Evaluation of changes in endolymphatic hydrops volume after medical treatments for Meniere's disease using 3D magnetic resonance imaging

Yamashita, Akinori; Kitahara, Tadashi; Sakagami, Masaharu; Ueda, Keita; Fujita, Hiroto; Inui, Hiroshi

doi:10.1016/j.anl.2023.02.002

Cited by 3 publications

(1 citation statement)

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“…An association between MD and psychological distress, including anxiety, depression, and neuroticism is frequently reported. [37][38][39] However, whether psychological distress leads to the onset of MD or whether MD can induce psychological distress remains controversial. Do MD and psychological distress mutually influence and promote each other?…”

Section: Discussionmentioning

confidence: 99%

Psychological Distress and Meniere's Disease: A Bidirectional Two‐Sample Mendelian Randomization Study

Wu,

Xia,

Luo

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThis study is aim to explore the causal relationship between anxiety, depression, neuroticism, and Meniere's disease (MD).Study DesignTwo‐sample bidirectional Mendelian randomization (MR) analyses.SettingIEU, FinnGen, CTG, and UKB databases.MethodsThe genome‐wide association studies data for anxiety, depression, neuroticism, and MD involved over 357,957 participants. MR was performed to explore relationships between anxiety, depression, neuroticism, and MD. Sensitivity analyses were performed to assess the robustness of the MR results. Reverse MR was used to exclude the possibility of reverse causality. Finally, multivariate MR was performed to explore the collinear relationships between neuroticism subclusters.ResultsMR results showed that anxiety and depression are not causes of MD, nor does MD cause anxiety and depression. Elevated neuroticism sum score is a cause of anxiety, depression, and MD, but MD does not lead to an increase in the level of neuroticism sum score. Further analysis showed that the 5 subclusters of neuroticism often feel lonely, mood often goes up and down, often feel fed‐up, feelings easily hurt, and sensitivity to environmental stress and adversity are causes of MD. Multivariate MR analysis results suggested that the 5 neuroticism subclusters have a collinear relationship.ConclusionAnxiety and depression are not causative factors of MD, and vice versa. Elevated neuroticism levels serve as a shared causative factor for anxiety, depression, and MD. Identification and effective management of neuroticism is a potential target for preventing and treating MD.

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Section: Discussionmentioning

confidence: 99%