1990
DOI: 10.1007/bf02092160
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Evaluation of different temperature-sensitive mutant phenotypes ofSalmonella enteritidis as vaccine potentials

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Cited by 8 publications
(7 citation statements)
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“…Di¡erent temperature-sensitive mutants of bacteria have been utilized as immunogens either to evoke an antibody response [19] or to achieve protection of the immunized host [8,10,11,20]. Our results showed that ts mutants of S. enteritidis protect mice against challenge with wild-type Salmonella strains of di¡erent O serotypes.…”
Section: Discussionmentioning
confidence: 74%
See 1 more Smart Citation
“…Di¡erent temperature-sensitive mutants of bacteria have been utilized as immunogens either to evoke an antibody response [19] or to achieve protection of the immunized host [8,10,11,20]. Our results showed that ts mutants of S. enteritidis protect mice against challenge with wild-type Salmonella strains of di¡erent O serotypes.…”
Section: Discussionmentioning
confidence: 74%
“…Attenuated strains of S. enteritidis bearing temperature-sensitive (ts) mutations have been previously obtained in our laboratory [8,9]. We demonstrated that the avirulent S. enteritidis E/1/3 strain can be safely administered to experimental animals in very high doses and that it confers signi¢cant protection against oral challenge with the wildtype S. enteritidis strain [9,10].…”
Section: Introductionmentioning
confidence: 91%
“…The strains used in this study were the wildtype (wt) strain S. enteritidis #5694 and three ts derivatives isolated after UV-irradiation mutagenesis [4] (Table 1). Bacteria were cultured in Trypticase Soy broth (TSB) at 28°C or 37°C, 200 cycles min-1 in a shaking water-bath.…”
Section: Bacteria and Culturesmentioning
confidence: 99%
“…Moreover, live attenuated Salmonella can be used as a carrier or in combined vaccines to express recombinant antigen from other pathogens [3]. Different phenotypes of temperature-sensitive (ts) mutants of Salmonella have been isolated, characterized and proved to be immunogenic [4,5]. In this study the distinct colonizing ability, immunogenicity and protective capacity of different ts mutants of Salmonella enteritidis after intragastric (i.g.)…”
Section: Introductionmentioning
confidence: 99%
“…Attenuated strains of S. enteritidis bearing temperature‐sensitive (ts) mutations have been previously obtained in our laboratory [8,9]. We demonstrated that the avirulent S. enteritidis E/1/3 strain can be safely administered to experimental animals in very high doses and that it confers significant protection against oral challenge with the wild‐type S. enteritidis strain [9,10].…”
Section: Introductionmentioning
confidence: 96%