2014
DOI: 10.4314/tjpr.v13i8.2
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Evaluation of Gentamicin-Entrapped Solid Lipid Microparticles Formulated with a Biodegradable Homolipid from <i>Capra hircus</i>

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Cited by 14 publications
(19 citation statements)
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“…This expectedly shows that the higher the gentamicin incorporated, the greater the antibacterial activity. The result of the IZD measurement as presented in table (5) is in agreement with earlier findings that the quantity of drug loaded into the lipid matrix is directly proportional to the IZD produced [24,31]. Statistically, the pharmacological effects exhibited on the microbes by different batches of the formulation vary significantly (p<0.05).…”
Section: Resultssupporting
confidence: 78%
See 1 more Smart Citation
“…This expectedly shows that the higher the gentamicin incorporated, the greater the antibacterial activity. The result of the IZD measurement as presented in table (5) is in agreement with earlier findings that the quantity of drug loaded into the lipid matrix is directly proportional to the IZD produced [24,31]. Statistically, the pharmacological effects exhibited on the microbes by different batches of the formulation vary significantly (p<0.05).…”
Section: Resultssupporting
confidence: 78%
“…It can, therefore, be inferred that the particle morphology and flow characteristics of the formed microparticles are influenced by the relative proportion of the lipid matrix content similar to earlier reported cases [17,24]. [12,31]. This is an affirmation of the stability of the formulations.…”
Section: Resultssupporting
confidence: 65%
“…This amorphous feature was observed at lower enthalpy and less crystallinity of the matrixes, which could lead to retention of the entrapped drug over time. The reduced crystallinity may indicate imperfect lattices leading to a special pocket that can accommodate a large number of drug molecules [23]. Hence, an increase in the quantity of PEG-4000 was observed to increase the crystallinity of the formulations, the order being as follows: A5 > A4 > A3 > A2 > A1.…”
Section: Thermal Analysismentioning
confidence: 97%
“…Moreover, particle size may be affected by one or more factors, including, among others, the degree of homogenization, homogenization speed, composition ratio, rate of particle size growth, and crystal habit of the particle [24]. During Ostward ripening, the particles tend to move towards one another, which leads to the formation of aggregates due to the kinetic advantage gain by larger crystals as a result of an increase in the concentration [23,24]. In this study, the particle size was found to increase with increasing PEG/mucin ratio.…”
Section: Morphology and Particle Size Of Insulin-loaded Mpsmentioning
confidence: 99%
“…Gentamicin is an antibiotics belonging to the aminoglycoside group and is used in the control of severe infections caused by Gram-positive and Gramnegative microorganisms [1]. It has rapid bactericidal activity and comparatively low levels of resistance in most community and hospital associated gram-negative pathogens and these properties made it a very useful empirical drug when rapid control of a serious infection is required [2].…”
Section: Introductionmentioning
confidence: 99%