Evaluation of colloid milium by in vivo reflectance confocal microscopy

Colloid milium: the expanding spectrum of orange color at dermoscopy

“…To the best of our knowledge, there are no reports in literature concerning dermoscopic findings of CM, although confocal microscopy description has been reported. 1 In our patient, we consistently found on all the lesions a regular yellowish-orange background, presumably correspondent to the dermal colloid deposits, and scattered linear vessels that can be hypothesized to represent a sign of chronic sun damage in the affected areas. The orange color at dermoscopy is not specific to CM, but it was first considered as highly suggestive of cutaneous granulomatous diseases, such as sarcoidosis, lupus vulgaris, leishmaniasis, and foreign body granulomas.…”

“…Biopsy has been considered mandatory for the diagnosis of CM, which is often found at histopathology by chance. To the best of our knowledge, there are no reports in literature concerning dermoscopic findings of CM, although confocal microscopy description has been reported . In our patient, we consistently found on all the lesions a regular yellowish‐orange background, presumably correspondent to the dermal colloid deposits, and scattered linear vessels that can be hypothesized to represent a sign of chronic sun damage in the affected areas.…”

“…The degenerative process may be secondary to excessive sun exposure that can lead to elastin degradation. Hydroquinone and ochronosis are additional predisposing factors for pigmented CM …”

“…The adult variant is the most common variant and usually presents with multiple variably sized and pink to amber papules typically affecting sun exposed areas, such as cheeks, dorsal aspect of hands, neck, and earlobes. 1 Clinical diagnosis of CM could be challenging, as several differential diagnoses can be considered as alternatives, such as sarcoidosis, Favre-Racouchot disease, trichoepitheliomas, syringomas, and sebaceous hyperplasias. Biopsy has been considered mandatory for the diagnosis of CM, which is often found at histopathology by chance.…”

Dynamic skin changes of acute radiation dermatitis revealed by in vivo reflectance confocal microscopy

“…The main application of RCM is the differential diagnosis of melanocytic lesions. Nevertheless, RCM has also been used for the evaluation of several inflammatory skin conditions, such as acute contact dermatitis, 21–24 discoid lupus erythematosus, 25 psoriasis, 26 as well as for the study of other skin conditions such as mammary and extramammary Paget's disease, 27,28 lichen planus‐like keratosis, 29 sebaceous neoplasms in Muir–Torre syndrome 30 or colloid milium 31 . Its findings have been correlated with conventional histological analysis in several studies 21 .…”