Evaluation of endoscopic and histological findings in <i>Helicobacter pylori</i>‐positive Japanese young adults

Kamada, Takenobu; Sugiu, Kuniaki; Hata, Jiro; Kusunoki, Hiroaki; Hamada, Hiroshige; Kido, Soichiro; Nagashima, Y; Kawamura, Yoichi; Tanaka, Shinji; Chayama, Kazuaki; Haruma, Ken

doi:10.1111/j.1440-1746.2006.04128.x

Cited by 24 publications

(16 citation statements)

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“…Kamada et al24 studied the endoscopic and histologic findings in young patients with H. pylori infection by using biopsy specimens of gastric antrum from 112 Japanese patients under 29 years of age. They reported that in monocyte infiltration, 6 cases (5.4%) were mild, 52 cases (46.4%) were moderate, and 54 cases (48.2%) were classified as marked, and all cases showed monocyte infiltration.…”

Section: Discussionmentioning

confidence: 99%

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

et al. 2007

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PurposeThe aim of this study was to investigate the pathologic characteristics of nodular gastritis in children and young adults infected with Helicobacter pylori (H. pylori).Materials and MethodsA total of 328 patients were enrolled in this study, and the diagnosis of H. pylori infection was done with gastroduodenal endoscopy concomitant with a CLO™ test and pathologic analysis of the biopsy specimens. Diagnoses of normal, superficial gastritis, nodular gastritis, and peptic ulcer disease were made from the gastroduodenal endoscopic findings. The density of H. pylori organisms in the gastric mucosa was rated as normal, mild, moderate, or marked. The pathologic findings of nodular gastritis were based on the histopathologic findings of inflammation, immune activity, glandular atrophy and intestinal metaplasia. Each of these findings was scored as either normal (0), mild (1), moderate (2), or marked (3) according to the updated Sydney system and using visual analog scales. The gastritis score was the sum of the four histopathologic scores.ResultsIn this study, nodular gastritis (50.6%) was most common, and mild density (51.5%) H. pylori infection was also common upon microscopic examination. Intestinal metaplasia occurred in 9 patients (2.7%).ConclusionLogistic regression revealed a significant increase in the incidence of nodular gastritis with gastritis score (p = 0.008), but not an association with sex, age, or H. pylori density. Gastritis score was the only significant factor influencing the occurrence of nodular gastritis. Intestinal metaplasia, which was originally thought to be a pre-malignant lesion, occurred in 2.7% of the patients with H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

et al. 2007

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“…The difference in endoscopic surveillance and baseline atrophic gastritis of patients between their study and ours might have contributed to the difference in detection rates. In our recent study, 22 histological corpus gastritis was found with high frequency in young H. pylori-positive patients. Therefore, we recommend that eradication of H. pylori should be attempted to prevent gastric cancer in young H. pyloripositive patients.…”

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Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Kamada

Hata

Sugiu

et al. 2005

Aliment Pharmacol Ther

135

149

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SUMMARYBackground: Eradication of Helicobacter pylori is expected to prevent the development of gastric cancer. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Aim: To conduct a prospective study to determine the clinical features of patients who underwent successful eradication and were later diagnosed with gastric cancer. Methods: A total of 1787 patients (1299 males and 488 females; mean age, 58.2 years; range: 15-84) who underwent successful eradication therapy between April 1994 and March 2001 were our study subjects.

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“…Some investigators have reported that H. pylori infection is associated with gastric erosion [21,22], while others have found no such correlation [23,24]. It is widely accepted that gastric erosion occurs after successful eradication of H. pylori [25].…”

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confidence: 98%

Helicobacter pylori status and esophagogastroduodenal mucosal lesions in patients with end-stage renal failure on maintenance hemodialysis

et al. 2010

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Evaluation of endoscopic and histological findings in Helicobacter pylori‐positive Japanese young adults

Abstract: The study shows that H. pylori infection is strongly associated with chronic gastritis and peptic ulcers, and that histological corpus gastritis was found with high frequency in Japanese young adults.

Cited by 24 publications

References 24 publications

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Helicobacter pylori status and esophagogastroduodenal mucosal lesions in patients with end-stage renal failure on maintenance hemodialysis

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