Evaluation of dynamic effects of therapy-induced changes in microcirculation after percutaneous treatment of vascular malformations using contrast-enhanced ultrasound (CEUS) and time intensity curve (TIC) analyses

Wiesinger, Isabel; Jung, Woo Kyung; Zausig, N.; Wohlgemuth, Walter A.; Pregler, Benedikt; Wiggermann, P; Stroszczynski, Christian; Jung, Ernst Michael

doi:10.3233/ch-189118

Cited by 24 publications

(11 citation statements)

References 22 publications

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“…In the solid components of thyroid nodules, microcalcifications may correspond to the psammomatous calcifications associated with PTCs and are therefore considered a highly suspicious malignancy risk 71 , 72 . CEUS can clearly detect microvessel blood flow in tumors, and it can accurately evaluate the sequence and intensity of tumor perfusion and vascularity 73 , 74 . The CEUS patterns of PTCs are not only relative to the size of PTC but also to the possibility of cervical lymph node metastasis after thyroidectomy.…”

Section: Discussionmentioning

confidence: 99%

Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics

Rong

Feng

et al. 2021

Int. J. Med. Sci.

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The incidence of papillary thyroid carcinomas (PTCs) has increased rapidly during the past several decades. Until now, the mechanisms underlying the tumorigenesis of PTCs have remained largely unknown. Next-generation-sequencing (NGS) provides new ways to investigate the molecular pathogenesis of PTCs. To characterize the somatic alterations associated with PTCs, we performed whole-exome sequencing (WES) of PTCs from 23 Chinese patients. This study revealed somatic mutations in genes with relevant functions for tumorigenesis, such as BRAF, BCR, CREB3L2, DNMT1, IRS2, MSH6, and TP53. We also identified novel somatic gene alterations which may be potentially involved in PTC progression. Gene set enrichment analysis revealed that the cellular response to hormone stimulus, epigenetic modifications, such as protein/histone methylation and protein alkylation, as well as MAPK, PI3K-AKT, and FoxO/mTOR signaling pathways, were significantly altered in the PTCs studied here. Moreover, Protein-Protein Interaction (PPI) network analysis of our mutated gene selection highlighted EP300, KRAS, PTEN, and TP53 as major core genes. The correlation between gene mutations and clinicopathologic features of the PTCs defined by conventional ultrasonography (US) and contrast-enhanced ultrasonography (CEUS) were assessed. These analyses established significant associations between subgroups of mutations and respectively taller-than-wide, calcified, and peak time iso- or hypo-enhanced and metastatic PTCs. In conclusion, our study supplements the genomic landscape of PTCs and identifies new actionable target candidates and clinicopathology-associated mutations. Extension of this study to larger cohorts will help define comprehensive genomic aberrations in PTCs and validate target candidates. These new targets may open methods of individualized treatments adapted to the clinicopathologic specifics of the patients.

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Section: Discussionmentioning

confidence: 99%

Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics

Rong

Feng

et al. 2021

Int. J. Med. Sci.

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“…The addition of microbubble contrast may enhance visualization of small arteriovenous shunts and low-flow vessels compared with US with Doppler [16]. CEUS also has potential for quantifying perfusion in vascular malformations, which could be helpful in assessing treatment response [17].…”

Section: Discussion Of Procedures By Variantmentioning

confidence: 99%

ACR Appropriateness Criteria® Clinically Suspected Vascular Malformation of the Extremities

Obara

McCool

Kalva

et al. 2019

Journal of the American College of Radiology

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“…They may show low-level internal floating echoes (►Fig. 18) or a fluid-fluid level representing chyle, blood, or pus. On Doppler study, no internal vascularity is noted (►Fig.…”

Section: Lymphatic Malformationsmentioning

confidence: 99%

“…Various parameters like time to peak and area under the curve can be studied in different regions of interest in the center and at the periphery of the lesion, and comparison of pretreatment and posttreatment values has a role in monitoring response to therapy. 18 …”

Section: Contrast-enhanced Ultrasoundmentioning

confidence: 99%

A Step-by-step Sonographic Approach to Vascular Anomalies in the Pediatric Population: A Pictorial Essay

Mittal

Anand

gauba

et al. 2021

Indian Journal of Radiology and Imaging

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Vascular anomalies are a common cause of soft-tissue masses in children and often referred for ultrasonographic (USG) evaluation. They are broadly classified as vascular tumors (hemangiomas, hemangioendotheliomas, and angiosarcomas) or vascular malformations (venous malformations, lymphatic malformations, and arteriovenous malformations). Findings on USG and Doppler imaging can be used to categorize vascular anomalies into high- or low-flow lesions, which forms the basis for further workup, diagnosis, and management. On careful evaluation of various sonographic features, in conjunction with clinical findings, an accurate clinicoradiological diagnosis can be made in most cases. Further imaging with magnetic resonance (MR) imaging or computed tomography (CT) helps in delineation of lesion extent, whereas MR or CT angiography is useful to map the vascular supply of high-flow lesions. We have illustrated and discussed a step-by-step approach to diagnose vascular anomalies using ultrasound and Doppler imaging.

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Evaluation of dynamic effects of therapy-induced changes in microcirculation after percutaneous treatment of vascular malformations using contrast-enhanced ultrasound (CEUS) and time intensity curve (TIC) analyses

Abstract: Analyzing the capillary microcirculation TICs offer a possibility of monitoring therapy-induced capillary changes of vascular malformations.

Cited by 24 publications

References 22 publications

Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics

Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics

ACR Appropriateness Criteria® Clinically Suspected Vascular Malformation of the Extremities

A Step-by-step Sonographic Approach to Vascular Anomalies in the Pediatric Population: A Pictorial Essay

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