Evaluation of endothelial dysfunction and its improvement after cardiac rehabilitation

Cozma, Angela; Sitar-Tăut, Adela-Viviana; Fodor, Adriana; Oltean, Monica; Minciună, Ioan-Alexandru; Breaban, Iulia; Matuz, Roxana; Răcătăianu, Nicoleta; Dogaru, Gabriela; Orășan, Olga Hilda

doi:10.12680/balneo.2018.214

Cited by 1 publication

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“…Despite the large amount of data reported to date, there are still many unknown aspects related to the mode of action and the role of various molecules secreted by the adipose tissue, the interaction between them and their implication in the pathogenesis and the diagnosis of insulin resistance and endothelial dysfunction, obesity and diabetes mellitus [25]. The previously mentioned concepts (MHO, MUO) create more difficulties in understanding adiposity-related inflammation and neuroendocrine function, variant molecules' expression being influenced by obesity phenotype.…”

Section: Introductionmentioning

confidence: 99%

Diabetes and Obesity—Cumulative or Complementary Effects On Adipokines, Inflammation, and Insulin Resistance

Sitar-Tăut

Coste

Ţărmure

et al. 2020

JCM

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Background: Diabetes and obesity are increasingly significant public health issues. The aim of this study was to evaluate the relationship between adipocytokines (leptin, ghrelin, and chemerin), inflammation (sVCAM1—soluble vascular adhesion molecule 1, sICAM1—soluble intercellular adhesion molecule 1), and insulin resistance in the presence of obesity and diabetes mellitus. Methods: 88 subjects, with a mean age of 61.96 ± 10.15 years, 75% of whom were women, were evaluated (in order to consider different associations between obesity and diabetes, subjects were categorized into four groups). Results: Overall, we found significant correlations between sICAM1-sVCAM1 rho = 0.426 and ghrelin-chemerin rho = −0.224. In the obesity + diabetes group, leptin correlated with sICAM1 rho = 0.786, and sVCAM1 negatively with glycemia/insulin rho = −0.85. Significant differences were found between the groups regarding sVCAM1 (p = 0.0134), leptin (p = 0.0265) and all insulin resistance scores, with differences influenced by the subjects’ gender. In conclusion, although there are currently many unknown aspects of the release and the role of various adipokines, in particular chemerin, its implication in early glucose metabolism dysregulation disorders seems very likely.

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Section: Introductionmentioning

confidence: 99%