Evaluation of deep eutectic solvents for the extraction of fucoxanthin from the alga Tisochrysis lutea – COSMO-RS screening and experimental validation

Xu, Dingmeng; Chow, Jane; Weber, Cameron C.; Packer, Michael A.; Baroutian, Saeid; Shahbaz, Kaveh

doi:10.1016/j.jece.2022.108370

Cited by 14 publications

(18 citation statements)

References 39 publications

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“…The choice of these conditions was based on those used previously to benchmark the extraction of fucoxanthin from algae. 45 Figure 3 presents the experimental results for the extraction of EPA and DHA using these DESs. The experimental screening results generally agreed qualitatively with predicted values using COSMO-RS in terms of the relative order of the DESs' ability to extract EPA and DHA.…”

Section: Experimental Screening Resultsmentioning

confidence: 99%

“…The extraction was performed at 25 °C and at 1000 rpm for 1 h by mixing the mussel powder and the prepared DESs at 5 w/v% of biomass loading. The choice of these conditions was based on those used previously to benchmark the extraction of fucoxanthin from algae 45 . Figure 3 presents the experimental results for the extraction of EPA and DHA using these DESs.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty two hydrophobic DESs were selected and screened in this research. The methodology for predicting the surface charge density of EPA, DHA, and all DESs, and for optimising the molecular geometry of all compounds was performed as detailed in the previous work 45 . DESs are represented in COSMO‐RS according to the mole composition of their constituents 46,47 .…”

Section: Methodsmentioning

confidence: 99%

“…The methodology for predicting the surface charge density of EPA, DHA, and all DESs, and for optimising the molecular geometry of all compounds was performed as detailed in the previous work. 45 DESs are represented in COSMO-RS according to the mole composition of their constituents. 46,47 The activity coefficients of EPA and DHA were estimated at an infinite dilution of each DES via COSMO-RS and were used for calculating the capacity of DESs.…”

Section: Cosmo-rs Screeningmentioning

confidence: 99%

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Menthol‐based deep eutectic solvents as green extractants for the isolation of omega‐3 polyunsaturated fatty acids from Perna canaliculus

Anstiss

Weber

Baroutian

et al. 2023

J of Chemical Tech & Biotech

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BACKGROUND Marine‐derived omega‐3 polyunsaturated fatty acids (PUFA) are used globally as food supplements for their anti‐inflammatory properties and to reduce the risk of obesity, cardiovascular diseases, and cancer. New Zealand green‐lipped mussels (Perna canaliculus) contain diverse valuable compounds, including omega‐3 PUFA. The most abundant omega‐3 PUFA in Perna canaliculus are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which account for many of the health benefits accredited to these mussels. This research investigates the feasibility of using deep eutectic solvents (DESs) to isolate EPA and DHA from Perna canaliculus. RESULTS Twenty‐two hydrophobic DESs were screened using COSMO‐RS software to predict their affinity for EPA and DHA. Nine top‐ranked DESs were used for experimental extraction validation. The results exposed that the extraction capacity of the menthol: lidocaine DES (1:1 M ratio) for EPA and DHA was superior (172.04 μg EPA g−1 dry weight (DW) of biomass and 602.79 μg DHA g−1 DW) amongst other DESs. This was a considerably higher extraction yield than that observed using ethanol (95.65 μg EPA g−1 DW and 311.49 μg DHA g−1 DW). The optimisation of the menthol: lidocaine ratio identified a 1:2 M ratio as the optimal composition for this DES. The highest yields of EPA (267.59 μg g−1 DW) and DHA (1014.84 μg g−1 DW) were obtained by this optimised DES ratio at optimum extraction conditions (extraction temperature 65 °C, extraction time 2.12 h, and biomass loading 5 w/v%). The EPA and DHA showed good stability in the menthol: lidocaine DES over 7 days. This DES also showed good reusability, with a comparable extraction efficiency being observed after five extraction cycles. CONCLUSION This research revealed that menthol‐based DES can be a potential green solvent for the extraction of EPA and DHA from New Zealand green‐lipped mussels and it may be applicable for extracting other bioactive compounds with similar characteristics. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

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Section: Experimental Screening Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Cosmo-rs Screeningmentioning

confidence: 99%

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Menthol‐based deep eutectic solvents as green extractants for the isolation of omega‐3 polyunsaturated fatty acids from Perna canaliculus

Anstiss

Weber

Baroutian

et al. 2023

J of Chemical Tech & Biotech

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“…Although conventional extraction process has been used to obtain Fx, the eco-trends encourage researchers to explore and optimize more respectful and competitive extraction technologies like microwave-assisted extraction (MAE) or ultrasound-assisted extraction (UAE), which allows higher yields while providing a more environmentally friendly approach. Recently, deep eutectic solvents (DESs) have been reported for the extraction of Fx from brown microalgae ( Tisochrysis lutea ) [ 12 ] and macroalgae ( Fucus vesiculosus ) [ 13 ]. DESs have desirable properties such as thermal stability, adjustable viscosity, polarity, and high solubilization strength to extract compounds like Fx and advantages such as biodegradability, low toxicity and cost, easy production, and being environmentally and ecologically friendly.…”

Section: Introductionmentioning

confidence: 99%

Emerging Technologies to Extract Fucoxanthin from Undaria pinnatifida: Microwave vs. Ultrasound Assisted Extractions

et al. 2023

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Macroalgae are an extensive resource for the obtention of bioactive compounds, mainly phenolic compounds, phlorotannins, and pigments. Fucoxanthin (Fx) is the most abundant pigment present in brown algae and has shown several useful bioactivities that can be used to fortify products in the food and cosmetic industries. Nevertheless, to date, there is still insufficient literature reporting on the extraction yield of Fx from U. pinnatifida species from green technologies. In this regard, the present study aims to optimize the extraction conditions to obtain the highest Fx yield from U. pinnatifida through emerging techniques, namely microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). These methods will be compared with the conventional methodologies of heat-assisted extraction (HAE) and Soxhlet-assisted extraction (SAE). According to our results, even though the extraction yield could be slightly higher when using MAE than UAE, the Fx concentration obtained from the alga was double when using UAE. Thus, the Fx ratio in the final extract reached values of 124.39 mg Fx/g E. However, the optimal conditions should also be considered since UAE needed 30 min to perform the extraction, whereas MAE was able to obtain 58.83 mg Fx/g E in only 3 min and 2 bar, meaning less energy expenditure and minimum cost function. To our knowledge, this study obtains the highest concentrations of Fx ever reported (58.83 mg Fx/g E for MAE and 124.39 mg Fx/g E for UAE), with low energy consumption and short times (3.00 min for MAE and 35.16 min for UAE). Any of these results could be selected for further experiments and proposed for industrial scaling-up.

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Structural characterization and physicochemical properties of different hydrophilic natural deep eutectic solvents

Carbonell-Rozas,

Canales,

Romero-González

et al. 2024

Anal Bioanal Chem

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Evaluation of deep eutectic solvents for the extraction of fucoxanthin from the alga Tisochrysis lutea – COSMO-RS screening and experimental validation

Cited by 14 publications

References 39 publications

Menthol‐based deep eutectic solvents as green extractants for the isolation of omega‐3 polyunsaturated fatty acids from Perna canaliculus

Menthol‐based deep eutectic solvents as green extractants for the isolation of omega‐3 polyunsaturated fatty acids from Perna canaliculus

Emerging Technologies to Extract Fucoxanthin from Undaria pinnatifida: Microwave vs. Ultrasound Assisted Extractions

Structural characterization and physicochemical properties of different hydrophilic natural deep eutectic solvents

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