Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Yu, Siwu; Du, Jingjing; Luo, Ting; Huang, Yuying; Jing, Chuanyong

doi:10.1016/j.jhazmat.2012.01.009

Cited by 31 publications

(9 citation statements)

References 36 publications

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“…In Vitro Digestion Model Based on Human SHIME. The human SHIME protocol described by Van et al and Yu et al 23,24 was applied with slight modifications. The nutrition solution for digestion juice preparation contained, per liter, 1.00 g of peptone, arabinogalactan, and xylan, respectively, 2.00 g of pectin, 3.00 g of soluble starch, 4.00 g of mucin, 0.50 g of cysteine, 0.40 g of glucose, and 3.00 g of yeast and was autoclaved at 121 °C for 15 min before use.…”

Section: Methodsmentioning

confidence: 99%

Factors Affecting the Bioaccessibility and Intestinal Transport of Difenoconazole, Hexaconazole, and Spirodiclofen in Human Caco-2 Cells Followingin VitroDigestion

Shi

Xiao

Feng

et al. 2017

J. Agric. Food Chem.

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This study examined how gastrointestinal conditions affect pesticide bioaccessibility and intestinal transepithelial transport of pesticides (difenoconazole, hexaconazole, and spirodiclofen) in humans. We used an in vitro model combining human gastric and intestinal digestion, followed with Caco-2 cell model for human intestinal absorption. Bioaccessibility of three tested pesticides ranged from 25.2 to 76.3% and 10.6 to 79.63% in the gastric and intestinal phases, respectively. A marked trend similar to the normal distribution was observed between bioaccessibility and pH, with highest values observed at pH 2.12 in gastric juice. No significant differences were observed with increasing digestion time; however, a significant negative correlation was observed with the solid-liquid (S/L) ratio, following a logarithmic equation. R ranged from 0.9198 to 0.9848 and 0.9526 to 0.9951 in the simulated gastric and intestinal juices, respectively, suggesting that the S/L ratio is also a major factor affecting bioaccessibility. Moreover, significant dose- and time-response effects were subsequently observed for intestinal membrane permeability of difenoconazole, but not for hexaconazole or spirodiclofen. This is the first study to demonstrate the uptake of pesticides by human intestinal cells, aiding quantification of the likely effects on human health and highlighting the importance of considering bioaccessibility in studies of dietary exposure to pesticide residues.

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Section: Methodsmentioning

confidence: 99%

Factors Affecting the Bioaccessibility and Intestinal Transport of Difenoconazole, Hexaconazole, and Spirodiclofen in Human Caco-2 Cells Followingin VitroDigestion

Shi

Xiao

Feng

et al. 2017

J. Agric. Food Chem.

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“…The standard EXAFS data process was followed as used in our previous research Yu et al, 2012). Briefly, the spectra were processed by removing the background absorbance with a linear function through the pre-edge region, normalizing the atomic absorption, and extracting the EXAFS signal from the spectra.…”

Section: Exafs Analysismentioning

confidence: 99%

Removal of arsenate with hydrous ferric oxide coprecipitation: Effect of humic acid

Jing

Duan

et al. 2014

Journal of Environmental Sciences

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a b s t r a c tInsights from the adverse effect of humic acid (HA) on arsenate removal with hydrous ferric oxide (HFO) coprecipitation can further our understanding of the fate of As(V) in water treatment process. The motivation of our study is to explore the competitive adsorption mechanisms of humic acid and As(V) on HFO on the molecular scale. Multiple complementary techniques were used including macroscopic adsorption experiments, surface enhanced Raman scattering (SERS), extended X-ray absorption fine structure (EXAFS) spectroscopy, flow-cell attenuated total reflectance Fourier transform infrared (ATR-FTIR) measurement, and charge distribution multisite complexation (CD-MUSIC) modeling. The As(V) removal efficiency was reduced from over 95% to about 10% with the increasing HA concentration to 25 times of As(V) mass concentration. The SERS analysis excluded the HA-As(V) complex formation. The EXAFS results indicate that As(V) formed bidentate binuclear surface complexes in the presence of HA as evidenced by an As-Fe distance of 3.26-3.31 Å. The in situ ATR-FTIR measurements show that As(V) replaces surface hydroxyl groups and forms innersphere complex. High concentrations of HA may physically block the surface sites and inhibit the As(V) access. The adsorption of As(V) and HA decreased the point of zero charge of HFO from 7.8 to 5.8 and 6.3, respectively. The CD-MUSIC model described the zeta potential curves and adsorption edges of As(V) and HA reasonably well.

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“…To explore the effectiveness of the T-sand cartridge in common environmental solution matrices, 6 types of liquids were used: naturally occurring As groundwater; aged tap water; and extraction solutions for TCLP [21], Cal WET [21], IVG [22], and SET [23]. These extraction tests are widely used to identify hazardous waste materials and to characterize their As leachability.…”

Section: Applicability Tests Of the T-sand Cartridgementioning

confidence: 99%

Rapid on‐site separation of As(III) and As(V) in waters using a disposable thiol‐modified sand cartridge

Che

Zhang

et al. 2014

Enviro Toxic and Chemistry

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The rapid redox transformation of arsenic (As) species in waters presents a great environmental challenge in the accurate determination of its concentration and toxicity. The motivation of the present study was therefore to develop a method for rapid on-site separation of As(V) and As(III) in various aqueous matrices. The authors synthesized a thiol-modified sand (T-sand) that selectively removed As(III) but did not adsorb As(V). The novel application of this T-sand in a disposable cartridge was able to successfully separate As(V) (37-970 µg L(-1) ) and As(III) (not detected to 488 µg L(-1) ) in 23 groundwater samples collected in areas with naturally occurring As. The As speciation results determined with T-sand separation in the field were consistent with those obtained using high-performance liquid chromatography-atomic fluorescence spectrometry. Furthermore, the T-sand cartridge was applicable in a wide variety of matrices, including groundwater, leachants of the toxicity-characteristic leaching procedure, and extracts from the California waste extraction test; sequential extraction test; and in vitro gastrointestinal extraction. This easy-to-use separation method is especially suitable for routine field monitoring of As speciation.

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Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Cited by 31 publications

References 36 publications

Factors Affecting the Bioaccessibility and Intestinal Transport of Difenoconazole, Hexaconazole, and Spirodiclofen in Human Caco-2 Cells Followingin VitroDigestion

Factors Affecting the Bioaccessibility and Intestinal Transport of Difenoconazole, Hexaconazole, and Spirodiclofen in Human Caco-2 Cells Followingin VitroDigestion

Removal of arsenate with hydrous ferric oxide coprecipitation: Effect of humic acid

Rapid on‐site separation of As(III) and As(V) in waters using a disposable thiol‐modified sand cartridge

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