Evaluation of EZH2 and ERRα in colorectal carcinoma: an immunohistochemical study

Gabal, Hoda Abou; Ahmed, Noha; Meckawy, Ghada Refaat; Yassin, Radwa; Hakim, Sarah Adel

doi:10.5114/pjp.2021.111770

Cited by 2 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent evidence have reported the critical role of ERR in various metabolic diseases and cancer [ 309 , 311 ]. In line with this, studies have also evaluated the role of ERR in regulating various molecules and processes involved in CRC [ 96 , 97 , 99 , 312 ].…”

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

“…The expression of ERR α was found to be upregulated in CRC cells and tissues [ 96 , 97 , 99 , 312 ]. In addition, ERR α overexpression was associated with shorter OS and progression-free survival (PFS) and correlated with advanced stage and higher tumor grade [ 99 ]. Additionally, the overexpression of ERR α was found to increase the proliferation and migration of CRC cells via elevating the expression of IL-8 [ 312 ].…”

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

See 2 more Smart Citations

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Manickasamy,

Jayaprakash,

Girisa

et al. 2024

Discov Onc

View full text Add to dashboard Cite

Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to GLOBOCAN 2020, CRC ranks third in incidence and second in mortality in both males and females. Despite extensive studies over the years, there is still a need to establish novel therapeutic targets to enhance the patients’ survival rate in CRC. Nuclear receptors (NRs) are ligand-activated transcription factors (TFs) that regulate numerous essential biological processes such as differentiation, development, physiology, reproduction, and cellular metabolism. Dysregulation and anomalous expression of different NRs has led to multiple alterations, such as impaired signaling cascades, mutations, and epigenetic changes, leading to various diseases, including cancer. It has been observed that differential expression of various NRs might lead to the initiation and progression of CRC, and are correlated with poor survival outcomes in CRC patients. Despite numerous studies on the mechanism and role of NRs in this cancer, it remains of significant scientific interest primarily due to the diverse functions that various NRs exhibit in regulating key hallmarks of this cancer. Thus, modulating the expression of NRs with their agonists and antagonists, based on their expression levels, holds an immense prospect in the diagnosis, prognosis, and therapeutical modalities of CRC. In this review, we primarily focus on the role and mechanism of NRs in the pathogenesis of CRC and emphasized the significance of targeting these NRs using a variety of agents, which may represent a novel and effective strategy for the prevention and treatment of this cancer. Graphical Abstract

show abstract

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Manickasamy,

Jayaprakash,

Girisa

et al. 2024

Discov Onc

View full text Add to dashboard Cite

show abstract

Evaluation of the significance of human class I homeobox A13 and STK4/MST1 expression in conventional colorectal adenoma and adenocarcinoma and correlation with clinicopathological parameters (immunohistochemical study)

Abdel-Aal

Soliman

2022

Egyptian Journal of Pathology

View full text Add to dashboard Cite

Background Colorectal carcinoma (CRC) is the third most common cancer in the world. Human class I homeobox A13 (HOXA13) was initially identified as a transcription factor and has an important role in embryonic development and malignant transformation. Mammalian STE20-like kinase 1 (STK4/MST1) encodes a serine/threonine kinase that is the mammalian homolog of the Hippo pathway and plays an important role in controlling cell growth, apoptosis, and organ size. Aim This work aimed to evaluate the role of HOXA13 and STK4/MST1 in conventional colorectal adenoma and adenocarcinoma. Materials and methods This retrospective study was carried out on 20 cases of conventional colorectal adenoma and 30 cases of conventional colorectal adenocarcinoma. HOXA13 and STK4/MST1 immunostaining was done and assessed for each case. Correlation with the clinicopathological findings and statistical analysis was studied. Results In the carcinoma cases, there was a highly significant direct statistical correlation between HOXA13 expression and tumor grade, lymph node metastasis, and TNM stage (P<0.01 for each). Inverse statistical correlation between STK4/MST1 expression and tumor grade, depth of tumor invasion (T), and TNM stage (P<0.01 for each) was found. HOXA13 and STK4/MST1 immunoexpression showed direct highly significant relation with the transition from adenoma to adenoma with dysplasia to adenocarcinoma (P<0.01). There was a highly significant inverse statistical correlation between HOXA13 and STK4/MST1 expression in the studied cases of CRC (P<0.01). According to receiver-operating characteristic curve, both markers were good in the prediction of metastatic potential in the carcinoma cases using the TNM stage as a parameter with a sensitivity of 85%. Conclusion HOXA13 was immunohistochemically overexpressed, while STK4/MST1 was downexpressed in progression from colorectal adenoma to adenoma with dysplasia to adenocarcinoma cases. HOXA13 and STK4/MST1 might have a potential role as independent prognostic factors in CRC and may have validity to predict metastatic potential of CRC.

show abstract

Evaluation of EZH2 and ERRα in colorectal carcinoma: an immunohistochemical study

Cited by 2 publications

References 41 publications

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Evaluation of the significance of human class I homeobox A13 and STK4/MST1 expression in conventional colorectal adenoma and adenocarcinoma and correlation with clinicopathological parameters (immunohistochemical study)

Contact Info

Product

Resources

About