Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation

Çetindağlı, İbrahim; Kara, Muammer; Tanoğlu, Alpaslan; Özalper, Veysel; Aribal, Serkan; Hancerlı, Yusuf; Ünal, Mehmet; Ozari, Onur; Hira, Serdar; Kaplan, Mustafa; Yazgan, Yusuf

doi:10.1016/j.clinre.2017.01.005

Cited by 28 publications

(27 citation statements)

References 45 publications

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“…SEPP levels were also shown to be inversely associated with MetS [19,24]. These and our findings are contradictory to other 2 studies showing higher SEPP in NAFLD patients than controls [17,18]. However, in these studies, BMI and/or WC were lower in the controls than NAFLD patients, and the NAFLD diagnosis was based on computerized tomography [17] or ultrasound [18].…”

Section: Discussioncontrasting

confidence: 99%

“…These and our findings are contradictory to other 2 studies showing higher SEPP in NAFLD patients than controls [17,18]. However, in these studies, BMI and/or WC were lower in the controls than NAFLD patients, and the NAFLD diagnosis was based on computerized tomography [17] or ultrasound [18]. In the latter study, SEPP was ▶table 1 Unadjusted and adjusted comparative data between patients with SS, borderline and definite NASH, and controls.…”

Section: Discussioncontrasting

confidence: 99%

“…In the latter study, SEPP was ▶table 1 Unadjusted and adjusted comparative data between patients with SS, borderline and definite NASH, and controls. higher in NASH than SS in a subset of patients (approximately 30 %) subjected to liver biopsy [18]. Notably, SEPP levels were measured with different ELISA kits in all studies, which may partly account for the SEPP difference between studies.…”

Section: Discussionmentioning

confidence: 96%

“…Existing data for SEPP in NAFLD are limited and conflicting. Some authors reported higher SEPP in NAFLD patients than controls [17,18], whereas others a J-shaped relation of SEPP with hepatic steatosis [19].…”

Section: Introductionmentioning

confidence: 98%

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Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Polyzos

Mavrouli

Katsinelos

et al. 2019

Exp Clin Endocrinol Diabetes

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Objective Main aim of this study was to evaluate circulating selenoprotein P (SEPP) levels in patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) compared with healthy controls. Methods Thirty-one patients with biopsy-proven NAFLD (15 with SS, 10 with borderline NASH, 6 with definite NASH) and 27 matched controls without NAFLD were enrolled. Serum SEPP levels and liver function tests plus biochemical parameters were measured with ELISA and standard methods, respectively. Homeostatic model of assessment - insulin resistance (HOMA-IR) was calculated. Results SEPP levels were statistically different between groups (p-value for trend=0.043). In pairwise comparisons, SEPP was lower in definite NASH compared with controls (p=0.029), but not SS (p=0.18) or borderline NASH (p=0.35). SEPP was not different between controls, SS and borderline NASH. The unadjusted trend between the controls, SS and NASH patients remained essentially unchanged after adjustment for age, sex, log(ALT) and waist circumference, but it marginally lost significance when log(HOMA-IR) entered into the model. SEPP levels were not different between groups of different severity of steatosis, fibrosis, hepatocellular ballooning, lobular and portal inflammation. Conclusions Lower SEPP levels were observed in patients with definite NASH compared with controls, a finding warranting larger studies.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

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Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Polyzos

Mavrouli

Katsinelos

et al. 2019

Exp Clin Endocrinol Diabetes

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“…TGFβ, PDGF and FGF), and hypoxia-induced vasomotion and vesicular remodeling. 60) Using PAH patient-derived lung tissue and pulmonary artery smooth muscle cells (PASMCs), as well as Selenop −/− mice, Kikuchi and coworkers showed that 1) plasma SeP in PAH patients was elevated likely due to SeP overexpression in PASMCs, but not in the liver; 2) PAH-PASMCs secrete and receive SeP, as an autocrine signal, to promote their own proliferation and survival by activating the AKT, extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) and HIF1α pathways, probably through ApoER2; 3) SeP is induced in mice when exposed to hypoxia (10% O 2 ) that causes the muscularization of pulmonary arteries and pulmonary hypertension, mimicking human PAH; and, 4) Selenop −/− mice were resistant to the induction of PAH-related symptoms by hypoxia compared to wild-type animals, whereas the exogenous expression of SeP in wild-type mice exacerbates the symptoms. 21) Together, these demonstrated an essential role of SeP in PAH progression, suggesting SeP as a therapeutic target for this heretofore undruggable disease.…”

Section: Pah and Sepmentioning

confidence: 99%

Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More

Tsutsumi

Saito

2020

Biological & Pharmaceutical Bulletin

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Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.

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Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Khoshbaten,

Maleki,

Hadad

et al. 2023

Health Science Reports

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IntroductionThe relationship between cardiovascular disorders and nonalcoholic fatty liver disease (NAFLD) has been extensively studied. To better pool this data and make a more definite conclusion, we performed a meta‐analysis to evaluate the association between NAFLD and the thickness of media and intima of carotid artery (CIMT) and cardiovascular disorders.MethodsWe searched PubMed, Ovid, Scopus, ProQuest, Web of Science, and the Cochrane Library, and analyzed the pooled data using R studio and the “metafor” package.ResultsThe final analysis included a total of 59 studies with 16,179 cases and 26,120 control individuals. NAFLD was shown to be associated with an increase of 0.1231 mm (20.6%) in carotid artery intima‐media thickness (CIMT) (p = 0.002, 95% confidence interval [CI]: 0.0462–0.2000) in individuals with NAFLD. The prevalence of atherosclerotic plaques in the carotid arteries and the occurrence of NAFLD are significantly correlated, according to a meta‐analysis based on 17 distinct studies (p = 0.001, 1.28–1.43, 95% CI, odds ratio = 1.356).ConclusionPatients with increased CIMT are considerably more likely to have NAFLD. Large prospective investigations are required to corroborate these findings and their prognostic significance, along with the effectiveness of the available interventions.

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Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation

Cited by 28 publications

References 45 publications

Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

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