranged from 20 +1 to 39 weeks. On the other hand, we selected 224 normal pregnant women in the corresponding period who aged from 20 to 39 years (the mean age is 27.3 ± 3.8 years old) and the gestational age from 18 +2 to 40 weeks. All the pregnant women selected in the study had no other pregnancy complications. This study was approved by the Ethic Committee of Third Affiliated Hospital of Zhengzhou University, and informed consent was obtained from all participants. Criteria The diagnostic criteria of hypertensive disorders in pregnancy refer to the sixth edition of Obstetrics and Gynecology in 2004. Gestational hypertension refers to blood pressure elevated during pregnancy for the first time (blood pressure ≥ 140/90 mmHg, measuring 2 times interval of at least 4 hours) and the urine protein was negative, no other pregnancy-related complications (such as intrahepatic, cholestasis of pregnancy, gestational diabetes); no previous significant medical history (heart problems, hypertension or diabetes), and not taking any medication, known to affect heart function. Normal pregnant women refers to at least two blood pressure readings < 130/80 mmHg, no pregnancy-related complications, no significant medical history and not taking any medication known to affect heart function. Methods Collect the heart sound signals of the pregnant women with Cardiac Contractility Monitor (CCM, Bojing Medical Informatics Institute of Chongqing University model, patent number 01256971.2). This was the same device and specificity as used in the study by Xie et al and Shao et al. Then measure the amplitude and time of ingredients about heart sound and calculate S1/S2,D/S and HR. Statistical analysis Using SPSS 17.0 statistical software for statistical analysis. The index can be represented by x s ± , using group design. Statistical comparisons between groups were performed with a t-test, α=0.05 is the standard of the te...