Evaluation of changes in Doppler ultrasonography indices and levels of maternal serum angiogenic factors throughout pregnancy in ewes

Yılmaz, Özge; Gündüz, Mehmet; Dal, Gamze Evkuran; Uçmak, Melih; Uçmak, Zeynep Günay; Karaçam, Esra; Kaşıkçı, Güven; Kiliçarslan, Mehmet

doi:10.1016/j.theriogenology.2015.09.010

Cited by 13 publications

(12 citation statements)

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“…The appearance of the diastolic peak and the progressive development of the foetal/placental circulation are responsible for the RI drop. In our study, the presence of only one significant variation in RI and PI values could be due to shorter interval of observations as compared to those reported by Yilmaz et al (2017).…”

Section: Re Sultscontrasting

confidence: 68%

“…The PI and RI values decrease progressively throughout pregnancy as is well documented in ewes and other animal species (Di Salvo et al, 2006;Poulsen Nautrup, 1998;Scotti et al, 2008;Yilmaz et al, 2017) but only at week 7 before parturition was the decrease significant (a < 0.05). Despite this trend, the PI showed a slight increase between weeks 16 to 13 before parturition in accordance with what has been observed by Serin et al (2010) in goats.…”

Section: Re Sultssupporting

confidence: 56%

“…To our knowledge, this is the first study to detail qualitative characteristics and quantitative parameters of blood flow of umbilical artery throughout pregnancy in singleton sheep starting earlier (30 days vs. 45 days) than recently reported work (Yilmaz et al, ). Notably, during the first two‐thirds of pregnancy, the waveforms of umbilical arteries were discontinuous and diastolic flow appeared in the last three months of gestation.…”

Section: Discussionmentioning

confidence: 73%

“…In particular, in sheep, the works about feto‐placental hemodynamics parameters are related only to the certain periods of pregnancy (Acharya, Erkinaro, Mäkikallio, Lappalainen, & Rasanen, ; Galan et al, ; Irion & Clark, ; Schoennagel et al, ), with (Domínguez et al, ) or without the use of different drugs (Galan et al, ; Irion & Clark, ). Only recently Yilmaz et al () evaluated the changes in PI and RI of the foetal and uterine artery and various angiogenic factors in the maternal serum throughout pregnancy in ewes from 45 to 135 days of gestation.…”

Section: Introductionmentioning

confidence: 99%

“…1990; Schoennagel et al, 2014), with (Domínguez et al, 2013) or without the use of different drugs (Galan et al, 1999;Irion & Clark, 1990). Only recently Yilmaz et al (2017) evaluated the changes in PI and RI of the foetal and uterine artery and various angiogenic factors in the maternal serum throughout pregnancy in ewes from 45 to 135 days of gestation.…”

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confidence: 99%

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Doppler evaluation of umbilical artery during normal gestation in sheep

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Throughout gestation, changes in foetal umbilical cord Doppler parameters in ewes were detected. Doppler ultrasonography of the umbilical artery was performed weekly starting at 18 weeks before parturition until birth. In the foetal umbilical artery (UA), systolic peak velocity (SPV), end diastolic velocity (EDV), increased (p for within-subjects effect <0.001) while pulsatility index (PI) resistance index (RI) decreased (p for within-subjects effect <0.001) with the progress of pregnancy. A linear trend was found on all patterns (p < 0.001). In particular, the EDV values increased significantly (p < 0.05) with respect to previous weeks, at weeks 16, 11, 10, 7, and 1 before parturition. The SPV values increased significantly (p < 0.05), with respect to previous observations, at weeks 11, 10, and 7 before parturition. Finally, the PI and RI decreased significantly (p < 0.05) only at week 7 before parturition. The increased velocities and reduced resistance index suggest a progressive increment in blood flow to the foetus towards the end of pregnancy. Foetal and utero-placental vascular parameters can be reliably evaluated using high-frequency ultrasound.

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Section: Re Sultscontrasting

confidence: 68%