Evaluation of grip strength in normal and obese Wistar rats submitted to swimming with overload after median nerve compression

Abstract

r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):43-47 REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r a b s t r a c t Objective: To verify the functionality through muscle grip strength in animals with obesity induced by monosodium glutamate (MSG) and in control animals, which suffered compression of the right median nerve, and treated with swimming with overload.Methods: During the first five days of life, neonatal Wistar rats received subcutaneous injections of MSG. The control group received a hypertonic saline solution. Forty-eight rats were divided into six groups: G1 (control); G2 (control + injury); G3 (control + injury + swimming); G4 (obese); G5 (obese + injury); and G6 (obese + injury + swimming). The animals in groups G2, G3, G5 and G6 were submitted to compression of the median nerve and G3 and G6 groups were treated, after injury, with swimming exercise with load for three weeks. The swimming exercise had a progressive duration, according to the week, of 20, 30 and 40 min.Muscle strength was assessed using a grip strength meter preoperatively and on the 3rd, 7th, 14th and 21st days after surgery. The results were expressed and analyzed using descriptive and inferential statistics.Results: When the grip strength was compared among assessments regardless of group, in the second assessment the animals exhibited lower grip strength. G1 and G4 groups had greater grip strength, compared to G2, G3, G4 and G6. Conclusion:The swimming exercise with overload has not been effective in promoting improvement in muscle grip strength after compression injury of the right median nerve in control and in obese-MSG rats.

Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats

“…Changes in this indicator can have both a central nature and indicate a violation of the energy metabolism processes in muscle tissue (Coradinia et al. ; Fujiwara et al. ; Martinez‐Huenchullan et al.…”

Vitamin D3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D3 deficiency diet (VDD)-induced rats model

“…Coradini et al (2015) reported weak muscle strength in nerve compression model due to hypernociception [ 14 ]. Vitamin D is directly involved in muscle function.…”

Negative neuromuscular and functional repercussion of forced swimming after axonotmesis

“…However, the swimming exercise with overload (10% of the BW) was not beneficial in promoting improvement in grip strength after median nerve crush. The swimming protocol had 3 weeks duration with 20, 30, and 40 min and it started 3 days after injury ( Coradinia et al, 2015 ). Already in an autologous nerve graft model a swimming protocol, 30 min 5 times a week without load did not present differences in both function and motor neuron number ( Andrade et al, 2020 ).…”

“…Patients’ age, site and degree of injury need to be considered ( Faroni et al, 2015 ; Panagopoulos et al, 2017 ). The sciatic nerve crush model is the most used in the experimental research on the neuromuscular regeneration and functional recovery after peripheral nerve crush injury ( Coradinia et al, 2015 ; de Moraes et al, 2018 ; Goulart et al, 2014 ; Ni et al, 2017 ; Teodori et al, 2011 ; Udina et al, 2011b ; Yang et al, 2015 ). However, many peripheral injuries in humans occur in the upper limb which makes the median nerve model clinically relevant ( Jager et al, 2014 ).…”