Evaluation of Fructosamine 3-kinase and Glyoxalase 1 activity in normal and breast cancer tissues

Role of the Glyoxalase System in Breast Cancer and Gynecological Cancer-Implications for Therapeutic Intervention: a Review

“…Samples were drawn in the period from 1999 to 2000 of 20 women and Glo1 was significantly upregulated in human breast cancer cells and tissues, as shown by both spectrophotometrical assay and electrophoretic pattern compared with normal counterparts. A consistent enhanced of Glo1 expression was observed either at mRNA or protein level in human breast cancer tissues parallel with pair-matched normal tissue, providing evidence for a potential role of this enzyme in breast cancer (86)(87)(88)(89). In addition, Glo1 promoted cell proliferation, invasion and migration and suppressed cell apoptosis.…”

Exosomal MALAT1 promotes the proliferation of esophageal squamous cell carcinoma through glyoxalase 1-dependent methylglyoxal removal

“…Being widely accepted as an oncogene, GLO1 in malignant biology has attracted considerable attention [ 12 ]. Previous studies have revealed the involvement of GLO1 in gastric [ 13 ], breast [ 14 ], skin [ 15 ], and prostate cancers [ [16] , [17] , [18] ], and efforts have been made to develop GLO1-based anticancer therapies [ 19 , 20 ]. To the best of our knowledge, this study is the first to uncover the role of GLO1 in ESCC and to characterize the regulatory mechanism of MALAT1 in enhancing GLO1 expression.…”