Evaluation of Endothelial Mucin Layer Thickness After Phacoemulsification With Next Generation Ophthalmic Irrigating Solution

Abstract

In this in vitro corneal model, NGOIS, due to its lower surface tension and higher viscosity, preserved endothelial mucin layer thickness better than BSS PLUS with both the INFINITI Vision System (pulsed US) and the LEGACY surgical system (continuous US).

Simulation of flow field during irrigation/aspiration in phacoemulsification using computational fluid dynamics

“…5,8,9,12 They clearly show that a positive gauge pressure in the anterior chamber leads to a stable condition during the I/A process. In addition, the simulation results for the pressure variation can be used to evaluate the safe range of flow rates for various types of I/A systems.…”

“…They concluded that postocclusion surge decreased linearly with increasing bottle height with the Infiniti system but was relatively constant with increasing bottle height with the Millennium system. Ghate et al 5 evaluated human corneal endothelial mucin layer thickness and ultrastructure after phacoemulsification and I/A with the next-generation ophthalmic irrigating solution and fortified balanced salt solution (BSS Plus). They concluded that the nextgeneration ophthalmic irrigating solution, due to its lower surface tension and higher viscosity, preserves endothelial mucin layer thickness better than the fortified balanced salt solution.…”

“…7 The literature contains few studies of I/A in phacoemulsification within the context of fluid mechanics. 5,[7][8][9][10][11][12] In recent years, the computational fluiddynamic technique has been widely used for modeling fluid flows in complex configurations. Computational fluid dynamics is a branch of fluid mechanics that uses numerical methods and algorithms for solving the governing differential equations to analyze problems involving fluid flows.…”

“…4 Researchers have raised the question of whether this turbulence could damage the endothelial cells. 5 Different I/A methods are used to remove cortical materials during phacoemulsification. Coaxial and bimanual are the most common types of I/A handpieces.…”