Evaluation of diterpenoids from P. ornatus as potential COX-1 inhibitors

Abstract

Natural products are a rich source of drug candidates for clinical use. The Plectranthus ornatus Codd. belongs to a genus associated to the isolation of diterpenoids which are responsible for various biological activities. The three diterpenoids under study were isolated in the past from P. ornatus and are now being evaluated as potential COX-1 inhibitors. Obtained results suggest that rhinocerotinoic acid (2), but not halimane (3) and plectrornatin C (1), has a mild COX-1 inhibitory activity. Current studies are being carried out to understand if these compounds have effect as COX-2 inhibitors. This will contribute to establish their possible interest as anti-inflammatory agents.

O Uso De Plantas Medicinais Pela População De União Da Vitória – Pr: O Saber Popular Confrontado Pelo Conhecimento Científico

“…Usado para dor de estômago, apresenta atividade antimicrobiana (Santos et al, 2014), além de um possível efeito antiinflamatório (Rijo et al, 2012) Phyllanthus niruri L.…”

Anti-mycobacterial activity of labdane and halimane diterpenes obtained from Plectranthus ornatus Codd

“…(18). The compounds were obtained by a phytochemical study that was previously performed in the described plant, using bioguided studies (18)(19)(20)(21). The structural elucidation of the bioactive metabolites was based on physicochemical data (melting point, specific rotation), spectroscopic data (UV, IR, 1D-and 2D-1 H and 13 C NMR), mass spectra, elemental analysis, and comparison with bibliographic data.…”

“…(18). Os compostos foram obtidos por um estudo fitoquímico que foi previamente realizado nesta planta, utilizando estudos bioguiados (18)(19)(20)(21). A elucidação estrutural dos metabolitos bioativos baseou-se em dados físicoquímicos (ponto de fusão, rotação específica), principalmente espectroscópicos UV, IR, 1D e espectros 2D-1 H e 13 C-RMN, espectros de massa, análise elementar e comparação com dados bibliográficos.…”

Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones

“…The Plectranthus genus has a vast variety of species scattered throughout tropical Africa, Asia, and Australia, and is known for its broad spectrum of activities [4,5]. Several species have already been screened for the presence of cytotoxic compounds with notable activities [3,6,7], such as secondary metabolites of diterpenes belonging to the abietane class [8][9][10]. Royleanones are bioactive compounds with a tricyclic skeleton characteristic of the abietane class and can possess phenolic and quinonic moieties [11].…”