Evaluation of coagulation abnormalities in acute liver failure

Agarwal, Banwari; Wright, Gavin; Gatt, Alex; Riddell, Anne; Vemala, Vishwaraj; Mallett, Susan; Chowdary, Pratima; Davenport, Andrew; Jalan, Rajiv; Burroughs, Andrew K.

doi:10.1016/j.jhep.2012.06.020

Cited by 166 publications

(139 citation statements)

References 22 publications

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“…However, PDMP assays may consist of quantifying assays, functional assays and morphologic assays. Although the ISTH report was a first step towards achieving standardization of assay methods for evaluating PDMPs, studies continue to use different assay types [24][25][26][27][28][29][30][31][32] . Strasser and coworkers showed a good correlation among three different methods of characterizing PDMPs and suggested that an analysis method other than FCM should be used concurrently to detect MPs when the PDMP size is below the limit of detection on FCM 24) .…”

Section: Discussionmentioning

confidence: 99%

Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

Ohuchi

Fujino

Kishimoto

et al. 2015

J Atheroscler Thromb

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Aim:The role of platelet-derived microparticles (PDMPs) in the crosstalk between coagulopathy and inflammation in critically ill patients remains unclear. The aim of this cohort observational study was to investigate the associations between the PDMP levels and hospital mortality or disseminated intravascular coagulopathy (DIC). Methods: This study included 119 patients who were admitted to the ICU. The PDMP levels were measured using an enzyme-linked immunosorbent assay three times a week, for a total of 372 samples. We calculated the maximum (max) PDMP value, max PDMP/platelet (PDMP/Plts) ratio (converted to the PDMP levels per 10 4 platelets) and nadir platelet count during the ICU stay. Baseline patient data and scores, including the Japanese Association for Acute Medicine (JAAM) DIC score, were collected, and potential predictors were analyzed for possible associations with hospital mortality. Results: The max PDMP/Plts ratio was significantly different comparing the survivors (n 98: median, 2.54) and non-survivors (n 21: median 17.59; p 0.001). There was a weak but statistically significant negative correlation between the max PDMP level and nadir platelet count (r 0.332, p 0.001). The max PDMP level and max PDMP/Plts ratio were higher in the DIC group (81.48 and 9.27, respectively) than in the non-DIC group (34.88 and 2.35, p 0.001 and p 0.001, respectively). The max PDMP/Plts ratio was the only variable found to be independently associated with hospital mortality according to a multivariate logistic regression analysis. Conclusions: PDMPs are involved in the development of DIC but are not related to hospital mortality. There is a good association between the PDMP/Plts ratio and hospital mortality and/or DIC in critically ill patients.

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Section: Discussionmentioning

confidence: 99%

Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

Ohuchi

Fujino

Kishimoto

et al. 2015

J Atheroscler Thromb

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show abstract

“…Therefore, one might speculate that increased factor VIII levels might be a compensatory mechanism in case of impaired hepatic production of coagulation factors. This was shown in patients with acute liver failure in a study by Argawal et al [23], and also in a large animal model where not only increased systemic factor VIII levels but also prolonged factor VIII half-life and factor VIII production in the spleen and kidney were observed in anhepatic pigs [24].…”

Section: Discussionmentioning

confidence: 70%

Coagulation Parameters in Wilson Disease

Schaefer

Weber

Gotthardt

et al. 2015

JGLD

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Background & Aims: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. Alterations of copper metabolism have been associated with changes in coagulation factors. The aim of the present study was the analysis of coagulation factors in WD patients.Methods: 100 patients attending a tertiary WD outpatient clinic were analyzed in a prospective cross sectional cohort study. Out of peripheral venous blood samples coagulation factors were assessed including: full blood count, INR, partial thromboplastin time (PTT), clotting factors II, V, VII, VIII, IX, X, XI, XII, XIII, von Willebrand factor/-antigen, fibrinogen, antithrombin III, protein S, protein C, activated protein C (APC) resistance. Subgroup analyses of the blood tests were performed for sex, initial clinical presentation, WD treatment and liver function.Results: Subgroup analysis by liver function showed decreased levels of factors II, V, VII and X. Subgroup analysis by gender or clinical course of the disease did not reveal significant coagulation changes. In patients treated with trientine significantly decreased levels of factors II, VII and antithrombin III and increased von Willebrand factor/-antigen levels were detected. Factor VIII levels were significantly reduced in patients receiving zinc.Conclusion: Although significant differences of some coagulation parameters in subgroup analysis were found, no clinically relevant alterations of the coagulation system in WD patients could be detected.

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“…Todo lo anterior condiciona el establecimiento de un nuevo equilibrio hemostático 2 . Esto explica por qué estos pacientes rara vez presentan un estado de hipocoagulabilidad clínica, como generalmente se asume, pudiendo incluso desarrollar condiciones de hipercoagulabilidad, aun en pacientes con falla hepática aguda con INR > 2 [10][11][12] . En dos de los pacientes estudiados, el estado de coagulación se calificó como hipercoagulable y en 9 de ellos, esta condición se presentó junto a hiperfibrinolisis o hipocoagulabilidad (Tabla 2).…”

Section: Discussionunclassified

Comparación preoperatoria entre pruebas de coagulación y tromboelastografía en pacientes con cirrosis hepática sometidos a trasplante hepático

Castillo

et al. 2018

Rev. méd. Chile

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Evaluation of coagulation abnormalities in acute liver failure

Cited by 166 publications

References 22 publications

Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

Coagulation Parameters in Wilson Disease

Comparación preoperatoria entre pruebas de coagulación y tromboelastografía en pacientes con cirrosis hepática sometidos a trasplante hepático

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